英文名称 |
Anti-ErbB2 Monoclonal Antibody |
中文名称 |
HER2受体抗体 |
宿主 |
Mouse |
克隆类型 |
Monoclonal Antibody |
亚型 |
IgG1 |
稀释比例 |
WB 1:500-1000. IHC 1:50-100. IF 1:50-200. ICC 1:50-200. |
靶标 |
ErbB2 |
别名 |
CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 |
背景说明 |
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. |
Swiss Prot |
P04626 |
Gene ID |
2064 |
亚细胞定位 |
Cell membrane Cytoplasm Membrane, Nucleus |
免疫原 |
A synthetic peptide of human HER2 |
理论分子量 |
63/71/97/135/137/138kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 0.02% sodium azide,0.5% BSA,50% glycerol,pH7.3. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles. |
规格 |
50ul 100ul |
交叉反应 |
Human Mouse Rat |
应用 |
WB IHC IF ICC |
研究领域 |
肿瘤&癌症 发育生物学 细胞生物学 信号传导 表观遗传 |
单位 |
支 |
属性分类 |
其他抗体 |