中文
英语
产品简介
| 中文名称 | 尼氏染色试剂盒(亚甲蓝法) |
| 英文名称 | Nissl Stain Kit(Methylene Blue Method) |
| 储存条件 | RT，避光保存，有效期6个月。 |
| 货期 | 2-3天 |
| 规格 | 3*50ml |
| 单位 | 盒 |
尼氏体(Nissl body)或称尼氏小体是分布于神经细胞胞质内的三角形或椭圆形小块状物质，能被碱性染料如硫堇、亚甲蓝、甲苯胺蓝和焦油紫等染料染成紫蓝色。
尼氏染色液(Nissl Stain，亚甲蓝法)主要优点是操作简便、染色稳定、适用范围广，可以用于石蜡组织切片的尼氏物质、神经元等的染色，尼氏体的存在和消失是神经细胞是否受损的重要指标，当发生脑炎、脑缺血、轴突反应等情况时，尼氏体会发生溶解甚至消失。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
实验图
小鼠脑石蜡切片
尼氏体着蓝色，背景着浅蓝色或接近于无色
尼氏体着蓝色，背景着浅蓝色或接近于无色
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Publish_to：
JOURNAL OF BIOLOGICAL CHEMISTRY
PMID：
39730060
The neuroprotective role of morroniside against spinal cord injury in female rats
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Author：
Fei-Xiang Duan, Yu-Jiao Shi, Jing Chen, Xue Song, Lin Shen, Qi Qi, Shu-Qin Ding, Qi-Yi Wang, Rui Wang, He-Zuo Lü, Jian-Guo Hu
IF：
3.9210
Publish_to：
NEUROCHEMISTRY INTERNATIONAL
PMID：
34147513
Sevoflurane Postconditioning Ameliorates Neuronal Migration Disorder Through Reelin/Dab1 and Improves Long-term Cognition in Neonatal Rats After Hypoxic-Ischemic Injury
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Author：
Zhang Yahan, Gao Qiushi, Wu Ziyi, Xue Hang, Zhao Ping
IF：
3.9110
Publish_to：
NEUROTOXICITY RESEARCH
PMID：
34224102
Up-regulating microRNA-214-3p relieves hypoxic–ischemic brain damage through inhibiting TXNIP expression
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Author：
Zhang Miaoyu, Zhou Haiyang, He Rongni, Yang Juan, Zou Yang, Deng Yiting, Xie Huifang, Yan Zhenxing
IF：
3.8420
Publish_to：
MOLECULAR AND CELLULAR BIOCHEMISTRY
PMID：
35980563
Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1
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Author：
Zhijuan Cheng, Jianglong Tu, Kai Wang, Fang Li, Yuan He, Wei Wu
IF：
3.8000
Publish_to：
BRAIN RESEARCH BULLETIN
PMID：
38253131
Antibacterial Effect of Chrysanthemum Buds' Crude Extract Against Salmonella Typhimurium and Potential Application in Cooked Chicken
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Author：
Min Xing, Jiyun Yao, Yiming Guo, Ru Xin, Yaping Yu, Encong Shi, Mengdi Hao, Peng Fei, Huaibin Kang, Junliang Chen
IF：
3.7880
Publish_to：
Foodborne Pathogens and Disease
PMID：
35363059
MicroRNA-27a-3p relieves inflammation and neurologic impairment after cerebral ischaemia reperfusion via inhibiting lipopolysaccharide induced TNF factor and the TLR4/NF-κB pathway
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Author：
Jing Luo, Junjie Li, Li Xiong, Linna Fan, Lijia Peng, Yuan Yang, Di Lu, Jianlin Shao
IF：
3.6980
Publish_to：
EUROPEAN JOURNAL OF NEUROSCIENCE
PMID：
35584745
Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice
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Author：
Huaxiang Shi, Pengfei Li, Hu Zhou, Zhiyong Nie, Jingxin Zhang, Xin Sui, Jiabin Guo, Yongan Wang, Liyun Wang
IF：
3.6100
Publish_to：
BRAIN RESEARCH
PMID：
35724762
Polysaccharide alleviates neurodegeneration and behavioral deficit by enhancing mitochondrial autophagy in chronic methamphetamine mice
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Author：
Han Yang, Yuanhe Wang, Shan Liu, Shan Zhang, Yuemeng Chen, Jiuyang Ding, Shunqin Chen, Faze Zhu, Bing Xia, Peng Luo, Yubo Liu
IF：
3.4000
Publish_to：
NEUROTOXICOLOGY
PMID：
39954861
Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats
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Author：
Jian Zhao, Ailang Pang, Saige Yin, Meifeng Yang, Xuemei Zhang, Rong Zhang, Jingfei Liu, Yuanqi Gu, Shanshan Li, Yan Hu, Yue Zhang, Yingchun Ba, Buliang Meng, Xinwang Yang
IF：
3.3220
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
35158211
GABAB Receptor Activation Attenuates Neuronal Pyroptosis in Post-cardiac Arrest Brain Injury
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Author：
Ye Sun, Jinying Li, Haikuo Wu, Ziwei Zhao, Ting Cong, Liya Li, Xiaonan Zhang, Shengming Yin, Zhaoyang Xiao
IF：
3.3000
Publish_to：
NEUROSCIENCE
PMID：
37352966
Bone mesenchymal stem cell-derived extracellular vesicles deliver microRNA-23b to alleviate spinal cord injury by targeting toll-like receptor TLR4 and inhibiting NF-κB pathway activation
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Author：
Hongfei Nie, Zhensong Jiang
IF：
3.2690
Publish_to：
Bioengineered
PMID：
34663169
Annao Pingchong decoction attenuates oxidative stress and neuronal apoptosis following intracerebral hemorrhage via RAGE-NOX2/4 axis
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Author：
Xu Wang, Xiaoyuan Lin, Zilin Chen, Hongping Long, Xuqing Zhou, Shihui Lei, Jian Liu, Huan Dong, Fang Liu, Hua Hu, Chun Guo
IF：
3.2000
Publish_to：
Frontiers in Neuroscience
PMID：
39737434
Berberine Ameliorates Lipopolysaccharide-Induced Cognitive Impairment Through SIRT1/NRF2/NF-κB Signaling Pathway in C57BL/6J Mice
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Author：
Nan Chen, Xin-Chen Wang, Ling-Ling Fan, Yu-Huang Zhu, Qi Wang, Yun-Bo Chen
IF：
3.1920
Publish_to：
REJUVENATION RESEARCH
PMID：
36029207
The effects of noise exposure on hippocampal cognition in C57BL/6 mice via transcriptomics
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Author：
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
IF：
3.1000
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
38016245
Ozone rectal insufflation mitigates chronic rapid eye movement sleep deprivation-induced cognitive impairment through inflammation alleviation and gut microbiota regulation in mice
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Author：
Cheng Jie, Williams John P., Zhou Li, Wang Peng-Cheng, Sun Li-Na, Li Rui-Hua, An Jian-Xiong
IF：
3.0000
Publish_to：
Medical Gas Research
PMID：
39073330
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation
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Author：
Qiaoyu Li, Chongyang Zhang, Xiao Sun, Mengchen Wang, Zhixiu Zhang, Rongchang Chen, Xiaobo Sun
IF：
2.9000
Publish_to：
PLoS One
PMID：
38885233
Glyphosate Induces Anxiety-Like Behaviors in Mice via Activating NLRP3-Mediated Hippocampal Microglia Pyroptosis
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Author：
Shuge Shu, Xinting Chen, Jiawen Ren, Xiangyu Yu, Hao Zhang, Yongquan Yu
IF：
2.7000
Publish_to：
JOURNAL OF APPLIED TOXICOLOGY
PMID：
40254291
Dexmedetomidine (Dex) exerts protective effects on rat neuronal cells injured by cerebral ischemia/reperfusion via regulating the Sphk1/S1P signaling pathway
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Author：
Dawei Cong, Yunlong Yu, Yan Meng, Xia Qi
IF：
2.6770
Publish_to：
Journal of Stroke & Cerebrovascular Diseases
PMID：
36395661
Sevoflurane preconditioning improves neuroinflammation in cerebral ischemia/reperfusion induced rats through ROS-NLRP3 pathway
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Author：
Shujun Shang, Fengqiang Sun, Yulin Zhu, Jingui Yu, Lingzhi Yu, Wei Shao, Zhijuan Wang, Xuecai Yi
IF：
2.5000
Publish_to：
NEUROSCIENCE LETTERS
PMID：
36868396
Oscillating field stimulation promotes recovery from spinal cord injury in rats by regulating the differentiation of endogenous neural stem cells
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Author：
Chao Fang, Jian Sun, Laifu Wei, Fei Gao, Jun Qian
IF：
2.4470
Publish_to：
Experimental and Therapeutic Medicine
PMID：
34345261
Electroacupuncture Relieves Hippocampal Injury by Heme Oxygenase-1 to Improve Mitochondrial Function
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Author：
Rui Mu, Na Li, Jian-bo Yu, Li-rong Gong, Shu-an Dong, Jia Shi, Yuan Zhang, Zi-lei Xie
IF：
2.4170
Publish_to：
JOURNAL OF SURGICAL RESEARCH
PMID：
35016152
LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats
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Author：
Youzhi Ning, Yue Zhang, Tao Jiang, Jianguo Feng, Jian Zhan, Cehua Ou, Lu Wang
IF：
2.4000
Publish_to：
NEUROSCIENCE RESEARCH
PMID：
39674403
Protocatechuic Acid improves Alzheimer's disease by regulating the cholinergic synaptic signaling pathway
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Author：
Siwen Li, Hongyan Zhu, Songtao Li, Rasmané SEMDE, Hongbo Teng, Mengqi Shi, Liang Huang, Xinru Lou, Beining Jia, Yan Zhao
IF：
2.3000
Publish_to：
CHEMISTRY & BIODIVERSITY
PMID：
39776239
PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway
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Author：
Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu
IF：
2.2000
Publish_to：
Biomolecules and Biomedicine
PMID：
39601768
Lipid nanoparticle-encapsulated lncRNA DLX6-AS1 knockdown ameliorates cerebral ischemic injury via the Nrf2/HO-1/NLRP3 axis
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Author：
Chang Song, Yan Li, Huiying Han, Yueyue Zhang, Ning Wang
IF：
1.7000
Publish_to：
NEUROLOGICAL RESEARCH
PMID：
38735062
Ferulic acid improves motor function induced by spinal cord injury in rats via inhibiting neuroinflammation and apoptosis
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Author：
Jiang Xi, Yu Xuefeng, Chen Jin, Jing Changfeng, Xu Lexing, Chen Ziwei, Liu Fuhe, Chen Lei
IF：
1.3880
Publish_to：
Acta Cirurgica Brasileira
PMID：
34495140
技术问答
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使用索莱宝尼氏染色试剂盒（G1434）时，染完以后脱水，当放入80%酒精脱水时蓝色全部没了，换了其他的80%酒精也是全部掉完颜色。请问出现这种掉色的原因（试剂盒在有效期内）2024-09-17 17:28:45
您好，脱水建议从无水乙醇开始
这个可以染神经元细胞吗?2023-10-12 23:04:32
您好，该试剂能染色神经元细胞，但是体外培养神经元通常不会像体内神经元一样存在高度活跃的蛋白合成活动，建议染色后以核形态而不是尼氏体多少进行神经元细胞辨别。
操作步骤有视频吗?2023-07-24 19:15:39
您好，暂无视频，如对操作步骤有不明白的地方可拨打400-968-6088转2与我司技术支持联系。