英文名称 |
Anti-CDK4 Monoclonal Antibody |
中文名称 |
周期蛋白-依赖性蛋白激酶4抗体 |
宿主 |
Mouse |
克隆类型 |
Monoclonal Antibody |
亚型 |
IgG1 |
克隆号 |
3F9-B12-C8 |
稀释比例 |
WB 1:500-1000. |
靶标 |
CDK4 |
别名 |
Cdk 4,CDK4 protein,Cell division kinase 4,Cell division protein kinase 4,CMM 3,CMM3,Crk3,Cyclin dependent kinase 4,Melanoma cutaneous malignant 3,MGC14458,p34 cdk4,PSK J3,CDK4_HUMAN |
背景说明 |
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. |
Swiss Prot |
P11802 |
Gene ID |
1019 |
亚细胞定位 |
Cytoplasm Membrane Nucleus |
免疫原 |
Recombinant protein of human CDK4 |
理论分子量 |
33kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 0.02% sodium azide,0.5% BSA,50% glycerol,pH7.3. |
储存条件 |
Store at -20℃. Avoid freeze / thaw cycles. |
规格 |
50ul 100ul |
交叉反应 |
Human Rat Mouse |
应用 |
WB |
研究领域 |
细胞生物学 信号传导 表观遗传 |
单位 |
支 |
属性分类 |
其他抗体 |