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阿利新蓝染色试剂盒(pH=2.5)
英文名称:Alcian Blue Stain Kit，pH 2.5
CAS:No.75881-23-1
分子式:C56H68N16S4Cl4Cu
储存条件:RT，避光保存，有效期6个月。
产品简介
| 中文名称 | 阿利新蓝染色试剂盒(pH=2.5) |
| 英文名称 | Alcian Blue Stain Kit，pH 2.5 |
| CAS | No.75881-23-1 |
| 分子式 | C56H68N16S4Cl4Cu |
| 储存条件 | RT，避光保存，有效期6个月。 |
| 规格 | 3*50ml 3*100ml |
| 单位 | 盒 |
阿利新蓝（Alcian）又称爱先蓝或阿尔辛蓝等，是一种类铜钛花青共轭染料，最初用于纺织纤维染色。这种阳离子染料与酸性基团结合，也即阿尔辛蓝与组织内含有的阴离子基团如羧基和硫酸根形成不溶性复合物。阿利新蓝由中央含铜的酞菁环与四个异硫脲基通过硫醚键相连而成。该异硫脲基呈中度碱性，使阿利新蓝带阳离子。阿利新蓝使碳水化合物着色的确切机制不明， 普遍认为是阳离子的异硫脲基通过静电与组织内的多聚阴离子相连。如含羧基和硫酸根的酸性黏液物质的羧基和硫酸根形成不溶性复合物，即染料分子中带正电荷的盐键和酸性黏液物质中带负电荷的酸性基团结合呈蓝色。
pH值为2.5时组织内的羧基电离，带有一个负电荷，与阿利新蓝中的阳离子形成盐键，是带有羧基的组织（如蛋白多糖/透明质酸以及上皮酸性黏蛋白）染色。pH值为1.0时，组织内的硫酸根电离，带有一个负电荷，与阿利新蓝中的阳离子形成盐键，使带有硫酸根的组织（如硫酸黏液物质）染色。中性黏蛋白(如胃黏膜和Brunner腺体部位的中性黏蛋白）不能与阿利新蓝反应。
该试剂盒主要由阿利新蓝染液（pH2.5）和核固红复染液组成，羧基和硫酸粘液质着蓝色，核固红衬染细胞核呈红色。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
实验图
小鼠小肠石蜡切片
酸性粘液质着蓝色，细胞核和嗜碱性物质着粉红色
酸性粘液质着蓝色，细胞核和嗜碱性物质着粉红色
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Yang Hao, Liu Qingqing, Liu Haixia, Kang Xing, Tian Haixia, Kang Yongbo, Li Lin, Yang Xiaodan, Ren Peng, Kuang Xiaoyu, Wang Xiaohui, Guo Linzhi, Tong Mingwei, Ma Jieqiong, Fan Weiping
IF：
5.1000
Publish_to：
Hepatology Communications
PMID：
38466881
The Gut Microbiota Metabolite Butyrate Modulates Acute Stress-Induced Ferroptosis in the Prefrontal Cortex via the Gut–Brain Axis
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Author：
Zhen Wang, Xiaoying Ma, Weibo Shi, Weihao Zhu, Xiaowei Feng, Hongjian Xin, Yifan Zhang, Bin Cong, Yingmin Li
IF：
4.9000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
40004161
Tetrastigma hemsleyanum polysaccharide ameliorated ulcerative colitis by remodeling intestinal mucosal barrier function via regulating the SOCS1/JAK2/STAT3 pathway
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Author：
Xiaodan Bao, Youying Tang, Yishan Lv, Siyu Fu, Liu Yang, Yuchi Chen, Mingyuan Zhou, Bingqi Zhu, Zhishan Ding, Fangmei Zhou
IF：
4.8000
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
38851163
HMGB1-mediated macrophage regulation of NF-κB activation and MMP3 upregulation in nucleus pulposus cells: A critical mechanism in the vicious cycle of intervertebral disc degeneration
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Author：
Shixin Lu, Ming Li, Ziying Cheng, Yuwei Liang, Junshen Huang, Jiajun Huang, Kun Wang, Dengbo Yao, Enming Chen, Peng Wang, Yuxi Li, Lin Huang
IF：
4.4000
Publish_to：
CELLULAR SIGNALLING
PMID：
39880103
MST1 knockdown inhibits osteoarthritis progression through Parkin-mediated mitophagy and Nrf2/NF-κB signalling pathway
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Author：
Hantao Ye, Tingwen Cai, Yang Shen, Lin Zhao, Haojie Zhang, Jianxin Yang, Feida Li, Jiaoxiang Chen, Xiaolong Shui
IF：
4.3000
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
38842136
PPARγ/NF-κB axis contributes to cold-induced resolution of experimental colitis and preservation of intestinal barrier
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Author：
Yuzhu Di, Hui Li, Jia Yang, Minghao Feng, Shuang Wang, Wanying Li, Xiuqing Wang, Yuxin Zhu, Yan Shi, Rennan Feng, Bo Qu
IF：
4.2000
Publish_to：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
PMID：
38960052
Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate diquat-induced intestinal barrier dysfunction in C57BL/6 mice through their antioxidant activity
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Author：
乔磊
IF：
4.1710
Publish_to：
PMID：
32243488
Histopathology and transcriptome profiling reveal features of immune responses in gills and intestine induced by Spring viremia of carp virus
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Author：
Ping Ouyang, Qiunan Li, Shuya Liu, Yankai Li, Shuhan Li, Yongheng Zhou, Peng jia, Defang Chen, Xiaoli Huang, Yi Geng
IF：
4.1000
Publish_to：
FISH & SHELLFISH IMMUNOLOGY
PMID：
38944254
Thermo-responsible PNIPAM-grafted polystyrene microspheres for mesenchymal stem cells culture and detachment
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Author：
Yuanyuan Zhao, Zida Cao, Jingwei Zhang, Jia Tian, Haibo Cai
IF：
3.9000
Publish_to：
Biomedical Materials
PMID：
39312938
Establishment of immortalized rabbit bone marrow mesenchymal stem cells and a preliminary study of their osteogenic differentiation capability
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Author：
Yao Zhang, Chang Xu, Yun Huang, Dongmei Tan, Wenping Luo, Yan Zhang, Yi Tan
IF：
3.8000
Publish_to：
Animal Models and Experimental Medicine
PMID：
39592420
Long-term stability, high strength, and 3D printable alginate hydrogel for cartilage tissue engineering application
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Author：
Yun Chu, Lei Huang, Wangping Hao, Tongtong Zhao, Haitao Zhao, Wen Yang, Xin Xie, Lin Qian, Yanyan Chen, Jianwu Dai
IF：
3.7150
Publish_to：
Biomedical Materials
PMID：
34507313
Overexpressed miR-486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats
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Author：
Yali Xu, Lihong Huang, Zhixin Qiu, Jiaqi Zhang, Xueyi Xue, Junshan Lin
IF：
3.6000
Publish_to：
Journal of Cell Communication and Signaling
PMID：
38946723
Static Magnetic Fields Enhance the Chondrogenesis of Mandibular Bone Marrow Mesenchymal Stem Cells in Coculture Systems
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Author：
Ming Zhang, Weihao Li, Wei He, Yanhua Xu
IF：
3.4110
Publish_to：
Biomed Research International
PMID：
34873576
METTL3 inhibits BMSC apoptosis and facilitates osteonecrosis repair via an m6A-IGF2BP2-dependent mechanism
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Author：
Zhihong Xie, Hong Luo, Tao Wang, Lei Wang, Jian Zhang, Wentao Dong, Gang Liu, Fanchao Li, Qinglin Kang, Xuesong Zhu, Fei Zhang, Wuxun Peng
IF：
3.4000
Publish_to：
Heliyon
PMID：
38784565
Multifaceted Characterization of Human Embryonic Stem Cell-Derived Mesenchymal Stem/Stromal Cells Revealed Amelioration of Acute Liver Injury in NOD-SCID Mice
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Author：
Youlai Zhang, Ying He, Rufei Deng, Zhenyu Jiang, Leisheng Zhang, Yuanlin Zeng, Lijin Zou
IF：
3.3000
Publish_to：
CELL TRANSPLANTATION
PMID：
38173232
Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux
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Author：
Wei Wang, Jing-Wen Zhang, Yu-Jie Qin, Hong-Yan Li, Yu-Xiang Dai, Hong Li
IF：
3.0000
Publish_to：
Translational Vision Science & Technology
PMID：
37342053
Single-cell infrared phenomics identifies cell heterogeneity of individual pancreatic islets in mouse model
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Author：
Zhu Chao, Zhou Qing, Wang Zuqiang, Zhang Junyou, Xu Cheng, Ruan Dike
IF：
2.8000
Publish_to：
MOLECULAR BIOLOGY REPORTS
PMID：
37310547
Proteomic comparison between physiological degeneration and needle puncture model of disc generation disease
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Author：
He Shuangjun, Zhou Xinfeng, Yang Guotao, Zhou Zhangzhe, Zhang Yijian, Shao Xiaofeng, Liang Ting, Lv Nanning, Chen Jianhong, Qian Zhonglai
IF：
2.7210
Publish_to：
EUROPEAN SPINE JOURNAL
PMID：
35842490
The recombinant BMP-2 loaded silk fibroin microspheres improved the bone phenotype of mild osteogenesis imperfecta mice
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Author：
Ting Fu, Yi Liu, Zihan Wang, Yaqing Jing, Yuxia Zhao, Chenyi Shao, Zhe Lv, Guang Li
IF：
2.7000
Publish_to：
PeerJ
PMID：
37927786
Deer antler stem cells immortalization by modulation of hTERT and the small extracellular vesicles characters
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Author：
Peng Yinghua
IF：
2.6000
Publish_to：
Frontiers in Veterinary Science
PMID：
39430380
Effects of Oligomeric Proanthocyanidins on Cadmium-Induced Extracellular Matrix Damage via Inhibiting the ERK1/2 Signaling Pathway in Chicken Chondrocytes
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Author：
Jianhong Gu, Dan Liu, Anqing Gong, Xinrui Zhao, Jiatao Zhou, Panting Wang, Han Xia, Ruilong Song, Yonggang Ma, Hui Zou, Muhammad Azhar Memon, Yan Yuan, Xuezhong Liu, Jianchun Bian, Zongping Liu, Xishuai Tong
IF：
2.0000
Publish_to：
Veterinary Sciences
PMID：
40284819
A comprehensive stem cell laboratory module with blended learning for medical students at Tongji University
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Author：
Jie Xu, Zhihua Shao, Song Jia, Jihong Sha, Jiao Li, Furong Gao, Xiujuan Shi, Juan Wang, Caixia Jin, Mei Jiang, Haibin Tian, Jinfeng Cao, Hu Pu, Lei Xu, Lixia Lu
IF：
1.4000
Publish_to：
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
PMID：
38189805
The alteration of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in the knee joints of osteoarthritis mice
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Author：
Luling Wang, Caixia Pi, Jianxun Sun, Yujia Cui, Linyi Cai, Yuanchen Lan, Jinning Gu, linfeng Liu, Geru Zhang, Lianyang Guo, Zhaowei Zhang, Qiang Guo, Liwei Zheng, Jing Xie, Demao Zhang, Xuedong Zhou
IF：
0.7140
Publish_to：
JOURNAL OF HISTOTECHNOLOGY
PMID：
33480322
技术问答
（10）
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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此试剂可以用来验证ATDC5是否诱导成软骨细胞吗2025-05-01 14:45:48
您好，该试剂可用于判断是否有软骨球（胞外软骨基质）形成，对新诱导软骨细胞胞质内软骨基质前体的透明质酸、硫酸角质素等着色较差。
用试剂盒染SDS-PAGE凝胶，步骤是否与切片一致？2025-04-06 11:40:03
您好，您如果想做凝胶的糖蛋白染色，可以选购我司的另一款产品G4835-糖蛋白凝胶PAS染色试剂盒，这个试剂盒更适配。
软骨细胞染色过程中，酸化液酸化后需不需要PBS冲洗，孵育时间多少合适呢？2024-12-12 22:59:57
您好，无需PBS冲洗，可用蒸馏水或去离子水简单冲洗，在使用阿利新蓝染色液染色，孵育30min
可以用来给细菌荚膜多糖的SDS凝胶染色吗2024-11-08 16:16:02
您好，可以选购G4835-糖蛋白凝胶PAS染色试剂盒
可以对软骨整体进行染色吗，需要事先做固定脱水处理吗2024-09-27 13:40:51
您好，可以，将软骨固定在95%乙醇中3-7天，固定后的软骨标本浸入阿利新蓝染色液中，软骨组织染至蓝色，中间可更换新鲜染液，后续梯度乙醇水化后使用KOH水溶液处理软骨至清透后，保存在50%甘油中。