英文名称 |
Anti-NUP98 Monoclonal Antibody |
宿主 |
Mouse |
克隆类型 |
Monoclonal Antibody |
亚型 |
IgG1 |
克隆号 |
3B8-D7-H10 |
稀释比例 |
WB 1:500-1000. IP 1:20. |
靶标 |
NUP98 |
别名 |
96 kDa nucleoporin, 98 kDa nucleoporin, ADAR2, ADIR2, GLFG-repeat containing nucleoporin, Nuclear pore complex protein Nup96, Nuclear pore complex protein Nup98 Nup96, Nucleoporin 98kD, nucleoporin 98kDa, Nucleoporin Nup96, Nucleoporin Nup98, NUP196, NUP96, Nup98, Nup98-Nup96, NUP98_HUMAN |
背景说明 |
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Swiss Prot |
P52948 |
Gene ID |
4928 |
亚细胞定位 |
Nucleoplasmic side Nucleus Nucleus membrane Peripheral membrane protein nuclear pore complex |
免疫原 |
Recombinant protein of human NUP98 |
理论分子量 |
198/187/98kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 0.02% sodium azide,0.5% BSA,50% glycerol,pH7.3. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles. |
规格 |
50ul 100ul |
交叉反应 |
Human |
应用 |
WB IP |
单位 |
支 |
属性分类 |
其他抗体 |