英文名称 |
Anti-E-cadherin Polyclonal Antibody |
中文名称 |
上皮钙粘附分子抗体 |
宿主 |
Rabbit |
克隆类型 |
Polyclonal Antibody |
亚型 |
IgG |
稀释比例 |
WB 1:20000-200000. IHC 1:5000-20000. IF 1:50-800. IP 0.5-4.0ug. |
靶标 |
E-cadherin |
别名 |
E-cadherin; anion exchanger protein 3; Arc 1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 234; CD324; CD324 antigen; CDH1; CDHE; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin; CADH1_HUMAN |
背景说明 |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
Swiss Prot |
P12830 |
Gene ID |
999 |
亚细胞定位 |
Cell junction,Cell membrane,Endosome,Golgi apparatus,Single-pass type I membrane protein,trans-Golgi network |
免疫原 |
Recombinant protein of human E-cadherin |
Public Immunogen Range |
373-622aa |
理论分子量 |
97kDa |
实际分子量 |
120-125kDa |
纯化方法 |
Affinity purification |
储存液 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
储存条件 |
Store at -20℃.Avoid freeze/thaw cycles. |
运输条件 |
冷冻运输 |
规格 |
50ul 100ul |
交叉反应 |
Human Mouse Rat |
应用 |
WB ELISA IHC IF IP |
研究领域 |
肿瘤&癌症 细胞生物学 神经学 信号传导 |
单位 |
支 |
属性分类 |
其他抗体 |