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英语
β-半乳糖苷酶染色试剂盒
英文名称:Senescence-Associated β-Galactosidase（SA-β-Gal） Stain Kit
储存条件:-20℃，避光保存，有效期1年。
产品简介
| 中文名称 | β-半乳糖苷酶染色试剂盒 |
| 英文名称 | Senescence-Associated β-Galactosidase（SA-β-Gal） Stain Kit |
| 储存条件 | -20℃，避光保存，有效期1年。 |
| 货期 | 2-3天 |
| 规格 | 100T |
| 单位 | 盒 |
β-半乳糖苷酶染色试剂盒(β-Galactosidase Staining Kit)是一种基于衰老时SA-β-Gal (senescence-associated β-galactosidase)活性水平上调而对衰老细胞或组织进行染色检测的试剂盒。在普通的光学显微镜下就可以观测到细胞或组织的衰老情况。本试剂盒可以用于培养细胞的衰老检测，也可以用于组织切片的衰老检测。β-半乳糖苷酶染色试剂盒以X-Gal为底物，在衰老特异性的β-半乳糖苷酶催化下会生成深蓝色产物，光学显微镜下很容易观察到变成蓝色的表达β-半乳糖苷酶的细胞或组织。本试剂盒仅染色衰老细胞，对衰老前的细胞(presenescent cells)、静止期细胞(quiescent cells)、永生细胞(immortal cells)或肿瘤细胞等不会染色。对于组织切片或组织块，可以检测的样品数量视样品的大小而定，对于普通的切片也至少足够检测100个样品，使用6孔板测定，足够测定100个样品。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
实验图
损伤造模悬浮细胞涂片酶活性位点着绿色，红色复染液复染后呈蓝色。细胞呈淡黄色或细胞本色
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Publish_to：
Food Chemistry-X
PMID：
38779498
The role of PKA/PP2B-mediated Drp1 phosphorylation and the subsequent EGFR inhibition in Cr(VI)-induced premature senescence
点击查看 >>
Author：
Siwen Li, Yu Ma, Yuehui Liang, Ningjuan Liang, Shuzi Ye, Fang Xiao
IF：
6.2910
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
33971394
Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice
点击查看 >>
Author：
Yibo Li, Hongfang Wang, Yanjing Gao, Runjiao Zhang, Qing Liu, Wenmeng Xie, Ziyu Liu, Dandan Geng, Lei Wang
IF：
6.2610
Publish_to：
Frontiers in Molecular Neuroscience
PMID：
36533129
Identification and Functional Evaluation of a Novel TBX4 Mutation Underlies Small Patella Syndrome
点击查看 >>
Author：
Ping Li, Wenli Lan, Jiaying Li, Yanping Zhang, Qiuhong Xiong, Jinpei Ye, Changxin Wu, Han Xiao
IF：
6.2080
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
35216193
β-elemene promotes the senescence of glioma cells through regulating YAP-CDK6 signaling
点击查看 >>
Author：
Danlu Yang, Xingxing Xu, Xin Wang, Wenjin Feng, Xiya Shen, Jingjing Zhang, Huitao Liu, Changnan Xie, Qian Wu, Xuemeng Miao, Yifan Guo, Hao Cai, Lihao Wu, Shuxian Zhou, Xinfei Yao, Ying Wang, Tian Xie, Zhihui Huang
IF：
6.1660
Publish_to：
American Journal of Cancer Research
PMID：
33575077
Identifying cis-Acting Elements Associated with the High Activity and Endosperm Specificity of the Promoters of Genes Encoding Low-Molecular-Weight Glutenin Subunits in Common Wheat (Triticum aestivum)
点击查看 >>
Author：
Ge Qu, Ke Wang, Junyi Mu, Jiahui Zhuo, Xinyu Wang, Shasha Li, Xingguo Ye, Yaxuan Li, Yueming Yan, Xiaohui Li
IF：
6.1000
Publish_to：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：
37919930
Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice
点击查看 >>
Author：
Bolin Chen, Runjiu Zhu, Hao Hu, Mingbin Zhan, Tingxuan Wang, Fangli Huang, Fuxin Wei, Yu Chai, Zemin Ling, Xuenong Zou
IF：
6.0810
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
35874831
Oligomeric Proanthocyanidins Ameliorate Cadmium-Induced Senescence of Osteocytes Through Combating Oxidative Stress and Inflammation
点击查看 >>
Author：
Gengsheng Yu, Zehao Wang, Anqing Gong, Xiaohui Fu, Naineng Chen, Dehui Zhou, Yawen Li, Zongping Liu, Xishuai Tong
IF：
6.0000
Publish_to：
Antioxidants
PMID：
39765843
An Evolutionary Analysis of B-Box Transcription Factors in Strawberry Reveals the Role of FaBBx28c1 in the Regulation of Flowering Time
点击查看 >>
Author：
Yuntian Ye, Yongqiang Liu, Xiaolong Li, Guangyi Wang, Quan Zhou, Qing Chen, Jiale Li, Xiaorong Wang, Haoru Tang
IF：
5.9240
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
34769196
Auricularia auricula Peptides Nutritional Supplementation Delays H2O2-Induced Senescence of HepG2 Cells by Modulation of MAPK/NF-百B Signaling Pathways
点击查看 >>
Author：
Qianwen Han, Haiyan Li, Fen Zhao, Ji＊an Gao, Xinqi Liu, Biao Ma
IF：
5.9000
Publish_to：
Nutrients
PMID：
37686763
Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegans
点击查看 >>
Author：
Mengwei Zhang, Shumao Cui, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Xin Tang, Wei Chen
IF：
5.8950
Publish_to：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：
37040550
Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation
点击查看 >>
Author：
Tao Wu, Shengmin Xu, Biao Chen, Lingzhi Bao, Jie Ma, Wei Han, An Xu, Kwan Ngok Yu, Lijun Wu, Shaopeng Chen
IF：
5.8810
Publish_to：
Nanotoxicology
PMID：
36403163
Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma
点击查看 >>
Author：
Shuangshuang Yin, Shenshen Yang, Yanming Luo, Jia Lu, Gaoyong Hu, Kailong Wang, Yingying Shao, Shiyue Zhou, Sangho Koo, Yuling Qiu, Tao Wang, Haiyang Yu
IF：
5.8580
Publish_to：
BIOCHEMICAL PHARMACOLOGY
PMID：
34673013
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence
点击查看 >>
Author：
Wan Ruyan, Long Siqi, Ma Shuaichen, Yan Peishuo, Li Zhongzheng, Xu Kai, Lian Hui, Li Wenwen, Duan Yudi, Zhu Miaomiao, Wang Lan, Yu Guoying
IF：
5.8000
Publish_to：
RESPIRATORY RESEARCH
PMID：
38566093
Functional Analysis of the Phosphate Transporter Gene MtPT6 From Medicago truncatula
点击查看 >>
Author：
Cao Yuman, Liu Jinlong, Li Yuanying, Zhang Jing, Li Shuxia, An Yunru, Hu Tianming, Yang Peizhi
IF：
5.7540
Publish_to：
Frontiers in Plant Science
PMID：
33613589
Metformin ameliorates 5-fluorouracil-induced intestinal injury by inhibiting cellular senescence, inflammation, and oxidative stress
点击查看 >>
Author：
Jing Xia, Jun Chen, Manoj Kumar Vashisth, Yuchen Ge, Qianlong Dai, Siyue He, Yi-ling Shi, Xiao-bo Wang
IF：
5.7140
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
36327871
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
点击查看 >>
Author：
Wang Kaiqing, Gong Zhicheng, Chen Yanyan, Zhang Meimei, Wang Suzeng, Yao Surui, Liu Zhihui, Huang Zhaohui, Fei Bojian
IF：
5.7000
Publish_to：
Clinical Epigenetics
PMID：
37848946
LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis
点击查看 >>
Author：
Zhenkai Lou, Jinwen Zhu, Xing Li, Xingguo Li, Kaili Du, Bing Wang, Fan Zhang, Xinliang Zhang
IF：
5.6820
Publish_to：
Aging-US
PMID：
33638947
Peficitinib ameliorates doxorubicin-induced cardiotoxicity by suppressing cellular senescence and enhances its antitumor activity
点击查看 >>
Author：
Hui Hua, Qi Zhao, Jing Xia, Qian-long Dai, Shi-rui Bai, Xiao-bo Wang, Min Zhou
IF：
5.6000
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
37451017
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice
点击查看 >>
Author：
Yue Zhang, Jianhui Liu, Xiangyang Li, Guiqing Zhou, Yujian Sang, Mingyuan Zhang, Leqiang Gao, Jinglong Xue, Moxuan Zhao, Huanling Yu, Xianqing Zhou
IF：
5.5720
Publish_to：
FOOD AND CHEMICAL TOXICOLOGY
PMID：
36502996
GKT137831 in combination with adipose-derived stem cells alleviates high glucose-induced inflamm-aging and improves diabetic wound healing
点击查看 >>
Author：
Dong Yunxian, Zhang Youliang, Li Fangwei, Tang Bing, Lv Dongming, Wang Haibin, Luo Shengkang
IF：
5.5000
Publish_to：
JOURNAL OF LEUKOCYTE BIOLOGY
PMID：
37774495
Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy
点击查看 >>
Author：
Ning Jiang, Baizhou Xing, Rong Peng, Jie Shang, Biao Wu, Peilun Xiao, Shiyuan Lin, Xianghe Xu, Huading Lu
IF：
5.4980
Publish_to：
MECHANISMS OF AGEING AND DEVELOPMENT
PMID：
35728631
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway
点击查看 >>
Author：
Shuo Zhang, Rong Zhang, Pengyan Qiao, Xiaocao Ma, Rongjian Lu, Feifan Wang, Chuanjie Li, Lingling E, Hongchen Liu
IF：
5.4430
Publish_to：
Stem Cells International
PMID：
33505470
DNMT3A governs tyrosine kinase inhibitors responses through IAPs and in a cell senescence-dependent manner in non-small cell lung cancer
点击查看 >>
Author：
Qin-Fang Deng, Chao Li, Jing Liu, Xian-Xiu Ji, Xiao-Ying Wan, Chun-Yan Wang, Hui Sun, Qi-Yu Fang, Wei-Qin Gu, Chao Ma, Hui-Yong Wang, Cai-Cun Zhou, Yi-Xue Li, Bo-Xiong Xie, Song-Wen Zhou
IF：
5.3000
Publish_to：
American Journal of Cancer Research
PMID：
37693159
Hybrid Membrane-Derived Nanoparticles for Isoliquiritin Enhanced Glioma Therapy
点击查看 >>
Author：
Wenwan Shi, Xia Cao, Qi Liu, Qin Zhu, Kai Liu, Tianwen Deng, Qingtong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang, Ximing Xu
IF：
5.2150
Publish_to：
Pharmaceuticals
PMID：
36145280
Proteomic analysis reveals the aging-related pathways contribute to pulmonary fibrogenesis
点击查看 >>
Author：
Tingwei Zhang, Xinglong Yuan, Mengqi Jiang, Bo Liu, Nailiang Zhai, Qian Zhang, Xiaodong Song, Changjun Lv, Jinjin Zhang, Hongbo Li
IF：
5.2000
Publish_to：
Aging-US
PMID：
38147026
Dendrobium nobile Lindl. Polysaccharides protect fibroblasts against UVA-induced photoaging via JNK/c-Jun/MMPs pathway
点击查看 >>
Author：
Wei Li, Xingrui Mu, Xingqian Wu, Wenjie He, Ye Liu, Yiqiu Liu, Junyu Deng, Xuqiang Nie
IF：
5.1950
Publish_to：
JOURNAL OF ETHNOPHARMACOLOGY
PMID：
35973631
Anti-inflammatory and Tendon-Protective Effects of Adipose Stem Cell-Derived Exosomes with Concomitant Use of Glucocorticoids
点击查看 >>
Author：
Xuancheng Zhang, Ang Li, Kang Han, He Zhang, Xiaoqiao Huangfu, Jinghuan Huang, Jia Jiang, Jinzhong Zhao
IF：
5.1310
Publish_to：
Stem Cells International
PMID：
35646125
Investigation of the bactericidal mechanism of Penicilazaphilone C on Escherichia coli based on 4D label-free quantitative proteomic analysis
点击查看 >>
Author：
Huange Zhao, Rong Ji, Xiangru Zha, Zhen Xu, Yingying Lin, Songlin Zhou
IF：
5.1120
Publish_to：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
PMID：
36179970
Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux
点击查看 >>
Author：
Junlong Zhong, Bin Wang, Biao Wu, Jie Shang, Ning Jiang, Aiyong Cui, Yufeng Chen, Xianghe Xu, Huading Lu
IF：
5.0370
Publish_to：
LIFE SCIENCES
PMID：
33450259
Lysophosphatidylethanolamine improves diastolic dysfunction by alleviating mitochondrial injury in the aging heart
点击查看 >>
Author：
Guiwen Xu, Wei Xiao, Pengqi Sun, Yuanjun Sun, Xinyu Yang, Xiaomeng Yin, Yang Liu
IF：
5.0000
Publish_to：
JOURNAL OF LIPID RESEARCH
PMID：
39579983
Network Pharmacology Combined with Experimental Validation to Investigate the Effects and Mechanisms of Aucubin on Aging-Related Muscle Atrophy
点击查看 >>
Author：
Wenan Li, Kaishu Deng, Mengyue Zhang, Yan Xu, Jingxi Zhang, Qingsheng Liang, Zhiyou Yang, Leigang Jin, Chuanyin Hu, Yun-Tao Zhao
IF：
4.9000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
40141269
miR-155-5p/Bmal1 Modulates the Senescence and Osteogenic Differentiation of Mouse BMSCs through the Hippo Signaling Pathway
点击查看 >>
Author：
Zhang Lanxin, Zhang Chengxiaoxue, Zheng Jiawen, Wang Yuhong, Wei Xiaoyu, Yang Yuqing, Zhao Qing
IF：
4.8000
Publish_to：
Stem Cell Reviews and Reports
PMID：
38150082
TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation
点击查看 >>
Author：
Zhu Jiaojiao, Ao Xingkun, Liu Yuhao, Zhou Shenghui, Hou Yifan, Yan Ziyan, Zhou Lin, Chen Huixi, Wang Ping, Liang Xinxin, Xie Dafei, Gao Shanshan, Zhou Ping-Kun, Gu Yongqing
IF：
4.7000
Publish_to：
RESPIRATORY RESEARCH
PMID：
39113018
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis
点击查看 >>
Author：
Tan Jiajia, Wei Jing, Lu Hongxiang
IF：
4.6570
Publish_to：
INFLAMMATION
PMID：
37036563
Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy
点击查看 >>
Author：
Jie Shang, Nan Lin, Rong Peng, Ning Jiang, Biao Wu, Baizhou Xing, Shiyuan Lin, Xianghe Xu, Huading Lu
IF：
4.6000
Publish_to：
MOLECULES
PMID：
36770589
Improving porcine SCNT efficiency by selecting donor cells size
点击查看 >>
Author：
Deling Jiao, Wenmin Cheng, Xiaolin Zhang, Yifan Zhang, Jianxiong Guo, Zhuo Li, Dejia Shi, Zhe Xiong, Yubo Qing, Muhammad Ameen Jamal, Kaixiang Xu, Hong-Ye Zhao, Hong-Jiang Wei
IF：
4.5340
Publish_to：
CELL CYCLE
PMID：
34583621
Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice
点击查看 >>
Author：
Xiaoli Guo, Cheng Cheng, Lin Wang, Dongbei Li, Ruihua Fan, Xudong Wei
IF：
4.5000
Publish_to：
ENVIRONMENTAL TOXICOLOGY
PMID：
37466197
Anti-aging and anti-oxidant activities of murine short interspersed nuclear element antisense RNA
点击查看 >>
Author：
Zhixue Song, Suleman Shah, Baixue Lv, Ning Ji, Xin Liu, Lifang Yan, Murad Khan, Yufang Zhao, Peiyuan Wu, Shufeng Liu, Long Zheng, Libo Su, Xiufang Wang, Zhanjun Lv
IF：
4.4320
Publish_to：
EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：
34688636
Hsa_circRNA_0000284 acts as a ceRNA to participate in coronary heart disease progression by sponging miRNA-338-3p via regulating the expression of ETS1
点击查看 >>
Author：
PhongSon Dinh, ChauMyThanh Tran, ThiPhuongHoai Dinh, Awais Ali, ShangLing Pan
IF：
4.4000
Publish_to：
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
PMID：
37334706
Extracellular vesicles derived from HuMSCs alleviate daunorubicin-induced cardiac microvascular injury via miR-186-5p/PARP9/STAT1 signal pathway
点击查看 >>
Author：
Shule Zhang, Dong Li, Linghong Liu, Qing Shi, Xiuli Ju
IF：
4.3000
Publish_to：
Regenerative Therapy
PMID：
38327716
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway
点击查看 >>
Author：
Li Na, Luo Runan, Zhang Wenlong, Wu Yu, Hu Chaojie, Liu Manli, Jiang Diya, Jiang Ziran, Zhao Xinxin, Wang Yiping, Li Qing
IF：
4.2840
Publish_to：
BIOGERONTOLOGY
PMID：
36463389
Network Pharmacology and Machine Learning Reveal Salidroside’s Mechanisms in Idiopathic Pulmonary Fibrosis Treatment
点击查看 >>
Author：
Chenchun Ding, Zhenzhen Guo, Quan Liao, Renjie Zuo, Junjie He, Ziwei Ye, Weibin Chen
IF：
4.2000
Publish_to：
Journal of Inflammation Research
PMID：
39600682
Adipose Tissue–derived Microvascular Fragments as Vascularization Units for Dental Pulp Regeneration
点击查看 >>
Author：
Xun Xu, Cheng Liang, Xin Gao, Haisen Huang, Xiaotao Xing, Qi Tang, Jian Yang, Yutao Wu, Maojiao Li, Huanian Li, Li Liao, Weidong Tian
IF：
4.1710
Publish_to：
JOURNAL OF ENDODONTICS
PMID：
33887305
Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells
点击查看 >>
Author：
Hang Li, Xiao-Qing Ji, Shu-Ming Zhang, Ri-Hui Bi
IF：
4.1000
Publish_to：
World Journal of Stem Cells
PMID：
38058960
Cmpk2 regulates mitochondrial function in glucocorticoid-induced osteoblast senescence and affects glucocorticoid-inhibited osteoblast differentiation
点击查看 >>
Author：
Nianping Cao, Zhihang Wang, Chongjun Huang, Bobo Chen, Pengyu Zhao, Ying Xu, Ye Tian
IF：
4.0000
Publish_to：
ARCHIVES OF GERONTOLOGY AND GERIATRICS
PMID：
37269696
Phoenixin-14 Ameliorates Cellular Senescence Against Morphine in M17 Neuronal Cells
点击查看 >>
Author：
Hu Yonghe, Shen Xinxin, Liu Feifan, Zhu Weiguo
IF：
3.9780
Publish_to：
NEUROTOXICITY RESEARCH
PMID：
35298792
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease
点击查看 >>
Author：
Dan Wang, Ling Yin, Rongyu Chen, Wanlin Tan, Luqun Liang, Jiayi Xiang, Huifang Zhang, Xingcheng Zhou, Huaqing Deng, Bing Guo, Yuanyuan Wang
IF：
3.9000
Publish_to：
Frontiers in Medicine
PMID：
36760880
Abnormal mechanical stress induced chondrocyte senescence by YAP loss-mediated METTL3 upregulation
点击查看 >>
Author：
Fan Yang, Peiqi Wang, Xiaomeng Dong, Wenyu Dai, Wanxi Chen, Gang Yuan, Ding Bai, Hui Xu
IF：
3.8000
Publish_to：
ORAL DISEASES
PMID：
37983852
Selection of a galactose-positive mutant strain of Streptococcus thermophilus and its optimized production as a high-vitality starter culture
点击查看 >>
Author：
Haimin Hu, gesudu Qimu, Jiaying Nie, Na Wu, Tong Dan
IF：
3.7000
Publish_to：
JOURNAL OF DAIRY SCIENCE
PMID：
38754828
Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathways
点击查看 >>
Author：
Huaping Zhang, Xuefen Pang, Haixia Yu, Hui Zhou
IF：
3.6520
Publish_to：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
PMID：
34719845
Q-switched 1064 nm Nd: YAG laser restores skin photoageing by activating autophagy by TGFβ1 and ITGB1
点击查看 >>
Author：
Huiyi Xiang, Xiaorong Jia, Xiaoxia Duan, Qi Xu, Ruiqi Zhang, Yunting He, Zhi Yang
IF：
3.6000
Publish_to：
EXPERIMENTAL DERMATOLOGY
PMID：
38284200
Genistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis
点击查看 >>
Author：
Guihua Wu, Siming Li, Guangjin Qu, Jiajia Hua, Jing Zong, Xiaofeng Li, Fanghui Xu
IF：
3.5030
Publish_to：
PHARMACEUTICAL BIOLOGY
PMID：
34663173
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice
点击查看 >>
Author：
Zhenyu Feng, Yang Liu, Yijin Yang, Jie Bai, Qiu-yue Lin, Yun-long Xia, Yunpeng Xie
IF：
3.4000
Publish_to：
Heliyon
PMID：
39347399
Trifluridine induces HUVECs senescence by inhibiting mTOR-dependent autophagy
点击查看 >>
Author：
Hui-Jie Jia, Min Zhou, Manoj Kumar Vashisth, Jing Xia, Hui Hua, Qian-long Dai, Shi-Rui Bai, Qi Zhao, Xiao-bo Wang, Yi-ling Shi
IF：
3.3220
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
35462092
Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway
点击查看 >>
Author：
Li Min-yan, Qin Yan-qin, Tian Yan-ge, Li Kang-chen, Oliver Brian G., Liu Xue-fang, Zhao Peng, Li Jian-sheng
IF：
3.3200
Publish_to：
BMC Pulmonary Medicine
PMID：
36414945
The transcriptional regulator EtrA mediates ompW contributing to the pathogenicity of avian pathogenic Escherichia coli
点击查看 >>
Author：
Dandan Fu, Qianqian Zheng, Xiaoyan Wu, Jianmei Wu, Ying Shao, Zhenyu Wang, Jian Tu, Xiangjun Song, Kezong Qi
IF：
3.3000
Publish_to：
VETERINARY MICROBIOLOGY
PMID：
37210862
A combination of pirfenidone and TGF-β inhibition mitigates cystic echinococcosis-associated hepatic injury
点击查看 >>
Author：
Erqiang Wang, Zhenyu Liao, Lianghai Wang, Yuan Liao, Xiaodan Xu, Ping Liu, Xian Wang, Jun Hou, Huijiao Jiang, Xiangwei Wu, Xueling Chen
IF：
3.2340
Publish_to：
PARASITOLOGY
PMID：
33583470
Sesamol Alleviated Lipotoxicity-Induced Dysfunction in MIN6 Cells via Facilitating Cellular Senescence Caused by Endoplasmic Reticulum Stress
点击查看 >>
Author：
Yan Xie, Yongyan Tang, Jinxin Yang, Mahnoor Atta, Nan Wang, Hong Qin
IF：
3.2000
Publish_to：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
PMID：
39470143
Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation
点击查看 >>
Author：
Huang Zuocai, Gu Zhonghang, Zeng Yuanjuan, Zhang Dongxing
IF：
3.1000
Publish_to：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
PMID：
39836253
Long noncoding RNA Gm31629 promotes bone regeneration by maintaining bone marrow mesenchymal stem cells activity
点击查看 >>
Author：
Guangping Cai, Ye Xiao, Mi Yang, Qi Guo, Tian Su, Yalin Liu, Tiejian Jiang, Chun Li
IF：
3.0610
Publish_to：
PeerJ
PMID：
35702257
High glucose levels delay the senescence of stem cells from human exfoliated deciduous teeth by suppressing autophagy
点击查看 >>
Author：
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
IF：
3.0000
Publish_to：
ARCHIVES OF ORAL BIOLOGY
PMID：
37992563
UBE2E3 regulates cellular senescence and osteogenic differentiation of BMSCs during aging
点击查看 >>
Author：
Yalin Liu, Guangping Cai, Peng Chen, Tiejian Jiang, Zhuying Xia
IF：
2.9840
Publish_to：
PeerJ
PMID：
34820159
Extrinsic apoptosis and senescence involved in growth kinetics of seminoma to cisplatin
点击查看 >>
Author：
Yinghao Yin, Jingxuan Peng, Xiaoping Zheng, Jun Zhou, Yong Wang, Yingbo Dai, Guangming Yin, Yuxin Tang
IF：
2.9630
Publish_to：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
PMID：
36222180
H3K14 hyperacetylation‑mediated c‑Myc binding to the miR‑30a‑5p gene promoter under hypoxia postconditioning protects senescent cardiomyocytes from hypoxia/reoxygenation injury
点击查看 >>
Author：
Lingbo Xu, Huiping Zhang, Yanhua Wang, Wei Guo, Lingyu Gu, Anning Yang, Shengchao Ma, Yong Yang, Kai Wu, Yideng Jiang
IF：
2.9520
Publish_to：
Molecular Medicine Reports
PMID：
33880587
Age-related endoplasmic reticulum stress represses testosterone synthesis via attenuation of the circadian clock in Leydig cells
点击查看 >>
Author：
Lei Gao, Dengke Gao, Jing Zhang, Cuimei Li, Meina Wu, Yaoyao Xiao, Luda Yang, Tiantian Ma, Xiaoyu Wang, Manhui Zhang, Dan Yang, Tao Pan, Haisen Zhang, Aihua Wang, Yaping Jin, Huatao Chen
IF：
2.9230
Publish_to：
THERIOGENOLOGY
PMID：
35753227
Chemoproteomics Reveals That Quaternary Protoberberine Alkaloids Inhibit Telomerase Activity Oncologically by Binding to PES1
点击查看 >>
Author：
Ling-Wen Xu, Xue-Qian Zhang, Zheng Yan, Zhi-Hong Li, An-Jun Deng, Hai-Lin Qin
IF：
2.9000
Publish_to：
CHEMISTRY & BIODIVERSITY
PMID：
36951446
Cochlear metabolomics, highlighting novel insights of purine metabolic alterations in age-related hearing loss
点击查看 >>
Author：
Huanzhi Wan, Wenjing Wang, Jingchun Liu, Yunlong Zhang, Bingqian Yang, Rongkai Hua, Huidong Chen, Shiming Chen, Qingquan Hua
IF：
2.8000
Publish_to：
HEARING RESEARCH
PMID：
37939412
Astragalus polysaccharide alleviated hepatocyte senescence via autophagy pathway
点击查看 >>
Author：
Ting Yao, Jin-Mei Chen, Le-Er Shen, Yong-Sheng Yu, Zheng-Hao Tang, Guo-Qing Zang, Yi Zhang, Xiao-Hua Chen
IF：
2.7440
Publish_to：
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
PMID：
34962345
GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs
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Author：
Yanna Wang, Changyuan Wang, Ying Gong, Qingchen Li, Mozhen Liu, Huijun Sun
IF：
2.7000
Publish_to：
TISSUE & CELL
PMID：
39954559
Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts
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Author：
Fei Song, Lihua Wang, Jing Mu, Huisheng Ma
IF：
2.6500
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
35800012
The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of High-grade Serous Ovarian Cancer Through Acetylation of p53
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Author：
Ye Cong, Cheng Yan, Qian Xiaohong, Zhong Bo, Ma Jinchun, Guo Hongling
IF：
2.4000
Publish_to：
BIOCHEMICAL GENETICS
PMID：
38388849
ANXA2 promotes osteogenic differentiation and inhibits cellular senescence of periodontal ligament cells (PDLCs) in high glucose conditions
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Author：
Yanlin Huang, Jiaye Wang, Chunhui Jiang, Minghe Zheng, Mingfang Han, Qian Fang, Yizhao Liu, Ru Li, Liangjun Zhong, Zehui Li
IF：
2.3000
Publish_to：
PeerJ
PMID：
39308808
Handelin Reduces Ultraviolet A-Induced Photoaging by Inhibiting Reactive Oxygen Species Generation and Enhancing Autophagy
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Author：
Yi Duan, Yang Xiang, Jimin Chu, Xianghong Lin, Miao He, Chenggui Zhang, Sujiao Sun, Ling Huang
IF：
2.2000
Publish_to：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
PMID：
36476587
Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption
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Author：
Qi Lu, Lin-feng Zou, Yuan-zhen Gao, Ting Ye, Meng-jiao Li, Yu-Kun Zhang, Bing Liang, Wenshe Sun, Dong-ming Xing
IF：
2.1890
Publish_to：
Journal of Cosmetic Dermatology
PMID：
36575875
Assessment of cellular senescence potential of PM2.5 using 3D human lung fibroblast spheroids in vitro model
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Author：
Xu Shengmin, Ma Lin, Wu Tao, Tian Yushan, Wu Lijun
IF：
2.1000
Publish_to：
Toxicology Research
PMID：
38500513
Effects of blood components of preoperative autologous blood donation on functions of myelopoietic stem cells
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Author：
Yu Bai, Yongjun Su, Jinhuo Wang, Na Yao, Lishuang Duan, Tong Liu, Jianrong Guo
IF：
1.9000
Publish_to：
Hematology
PMID：
37545417
技术问答
（52）
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请问这个染色和细胞的密度有关吗，我的细胞密度特别低的情况下染不上，而且感觉染色结果不稳定，在试剂盒刚到的时候特别好用但是后面就染不出来这种效果了2025-04-18 17:39:01
您好，有一定关系，细胞密度高容易出现接触抑制更容易导致衰老，细胞密度低营养充足会不容易发生衰老。您说的效果差异使用的是同一种细胞和同样密度吗，具体情况可以联系400-968-6088转2进行具体问题反馈，我们会有技术支持同事与您对接。
请问可以衰老染色完成再去染DAPI或者死亡PI染色吗？另外，如果一个刺激会诱导细胞死亡，那染色会不会显示比对照组低，但是细胞都是死的2025-01-14 10:50:01
您好，一般不建议继续染DAPI或PI，因为前面经过了固定和染色处理步骤，细胞的通透性发生了改变，再染DAPI或PI不能反映原始活死状况，建议做平行实验。如果药物刺激性较强导致细胞大量死亡，贴壁细胞会大量减少，从而染色结果可能会出现实验组较对照组阳性率低的情况。
固定液是否可以用百分之四多聚甲醛而不是试剂盒提供的固定液2024-12-30 18:36:11
您好，可以，但固定时间不宜过长，且固定后应及时进行后续染色。
需要调PH值碱化溶酶体吗？怎么确定染色是特意的衰老的而不是非衰老的β-gal酶活性2024-12-13 13:49:32
您好，无需调节pH，在特定pH下，在β-Gal的作用下，X-Gal被水解产生蓝色产物。因此，含有活性β-Gal的细胞可以通过蓝色着色直观地被检测出来。正常增殖的细胞或早期癌细胞通常不表现出这种蓝色着色，而衰老细胞则会显示出明显的蓝色着色。
请问可以染色酵母菌么？2024-12-12 09:12:17
您好，多数酵母菌不表达或仅微量表达 β- 半乳糖苷酶，您可以自行设计预实验进行测试。