英文名称 |
Anti-CYFIP2 Polyclonal Antibody |
中文名称 |
细胞质FMR1相互作用蛋白2抗体 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
稀释比例 |
WB 1:500-2000. IHC 1:20-200. |
靶标 |
CYFIP2 |
别名 |
CYFP2, cytoplasmic FMR1 interacting protein 2, KIAA1168, p53 inducible protein, p53-inducible protein 121, PIR121, CYFP2_HUMAN |
背景说明 |
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation. |
Swiss Prot |
Q96F07 |
Gene ID |
26999 |
亚细胞定位 |
Cytoplasm |
免疫原 |
Recombinant protein of human CYFIP2 |
Public Immunogen Range |
1029-1278aa |
理论分子量 |
148kDa |
纯化方法 |
Affinity purification |
储存液 |
pH7.4 PBS,0.05% NaN3,40% Glycerol. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles. |
规格 |
50ul 100ul |
交叉反应 |
Human Mouse |
应用 |
WB IHC |
研究领域 |
神经学 细胞生物学 发育生物学 信号传导 |
单位 |
支 |
属性分类 |
其他抗体 |