英文名称 |
Anti-TOP2A Polyclonal Antibody |
中文名称 |
DNA拓普西异构酶Ⅱ抗体 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
预测交叉反应 |
Chicken(87.5%);Pig(100%);Hamster(100%);Silkworm(100%);Candida albicans(85.7%);Arabidopsis thaliana(92.9%);Caenorhabditis elegans(93.3%) |
稀释比例 |
WB 1:2000-5000. IHC 1:25-100. ELISA 1:2000-20000. |
靶标 |
TOP2A |
别名 |
DNA topoisomeraseⅡalpha, TOPO II, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2, TP2A, DNA topoisomerase II 170 kD, DNA topoisomerase II alpha isozyme, DNA Topoisomerase2, TOP 2A, TopII alpha, Topo II alpha, Topoisomerase DNA II alpha 170kDa, Topoisomerase II alpha 170 kDa, TOP2A_HUMAN, Topo IIα, Topo-IIα, Topoisomerase II-α. |
背景说明 |
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
Swiss Prot |
P11388 |
Gene ID |
7153 |
免疫原 |
A synthetic peptide of human TOP2A |
Public Immunogen Range |
65-115/1531aa |
理论分子量 |
174/177/182kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
储存条件 |
Store at -20℃. Avoid freeze/thaw cycles. |
规格 |
20ul 50ul 100ul |
交叉反应 |
Human Rat Mouse |
应用 |
WB IHC ELISA |
研究领域 |
肿瘤&癌症 新陈代谢 表观遗传 |
单位 |
支 |
属性分类 |
其他抗体 |