英文名称 |
Anti-CEP95 Polyclonal Antibody |
中文名称 |
卷曲螺旋结构域蛋白45抗体 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
稀释比例 |
WB 1:1000-3000. IHC 1:50-200. |
靶标 |
CEP95 |
别名 |
CCDC45, Centrosomal protein 95kDa, Centrosomal protein of 95 kDa, Cep95, CEP95_HUMAN, Coiled coil domain containing 45, Coiled-coil domain-containing protein 45 |
背景说明 |
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC45 (coiled-coil domain containing 45) is a 821 amino acid protein encoded by a gene that maps to human chromosome 17q23.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. |
Swiss Prot |
Q96GE4 |
Gene ID |
90799 |
亚细胞定位 |
Cytoplasm |
免疫原 |
A synthetic peptide of human CEP95 |
Public Immunogen Range |
125-175/821aa |
理论分子量 |
77/95kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
储存条件 |
Store at -20℃. Avoid freeze/thaw cycles. |
规格 |
20ul 50ul 100ul |
交叉反应 |
Human |
应用 |
WB IHC |
研究领域 |
肿瘤&癌症 细胞生物学 表观遗传 |
单位 |
支 |
属性分类 |
其他抗体 |