中文
英语
JC-1
CAS:No.3520-43-2
英文名称:JC-1
分子式:C25H27Cl4IN4
分子量:652.23
储存条件:Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year
纯度:HPLC≥95%
产品简介
| CAS | No.3520-43-2 |
| 英文名称 | JC-1 |
| 别名 | CBIC2;JC-1;1，1，3，3-tetraethyl-5，5，6，6-tetrachloroimidacarbocyanine iodide |
| 分子式 | C25H27Cl4IN4 |
| 分子量 | 652.23 |
| 溶解性 | Soluble in DMSO |
| 纯度 | HPLC≥95% |
| 外观(性状) | Solid |
| 储存条件 | Powder:-20℃，1 year;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| MDL | MFCD00188475 |
| SMILES | ClC1=C(Cl)C=C([N+](CC)=C(/C=C/C=C2N(C(C=C(Cl)C(Cl)=C3)=C3N\2CC)CC)N4CC)C4=C1.[I-] |
| 背景说明 | 是一种广泛用于检测线粒体膜电位的荧光探针。通过JC-1从红色荧光到绿色荧光的转变可以很容易地检测到细胞膜电位的下降,同时也可以将该转变作为细胞凋亡早期的一个检测指标。 |
| 生物活性 | JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells， tissues or purified mitochondria. In normal mitochondria， JC-1 aggregates in the mitochondrial matrix to form a polymer， which emits strong red fluorescence (Ex=488 nm， Em=595 nm); When the mitochondrial membrane potential is low， JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=488 nm， em= 530 nm)[1]. |
| In Vitro | The sensitivity and specificity of three fluorescent probes used for cytofluorimetric analysis of mitochondrial membrane potential (delta psi) were studied in the U937 human cell line. First， the role of plasmamembrane in influencing the binding of the probes to mitochondria has been investigated. The depolarization of plasmamembrane with high doses of extracellular KCl had no immediate effects on the loading of JC-1， DiOC6(3) and rhodamine 123 (R123). However， after a few hours of culture in the presence of KCl， significant changes were observed only in cells stained with DiOC6(3). Second， a comparative study was performed concerning the effects of agents capable of collapsing deltapsi. While adding FCCP to cell cultures resulted in consistent changes in the fluorescence emission of both JC-1 and DiOC6(3) - but not of R123 - only cells stained with JC-1 responded to valinomycin.[4] |
| 数据来源文献 |
[1]. A Perelman， et al. JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 2012 Nov 22;3:e430. [2]. Vera C. Keil， et al. Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria. Pflügers Archiv - European Journal of Physiology. 2011，462(5): 693-708. [3]. Jung-Ho LEE， et al. Real-time analysis of amyloid fibril formation of α-synuclein using a fibrillation-state-specific fluorescent probe of JC-1. Biochem. J. 2009， 418:311-323. [4]. Salvioli S， et al. JC-1， but not DiOC6(3) or rhodamine 123， is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 1997 Jul 7;411(1):77-82. |
| 规格 | 1mg |
| 单位 | 瓶 |
是一种广泛用于检测线粒体膜电位△Ψ m 的理想荧光探针。在线粒体膜电位较高时,JC-1 聚集在线粒体的基质中,形成聚合物,可以产生红色荧光;在线粒体膜电位较低时,JC-1 不能聚集在线粒体的基质中,此时JC-1 为单体,可以产生绿色荧光。线粒体膜电位的下降是细胞凋亡早期的一个标志性事件。通过JC-1从红色荧光到绿色荧光的转变可以很容易地检测到细胞膜电位的下降,同时也可以用JC- 1从红色荧光到绿色荧光的转变作为细胞凋亡早期的一个检测指标。
操作步骤（仅供参考）：
阳性对照：
CCCP（10mM ）推荐按照 1 ∶1000 的比例加入到细胞培养液中，稀释至 10μM ， 处理细胞 20 分钟。随后按照下述方法装载 JC-1 ，进行线粒体膜电位的检测。对于大多数细胞，通常 10μM CCCP 处理 20 分钟后线粒体的膜电位会完全丧失，JC-1 染色后观察应呈绿色荧光；而正常的细胞经 JC-1 染色后应显示红色荧光。对于特定的细胞，CCCP 的作用浓度和作用时间可能有所不同，需自行参考相关文献资料决定。
悬浮细胞：
（1）取 10～60 万细胞，重悬于 0.5mL 细胞培养液中，细胞培养液中可以含血清和酚红。
（2）加入 0.5mL 1~5μg/mL JC-1 工作液，颠倒数次混匀。细胞培养箱中 37 ℃孵育 20 分钟。
（3） 37℃孵育结束后，600g，4 ℃离心 3～4 分钟，沉淀细胞。弃上清，注意尽量不要吸除细胞。
（4）用提前预冷的PBS或其它适当溶液洗涤 2 次：重悬细胞，600g 4 ℃离心 3～ 4 分钟，沉淀细胞，弃上清。
（5）再用适量PBS或其它适当溶液重悬后，用荧光显微镜或激光共聚焦显微镜观察，也可以用荧光分 光光度计检测或流式细胞仪分析。
贴壁细胞：
注意：对于贴壁细胞，如果希望采用荧光分光光度计或流式细胞仪检测，可以先收集细胞，重悬后参考悬浮细胞的检测方法。
（1）对于六孔板的一个孔，吸除培养液，根据实验需求可以用 PBS 或其它适当溶液洗涤细胞一 次，加入 1mL 细胞培养液。细胞培养液中可以含有血清和酚红。
（2）加入 1mL 1~5μg/mL JC-1 工作液，充分混匀。细胞培养箱中 37℃孵育 20 分钟。
（3）37℃孵育结束后，吸除上清，用提前预冷的PBS或其它适当溶液洗涤 2 次。
（4）加入 2mL 细胞培养液，培养液中可以含有血清和酚红。
（5）荧光显微镜或激光共聚焦显微镜下观察。
纯化的线粒体：
（1）0.9mL 0.2~1μg/mL JC-1 工作液中加入 0.1mL 总蛋白量为 10～100 μg 纯化的线粒体。
（2）用荧光分光光度计或荧光酶标仪检测：混匀后直接用荧光分光光度计进行时间扫描（time scan），激发波长为 485nm ，发射波长为 590nm 。如果使用荧光酶标仪，激发波长不能设置为 485nm 时，可以在 475～520nm 范围内设置激发波长。
（3）用荧光显微镜或激光共聚焦显微镜观察 。
荧光观测和结果分析：
检测 JC-1 单体时可以把激发光设置为 490nm ，发射光设置为 530nm ；检测 JC-1 聚合物时，可以把激发光设置为 525nm ，发射光设置为 590nm 。
注意：此处测定荧光时不必把激发光和发射光设置在最大激发波长和最大发射波长。如使用荧光显微 镜观察，检测 JC-1 单体时可以参考观察其它绿色荧光时的设置，如观察 GFP 或 FITC 时的设置；检测 JC-1 聚合物时可以参考观察其它红色荧光，如碘化丙啶或 Cy3 时的设置。出现绿色荧光说明线粒体膜电位下降， 并且该细胞很可能处于细胞凋亡早期。出现红色荧光说明线粒体膜电位比较正常，细胞的状态也比较正常。
注意事项： JC-1 探针装载完并洗涤后尽量在 30 分钟内完成后续检测。在检测前需冰浴保存。
使用本产品的案例（仅供参考）
The normal human fetal hepatocyte cell line/L-02（10 μg/mL JC-1, 37°C; PBS重悬）
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
实验图
暂无详情
Tian Y, et al. Neurotherapeutics. 2020 Oct;17(4)1796-1812.
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BIOMEDICINE & PHARMACOTHERAPY
PMID：
37201263
UBXN1 promotes liver tumorigenesis by regulating mitochondrial homeostasis
点击查看 >>
Author：
Jiao Kun, Xu Guiqin, Liu Yun, Yang Zhaojuan, Xiang Lvzhu, Chen Zehong, Xu Chen, Zuo You, Wu Zhibai, Zheng Ningqian, Xu Wangjie, Zhang Li, Liu Yongzhong
IF：
7.4000
Publish_to：
Journal of Translational Medicine
PMID：
38773518
Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy
点击查看 >>
Author：
Wang Lei, Tang Xue-qing, Shi Yang, Li Hui-min, Meng Zi-yu, Chen Hui, Li Xiao-han, Chen Yong-chao, Liu Heng, Hong Yang, Xu Heng-hui, Liu Ling, Zhao Limin, Han Wei-na, Liu Xin, Zhang Yong
IF：
7.1690
Publish_to：
ACTA PHARMACOLOGICA SINICA
PMID：
35948750
Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells
点击查看 >>
Author：
Jin Huang, Liping Zou, Meng Bao, Qiwen Feng, Wei Xia, Changhong Zhu
IF：
7.1290
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
36508839
NQO1 promotes osteogenesis and suppresses angiogenesis in DPSCs via MAPK pathway modulation
点击查看 >>
Author：
Wang Wanqing, Yang Haoqing, Fan Zhipeng, Shi Ruitang
IF：
7.1000
Publish_to：
Stem Cell Research & Therapy
PMID：
39285500
Isorhamnetin protects porcine oocytes from zearalenone-induced reproductive toxicity through the PI3K/Akt signaling pathway
点击查看 >>
Author：
Li Xiaoya, Duan Jiaxin, Wang Shiyou, Cheng Jianyong, Chen Huali, Zhang Zelin, Yang Li, Hua Rongmao, Li Qingwang
IF：
7.0000
Publish_to：
Journal of Animal Science and Biotechnology
PMID：
36732843
A highly sensitive and selective artificial nanochannel for in situ detection of hydroxyl radicals in single living cell
点击查看 >>
Author：
Feifeng Yang, Yue Zhu, Congyu Zhang, Ziyan Yang, Jia Yuan, Qing Zhu, Shushu Ding
IF：
6.9110
Publish_to：
ANALYTICA CHIMICA ACTA
PMID：
36368825
Mesoporous tantalum oxide nanomaterials induced cardiovascular endothelial cell apoptosis via mitochondrial-endoplasmic reticulum stress apoptotic pathway
点击查看 >>
Author：
Yuanyong Jiao, Xiwei Zhang, Hongyu Yang, Hao Ma, Junjie Zou
IF：
6.8190
Publish_to：
DRUG DELIVERY
PMID：
36533874
Exposure to 4-nonylphenol compromises Leydig cell development in pubertal male mice
点击查看 >>
Author：
Shanhui Tao, Zhiang Yao, Huitao Li, Yiyan Wang, Xinyi Qiao, Yang Yu, Yang Li, Yangyang Ning, Ren-shan Ge, Shijun Li
IF：
6.8000
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
37866035
D-β-Hydroxybutyrate Dehydrogenase Mitigates Diabetes-Induced Atherosclerosis through the Activation of Nrf2
点击查看 >>
Author：
Jie Lin, Qian Ren, Fanjie Zhang, Jing Gui, Xin Xiang, Qin Wan
IF：
6.7000
Publish_to：
THROMBOSIS AND HAEMOSTASIS
PMID：
37399841
Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy
点击查看 >>
Author：
Zhiguo Mao, Liyu Tian, Jiao Liu, Qian Wu, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto
IF：
6.6560
Publish_to：
PHYTOMEDICINE
PMID：
35512628
Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated NLRP3 Deubiquitination
点击查看 >>
Author：
Lin Liu, Yongwu Yang, Rui Fang, Weining Zhu, Jingxue Wu, Xiaoyun Li, Jay V. Patankar, Wei Li
IF：
6.6000
Publish_to：
Cells
PMID：
34943932
Nanoplastics aggravate the toxicity of arsenic to AGS cells by disrupting ABC transporter and cytoskeleton
点击查看 >>
Author：
Peichun Lin, Yitao Guo, Lei He, Xiuchun Liao, Xueru Chen, Liuying He, Zifan Lu, Zhong-Ji Qian, Chunxia Zhou, Pengzhi Hong, Shengli Sun, Chengyong Li
IF：
6.2910
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
34634601
The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption
点击查看 >>
Author：
Ying Yang, Hui-Yun Chen, Hua Hao, Ke-Jian Wang
IF：
6.2080
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
35628312
Hydrogen sulfide attenuates PM2.5-induced COPD by inhibiting cellular senescence via the Klotho/Parkin-mediated mitophagy signaling pathway
点击查看 >>
Author：
Ying Wang, Guoqing Han, Jin Yang, Lixiang Xue, Yahong Chen
IF：
6.2000
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
40088608
Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia
点击查看 >>
Author：
Katie Hege Hurrish, Xinan Qiao, Xinyu Li, Yongwei Su, Jenna Carter, Jun Ma, Hasini A. Kalpage, Maik Hüttemann, Holly Edwards, Guan Wang, Seongho Kim, Alan Dombkowski, Xun Bao, Jing Li, Jeffrey W. Taub, Yubin Ge
IF：
6.1000
Publish_to：
BIOCHEMICAL PHARMACOLOGY
PMID：
36208684
Spermidine Supplementation Effectively Improves the Quality of Mouse Oocytes After Vitrification Freezing
点击查看 >>
Author：
Li Wang, Weijian Li, Yalan Liu, Airixiati Dilixiati, Zhanzhan Chang, Yibai Liang, Yuhan Wang, Xiuling Ma, Ling Tang, Zhi He, Yuan Zhang, Xuguang Wang
IF：
6.0000
Publish_to：
Antioxidants
PMID：
40002410
Anticancer effect of rationally designed α-helical amphiphilic peptides
点击查看 >>
Author：
Fang Pan, Yueping Li, Yujie Ding, Songwei Lv, Rongrong You, Roja Hadianamrei, Mhd Anas Tomeh, Xiubo Zhao
IF：
5.9990
Publish_to：
COLLOIDS AND SURFACES B-BIOINTERFACES
PMID：
36174494
Sesamol Attenuates Scopolamine-Induced Cholinergic Disorders, Neuroinflammation, and Cognitive Deficits in Mice
点击查看 >>
Author：
Duo Yun, Yajie Wang, Yuyu Zhang, Mengzhen Jia, Tianzhi Xie, Yihang Zhao, Cong Yang, Weixuan Chen, Rui Guo, Xuebo Liu, Xiaoshuang Dai, Zhigang Liu, Tian Yuan
IF：
5.8950
Publish_to：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：
36239029
Quercitrin Attenuates Acetaminophen-Induced Acute Liver Injury by Maintaining Mitochondrial Complex I Activity
点击查看 >>
Author：
Xiong Weichen, Yuan Zixin, Wang Tianshun, Wu Songtao, Xiong Yiyi, Yao Yunfeng, Yang Yanfang, Wu Hezhen
IF：
5.8110
Publish_to：
Frontiers in Pharmacology
PMID：
34025394
Metformin ameliorates thymus degeneration of mice by regulating mitochondrial function
点击查看 >>
Author：
Shu-ping Yang, Qing Su, Ya-ru Zhang, Yun Sun, Yu-rong Chai
IF：
5.7140
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
35395467
Polyunsaturated Fatty Acids in Quinoa Induce Ferroptosis of Colon Cancer by Suppressing Stemness
点击查看 >>
Author：
Songtao Li, Man Ding, Mangmang Feng, Xiaxia Fan, Zhuoyu Li
IF：
5.7000
Publish_to：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：
38991049
Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy
点击查看 >>
Author：
Yi-Xiang Hong, Wei-Yin Wu, Fei Song, Chan Wu, Gui-Rong Li, Yan Wang
IF：
5.6820
Publish_to：
Aging-US
PMID：
34175838
PP1A prevents ROS-induced pyroptosis by inhibiting MAPK/caspase-3 in mouse adipose tissue
点击查看 >>
Author：
Yizhe Chen, Meng Che, Chaowei Li, Yizhou Li, Tiantian Zhang, Xinjian Li, Chao Sun
IF：
5.6220
Publish_to：
FEBS Journal
PMID：
35080339
The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of primary Sjögren’s syndrome
点击查看 >>
Author：
Peng Yu, Wu Xunyao, Zhang Shulan, Deng Chuiwen, Zhao Lidan, Wang Mu, Wu Qingjun, Yang Huaxia, Zhou Jiaxin, Peng Linyi, Luo Xuan, Chen Yingying, Wang Anqi, Xiao Qiufeng, Zhang Wen, Zhao Yan, Zeng Xiaofeng, Fei Yunyun
IF：
5.6060
Publish_to：
ARTHRITIS RESEARCH & THERAPY
PMID：
35854322
S100A4 reprofiles lipid metabolism in mast cells via RAGE and PPAR-污 signaling pathway
点击查看 >>
Author：
Mo Shihui, Yan Shirong, Li Jing, He Jingjing, Wu Tongqian, Tao Tian, Wang Chenyu, Yu Fang
IF：
5.6000
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
38280333
High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis
点击查看 >>
Author：
Li Yaoqi, Chen Qianqian, Liu Yinai, Bi Liuliu, Jin Libo, Xu Ke, Peng Renyi
IF：
5.5610
Publish_to：
APOPTOSIS
PMID：
35596834
Inactivation effects and mechanism of ohmic heating on Bacillus cereus
点击查看 >>
Author：
Lihong Jia, Lele Shao, Yijie Zhao, Yingying Sun, Xingmin Li, Ruitong Dai
IF：
5.4000
Publish_to：
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
PMID：
36774686
The petroleum ether extract of Brassica rapa L. induces apoptosis of lung adenocarcinoma cells via the mitochondria-dependent pathway
点击查看 >>
Author：
Xierenguli Halike, Jinyu Li, Pengfei Yuan, Kaimeiliya Yasheng, Min Chen, Lijie Xia, Jinyao Li
IF：
5.3960
Publish_to：
Food & Function
PMID：
34523644
Hemiprotonic ph-ph+ with two targets inhibits metastatic breast cancer and concurrent candidiasis
点击查看 >>
Author：
Jingli Li, Zizhen Zhao, Dongmei You, Yafang Xie, Yixiao Feng, Xiaorong Li, Zhihong Cui, Ling Fuai
IF：
5.3000
Publish_to：
BIOCHEMICAL PHARMACOLOGY
PMID：
38942090
Citrus Carotenoid Extracts Exert Anticancer Effects through Anti-Proliferation, Oxidative Stress, and Mitochondrial-Dependent Apoptosis in MCF-7 Cells
点击查看 >>
Author：
Juanjuan Wei, Yurong Li, Zimao Ye, Yi Li, Zhiqin Zhou
IF：
5.2000
Publish_to：
Foods
PMID：
37761178
EPS364, a Novel Deep-Sea Bacterial Exopolysaccharide, Inhibits Liver Cancer Cell Growth and Adhesion
点击查看 >>
Author：
Yun Wang, Ge Liu, Rui Liu, Maosheng Wei, Jinxiang Zhang, Chaomin Sun
IF：
5.1180
Publish_to：
Marine Drugs
PMID：
33809909
Phytosphingosine inhibits the growth of lung adenocarcinoma cells by inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo
点击查看 >>
Author：
Qi Cai, Min Chen, Bo Wang, Jin Wang, Lijie Xia, Jinyao Li
IF：
5.1000
Publish_to：
CHEMICO-BIOLOGICAL INTERACTIONS
PMID：
37956922
Melatonin improves the first cleavage of parthenogenetic embryos from vitrified–warmed mouse oocytes potentially by promoting cell cycle progression
点击查看 >>
Author：
Pan Bo, Qazi Izhar Hyder, Guo Shichao, Yang Jingyu, Qin Jianpeng, Lv Tianyi, Zang Shengqin, Zhang Yan, Zeng Changjun, Meng Qingyong, Han Hongbing, Zhou Guangbin
IF：
5.0320
Publish_to：
Journal of Animal Science and Biotechnology
PMID：
34266479
Nardoguaianone L Isolated from Nardostachys jatamansi Improved the Effect of Gemcitabine Chemotherapy via Regulating AGE Signaling Pathway in SW1990 Cells
点击查看 >>
Author：
Yi-Dan Zheng, Li-Mei Ma, Jin-Jian Lu, Tian Chai, Mohammad Reza Naghavi, Jun-Yi Ma, Chun-Yan Sang, Jun-Li Yang
IF：
4.9270
Publish_to：
MOLECULES
PMID：
36296442
Curcumin-Loaded Macrophage-Derived Exosomes Effectively Improve Wound Healing
点击查看 >>
Author：
Daoyong Li, Chuanjie Zhang, Zhanshan Gao, Nan Xia, Chao Wu, Chang Liu, He Tian, Xifan Mei
IF：
4.9000
Publish_to：
MOLECULAR PHARMACEUTICS
PMID：
37525890
Magnesium alleviates extracellular histone-induced apoptosis and defective bacterial phagocytosis in macrophages by regulating intracellular calcium signal
点击查看 >>
Author：
Tao Zhong, Sainan Chen, Ke Deng, Jianbin Guan, Jiaqi Zhang, Furong Lu, Maoyou Shichen, Ronggui Lv, Zhifeng Liu, Yong Liu, Ping Chang, Zhanguo Liu
IF：
4.8000
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
38547771
Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway
点击查看 >>
Author：
Kaipeng Jin, Chengchun Shen, Wei Yu, Jinti Lin, Jian Zhu, Huimin Tao, Bing Liu
IF：
4.7000
Publish_to：
CHEMICO-BIOLOGICAL INTERACTIONS
PMID：
39954838
Neuroprotection of Truncated Peptide IIAVE from Isochrysis zhanjiangensis: Quantum Chemical, Molecular Docking, and Bioactivity Studies
点击查看 >>
Author：
Qiuqi Liu, Liyuan Lin, Huijuan Li, Zhong-Ji Qian
IF：
4.6000
Publish_to：
MOLECULES
PMID：
38338436
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes
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Author：
Xu Linxin, Xu Chaofei, Liu Xiangyang, Li Xiaoyu, Li Ting, Yu Xiaochen, Xue Mei, Yang Jing, Kosmas Constantine E., Moris Dimitrios, Sanchis-Gomar Fabian, Yoshida Naofumi, Berger Nathan A., Aronow Wilbert S., Sun Bei, Chen Liming
IF：
4.5660
Publish_to：
Frontiers in Physiology
PMID：
34777009
Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer’s disease mice and glutamate-injured HT22 cells
点击查看 >>
Author：
Yang Sixia, xie Zeping, Pei Tingting, zeng Yi, Xiong Qiaowu, Wei Hui, Wang Yong, Cheng Weidong
IF：
4.5460
Publish_to：
Chinese Medicine
PMID：
35787281
Antiviral innovations in largemouth bass aquaculture: Unveiling the potential of arctigenin derivatives against Micropterus Salmoides rhabdovirus
点击查看 >>
Author：
Guang-Lu Liu, Wenke Dong, Chunjie Wang, Zhenjie Fan, Na Liu, Wanyu Wang, Yahong Chen
IF：
4.5000
Publish_to：
AQUACULTURE
PMID：
Antioxidant Activity and Anti-Apoptotic Effect of the Small Molecule Procyanidin B1 in Early Mouse Embryonic Development Produced by Somatic Cell Nuclear Transfer
点击查看 >>
Author：
Wei Gao, Tingting Yu, Guomeng Li, Wei Shu, Yongxun Jin, Mingjun Zhang, Xianfeng Yu
IF：
4.4120
Publish_to：
MOLECULES
PMID：
34684730
Inhibition of CISD2 enhances sensitivity to doxorubicin in diffuse large B-cell lymphoma by regulating ferroptosis and ferritinophagy
点击查看 >>
Author：
Chaofeng Zhang, Siting Zhan, Yanjun He, Zhiqun Pan, Zhongyi You, Xiongpeng Zhu, Qi Lin
IF：
4.4000
Publish_to：
Frontiers in Pharmacology
PMID：
39605902
Perfluorodecanoic acid induces meiotic defects and deterioration of mice oocytes in vitro
点击查看 >>
Author：
Shu-Zi Deng, Chang-Long Xu, Zhong-Feng Xu, Li-Ying Zhou, Shu-Juan Xie, Kang-Na Wei, Yuan-Chang Jin, Zhao-Cheng Zeng, Xiang-Jun Yang, Shu-Hua Tan, Hai-Long Wang
IF：
4.2210
Publish_to：
TOXICOLOGY
PMID：
34358620
Berberine-photodynamic therapy sensitizes melanoma cells to cisplatin-induced apoptosis through ROS-mediated P38 MAPK pathways
点击查看 >>
Author：
Xiaotong Wang, Qianyi Gong, Changfeng Song, Jiaping Fang, Yun Yang, Xin Liang, Xuan Huang, Jianwen Liu
IF：
4.2190
Publish_to：
TOXICOLOGY AND APPLIED PHARMACOLOGY
PMID：
33716044
TFEB activator protects against ethanol toxicity-induced cardiac injury by restoring mitophagy and autophagic flux
点击查看 >>
Author：
Mengxue Zhao, Ruocheng Zhang, Xiuzhu Chen, Peixuan Li, Hui Yang, Bin Gao, Baoxin Li, Weina Zhou, Yuanyuan Wang, Yunliang Zhang, Li Zhong, Rui Guo
IF：
4.2000
Publish_to：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
PMID：
39805395
Synthesis and Antitumor Activities of Novel Mitochondria-Targeted Dihydroartemisinin Ether Derivatives
点击查看 >>
Author：
Cangcang Xu, Linfan Xiao, Peiyu Lin, Xiyue Yang, Xin Zou, Lingli Mu, Xiaoping Yang
IF：
4.1320
Publish_to：
ACS Omega
PMID：
36340114
Integrated proteomic analysis to explore the molecular regulation mechanism of IL-33 mRNA increased by black carbon in the human endothelial cell line EA.hy926
点击查看 >>
Author：
Wanyu Jiang, Hongqian Chu, Zekang Li, Jianhong Ge, Xiaoyun Wang, Jianjun Jiang, Qianqian Xiao, Qinghe Meng, Yaxin Lou, Weidong Hao, Xuetao Wei
IF：
4.1090
Publish_to：
ENVIRONMENTAL TOXICOLOGY
PMID：
35776887
miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease
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Author：
Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zhu
IF：
4.1010
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
PMID：
33649797
1,2,4-Triazole benzamide derivative TPB against Gaeumannomyces graminis var. tritici as a novel dual-target fungicide inhibiting ergosterol synthesis and adenine nucleotide transferase function
点击查看 >>
Author：
Limin Wang, Xiaoyu Song, Yi-nan Cheng, Senxiang Cheng, Tong Chen, Honglian Li, Jingming Yan, Xiafei Wang, Haifeng Zhou
IF：
4.1000
Publish_to：
PEST MANAGEMENT SCIENCE
PMID：
38010196
The semenogelin I-derived peptide SgI-52 in seminal plasma participates in sperm selection and clearance by macrophages
点击查看 >>
Author：
Chaoyong He, Jiankai Li, Zhao Wu, Chuncheng Lu, Zhuo Huang, Ning Luo, Shipeng Fan, Jihong Shen, Xiaodong Liu, Hui Zhao
IF：
3.8670
Publish_to：
PEPTIDES
PMID：
35427699
Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress
点击查看 >>
Author：
Gao Wei, Jin Yongxun, Hao Jindong, Huang Siyi, Wang Dongxu, Quan Fushi, Zhang Mingjun, Zhang Jiabao, Ren Wenzhi, Yu Xianfeng
IF：
3.8400
Publish_to：
BIOSCIENCE REPORTS
PMID：
33844009
Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora
点击查看 >>
Author：
Li Yangbo, He Pengzhan, Chen Ying, Hu Jiaming, Deng Beiying, Liu Chuan, Yu Baoping, Dong Weiguo
IF：
3.8000
Publish_to：
Scientific Reports
PMID：
38844824
Molecular mechanisms of quinalizarin induces apoptosis and G0/G1 cell cycle of human esophageal cancer HCE-4 cells depends on MAPK. STAT3. and NF-κB signaling pathways
点击查看 >>
Author：
Zang YQ. Zhai YQ. Feng YY. Ju XY. Zuo F
IF：
3.7790
Publish_to：
Environ Toxicol
PMID：
33030807
Neuroprotective effect of hyperoside in MPP+/MPTP -induced dopaminergic neurodegeneration
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Author：
Xu Xing-Jie, Pan Tao, Fan Hui-Jie, Wang Xu, Yu Jie-Zhong, Zhang Hai-Fei, Xiao Bao-Guo, Li Zhen-Yu, Zhang Bo, Ma Cun-Gen, Chai Zhi
IF：
3.6550
Publish_to：
METABOLIC BRAIN DISEASE
PMID：
36576692
Gypenosides (GPs) alleviates hypoxia-induced injury in PC12 cells and enhances tolerance to anoxia in C57BL/6 mice
点击查看 >>
Author：
Cheng-Bo Wang, Ming Zhao, Jun Wang, Jiao-Tai Shi, Wei-Feng Wang, Ying Zhang, Xian-Hua Meng, Chun-Yan Sang, Ling-Ling Zhu, Jun-Li Yang
IF：
3.6540
Publish_to：
JOURNAL OF FOOD BIOCHEMISTRY
PMID：
36226816
The apoptosis induced by CdTe quantum dots through the mitochondrial pathway in dorsal root ganglion cell line ND7/23
点击查看 >>
Author：
Changcun Bai, Tingting Wei, Lingyue Zou, Na Liu, Xiaoquan Huang, Meng Tang
IF：
3.6280
Publish_to：
JOURNAL OF APPLIED TOXICOLOGY
PMID：
35083762
Involvement of NEAT1/PINK1-mediated mitophagy in chronic obstructive pulmonary disease induced by cigarette smoke or PM2.5
点击查看 >>
Author：
Qi Lin, Chao-Feng Zhang, Jin-Ling Guo, Jian-Lin Su, Zhen-Kun Guo, Huang-Yuan Li
IF：
3.6160
Publish_to：
Annals of Translational Medicine
PMID：
35433942
Neutrophil membrane-coated multifunctional biomimetic nanoparticles for spinal cord injuries
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Author：
Hongyi Zhu, Feng Cai, Ziang Li, Lichen Zhang, Xindie Zhou, Jiapei Yao, Wei Wang, Liang Zhou, Xinzhao Jiang, Kun Xi, Yong Gu, Liang Chen, Yidi Zhou
IF：
3.6000
Publish_to：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
PMID：
39298153
p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells
点击查看 >>
Author：
Shanshan Li, Meng Wang, Youlin Wang, Yuting Guo, Xiaoxiao Tao, Xuncui Wang, Yin Cao, Shasha Tian, Qinglin Li
IF：
3.5000
Publish_to：
TOXICOLOGY IN VITRO
PMID：
33737050
Melatonin Promotes in vitro Development of Vitrified-Warmed Mouse GV Oocytes, Potentially by Modulating Phosphorylation of Drp1
点击查看 >>
Author：
Qin Jianpeng, Guo Shichao, Yang Jinyu, Qazi Izhar Hyder, Pan Bo, Lv Tianyi, Zang Shengqin, Fang Yi, Zhou Guangbin
IF：
3.4120
Publish_to：
Frontiers in Veterinary Science
PMID：
34631868
Melatonin-induced upregulation of telomerase activity interferes with macrophage mitochondrial metabolism and suppresses NLRP3 inflammasome activation in the treatment of Pneumonia
点击查看 >>
Author：
Wei Jiang, Jun Liu, Xuequn Zhao, Wenjie Yang
IF：
3.4000
Publish_to：
Heliyon
PMID：
38665558
Pleomorphic adenoma gene 1 (PLAG1) promotes proliferation and inhibits apoptosis of bovine primary myoblasts through the PI3K-Akt signaling pathway
点击查看 >>
Author：
Wang Jian, Huang Yongzhen, Xu Jiawei, Yue Binglin, Wen Yifan, Wang Xiao, Lei Chuzhao, Chen Hong
IF：
3.3380
Publish_to：
JOURNAL OF ANIMAL SCIENCE
PMID：
35325183
Luteolin Isolated from Polygonum cuspidatum Is a Potential Compound against Nasopharyngeal Carcinoma
点击查看 >>
Author：
Yu Xiong, Wenliang Zhong, Jie Liu, Bo Cheng, Jingying Fan, Fangliang Zhou, Lan He, Daofa Tian, Yingchun He
IF：
3.2460
Publish_to：
Biomed Research International
PMID：
36588531
Tilianin enhances the antitumor effect of sufentanil on non-small cell lung cancer
点击查看 >>
Author：
Huixia Chen, Yulin Wu, Jiazheng Wang, Yike Li, Yongxue Chen, Xinbo Wang, Hangyu Lv, Xinyan Liu
IF：
3.2000
Publish_to：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
PMID：
38952040
Neurotoxicity Profiling of Aluminum Salt-Based Nanoparticles as Adjuvants for Therapeutic Cancer Vaccine
点击查看 >>
Author：
Chen Chen, Changying Xue, Jiaxuan Jiang, Shisheng Bi, Zurui Hu, Ge Yu, Bingbing Sun, Chuanbin Mao
IF：
3.1000
Publish_to：
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
PMID：
38272670
Phosphatase UBLCP1 is required for the growth, virulence and mitochondrial integrity of Toxoplasma gondii
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Author：
Kaiyin Sheng, Kaiyue Song, Yimin Yang, Haiyan Wu, Zhendong Du, Xueqiu Chen, Yi Yang, Guangxu Ma, Aifang Du
IF：
3.0000
Publish_to：
Parasites & Vectors
PMID：
40156024
Antimicrobial peptide 17BIPHE2 inhibits the proliferation of lung cancer cells in vitro and in vivo by regulating the ERK signaling pathway
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Author：
Tingting Yang, Jun Li, Qinqin Jia, Shisheng Zhan, Qiannan Zhang, Yarong Wang, Xiuqing Wang
IF：
2.9670
Publish_to：
Oncology Letters
PMID：
33981363
Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
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Author：
Ying Liu, Shiting Yu, Xin Xing, Juhui Qiao, Yiqiu Yin, Jiawen Wang, Meichen Liu, Wei Zhang
IF：
2.9520
Publish_to：
Molecular Medicine Reports
PMID：
34713297
(2E)-1-(2,4,6-Trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one,a Chalcone Derivative,Promotes Apoptosis by Suppressing RAS-ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells
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Author：
Meigui Zhang, Jing Li, Ruixia Ma, Jiahui Xi, Lili Xi, Baoxin Zhang, Jing Tian, Zhongtian Bai
IF：
2.9000
Publish_to：
CHEMISTRY & BIODIVERSITY
PMID：
37314937
Honokiol Reduces Mitochondrial Dysfunction and Inhibits Apoptosis of Nerve Cells in Rats with Traumatic Brain Injury by Activating the Mitochondrial Unfolded Protein Response
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Author：
Sun Guang-wei, Ding Tian-yi, Wang Meng, Hu Chang-long, Gu Jiang-jiang, Li Jie, Qiu Tao
IF：
2.8660
Publish_to：
JOURNAL OF MOLECULAR NEUROSCIENCE
PMID：
36508141
Decitabine combined with cold atmospheric plasma induces pyroptosis via the ROS/Caspase-3/GSDME signaling pathway in Ovcar5 cells
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Author：
Liang Du, Huiyun Ming, Zhuna Yan, Jinwu Chen, Wencheng Song, Haiming Dai
IF：
2.8000
Publish_to：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
PMID：
38513927
Ginsenoside Rb3 Alleviates the Toxic Effect of Cisplatin on the Kidney during Its Treatment to Oral Cancer via TGF-β-Mediated Mitochondrial Apoptosis
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Author：
Wen-Jie Wu, Yu-Fang Tang, Shuang Dong, Jie Zhang
IF：
2.6300
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
33510805
Growth Hormone Improves Ovarian Follicle Health in Premature Ovarian Failure Mice by Reducing Apoptosis
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Author：
Hong Ziwei, Ni Xinyi, Zhou Liying, Ji Hong, Yang Daowei, Sui Hongshu, Wang Hailong
IF：
2.6000
Publish_to：
Reproductive Sciences
PMID：
40029544
Lipid discovered in American ginseng alleviates doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte ferroptosis
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Author：
Kaiqing Hu, Huan Wang, Haiyang Wang, Taiping Li, Lu Liu, Haiyan Zhang, Zhenyu Li, Songsong Wang, Liwen Han
IF：
2.5000
Publish_to：
FITOTERAPIA
PMID：
38945490
Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway
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Author：
Bin Tang, Wei Ni, Jiqin Zhou, Yating Ling, Dongdong Niu, Xiaorui Lu, Tianyan Chen, Murugan Ramalingam, Jiabo Hu
IF：
2.4660
Publish_to：
TISSUE & CELL
PMID：
34482185
Hirsutanol A inhibits T‑acute lymphocytic leukemia Jurkat cell viability through cell cycle arrest and p53‑dependent induction of apoptosis
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Author：
Fangfang Zhong, You Yang, Danwei Ren, Sili Long, Xiang Qin, Jing Liu, Yan Zeng, Wenjian Lan, Wenzhe Ma, Wenjun Liu
IF：
2.4470
Publish_to：
Experimental and Therapeutic Medicine
PMID：
34055057
α-Linolenic acid promotes testosterone synthesis by improving mitochondrial function in primary rooster Leydig cells
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Author：
Xuerui Chang, Danyang Li, Yong Guo, Xihui Sheng, Xiangguo Wang, Kai Xing, Longfei Xiao, Xueze Lv, Cheng Long, Xiaolong Qi
IF：
2.4000
Publish_to：
THERIOGENOLOGY
PMID：
39504870
BAK and ARG Have Moisturizing, Anti‐Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model
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Author：
Xufeng Jiang, Weiguo Wang, Yuqing Wei, Wenxuan Cheng, Shoulin Li, Linjing Du, Wenping Xu, Yang Zhang
IF：
2.3000
Publish_to：
Journal of Cosmetic Dermatology
PMID：
40176351
Effect of human umbilical cord mesenchymal stem cell exosomes on aerobic metabolism of human retinal pigment epithelial cells
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Author：
Liu Lian, Liang Chunlan, Fan Wei, Zhong Jingxiang
IF：
2.0290
Publish_to：
INTERNATIONAL OPHTHALMOLOGY
PMID：
36195815
Resveratrol Attenuates Sepsis-Induced Cardiomyopathy in Rats through Anti-Ferroptosis via the Sirt1/Nrf2 Pathway
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Author：
Youcheng Zeng, Guodong Cao, Liang Lin, Yixin Zhang, Xiqing Luo, Xiaoyu Ma, Akelibieke Aiyisake, Qinghong Cheng
IF：
1.9720
Publish_to：
JOURNAL OF INVESTIGATIVE SURGERY
PMID：
36576230
Magnoflorine ameliorates cartilage degradation in osteoarthritis through inhibition of mitochondrial reactive oxygen species–mediated activation of the NLRP3 inflammasome
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Author：
Yi Peng, Yue-Hui Huang, Xiao Luo, Mei-Chen Li, Qing-Qing Xiao, Lu Qiu, Qiang Fu
IF：
1.3000
Publish_to：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
PMID：
40035483
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