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Hoechst 33258
CAS:No.23491-45-4
英文名称:Hoechst 33258
分子式:C25H27Cl3N6O
分子量:533.88
储存条件:Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
纯度:HPLC≥98%
产品简介
| CAS | No.23491-45-4 |
| 英文名称 | Hoechst 33258 |
| 别名 | bisBenzimideH33258trihydrochloride;H33258trihydrochloride;赫斯特荧光燃料33258 |
| 分子式 | C25H27Cl3N6O |
| 分子量 | 533.88 |
| 溶解性 | Soluble in Water ≥10mg/mL |
| 纯度 | HPLC≥98% |
| 外观(性状) | Light yellow to green Solid |
| 储存条件 | Powder:-20℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-690-6 |
| MDL | MFCD00012679 |
| SMILES | OC1=CC=C(C2=NC3=CC=C(C4=NC5=CC=C(N6CCN(C)CC6)C=C5N4)C=C3N2)C=C1.[H]Cl.[H]Cl.[H]Cl |
| InChIKey | SMNPLAKEGAEPJD-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H24N6O.3ClH/c1-30-10-12-31(13-11-30)18-5-9-21-23(15-18)29-25(27-21)17-4-8-20-22(14-17)28-24(26-20)16-2-6-19(32)7-3-16;;;/h2-9,14-15,32H,10-13H2,1H3,(H,26,28)(H,27,29);3*1H |
| PubChem CID | 31953 |
| 背景说明 | Hoechst 33258 是一种可以穿透细胞膜的蓝色荧光染料,它在嵌入双链 DNA 后释放强烈的蓝色荧光,对细胞的毒性较低。Hoechst 33258 常用于细胞凋亡检测,染色后用荧光显微镜观察或流式细胞仪检测,也可以用于普通的细胞核染色,或常规的DNA染色。 |
| 规格 | 10mg 10mM*1mL in Water 50mg |
| 单位 | 瓶 |
Hoechst 33258 是一种可以穿透细胞膜的蓝色荧光染料，它在嵌入双链 DNA 后释放强烈的蓝色荧光，对细胞的毒性较低。 Hoechst 33258 常用于细胞凋亡检测，染色后用荧光显微镜观察或流式细胞仪检测，也可以用于普通的细胞核染色，或常规的DNA染色。Hoechst 33258染色常用于细胞凋亡检测，染色后用荧光显微镜观察或流式细胞仪检测。Hoechst 33258也常用于普通的细胞核染色，或常规的DNA染色。Hoechst 33258的最大激发波长为346nm，最大发射波长为460nm；Hoechst 33258和双链DNA结合后，最大激发波长为352nm，最大发射波长为461nm。
使用说明（仅供参考）：
1. 对于固定的细胞或组织：
a. 对于细胞或组织样品，固定后，适当洗涤去除固定剂。随后如果需要进行免疫荧光染色，则先进行免疫荧光染色，染色完毕后再按后续步骤进行Hoechst 33258染色。如果不需要进行其它染色，则直接进行后续的Hoechst 33258染色。
b. 对于贴壁细胞或组织切片，加入少量Hoechst 33258工作液，覆盖住样品即可；对于悬浮细胞，至少加入待染色样品3倍体积的工作液，混匀。室温放置3-5分钟。
c. 吸除Hoechst 33258染色液，用TBST、PBS或生理盐水洗涤2-3次，每次3-5分钟。
d. 直接在荧光显微镜下观察或封片后荧光显微镜下观察。细胞发生凋亡时，会看到凋亡细胞的细胞核呈致密浓染，或呈碎块状致密浓染。
2. 对于活细胞或组织：
a. 加入适当量Hoechst 33258工作液，必须充分覆盖住待染色的样品，通常对于六孔板一个孔需加入1mL工作液，对于96孔板一个孔需加入100μL工作液。
b. 在适宜于细胞培养的温度下培养20-30分钟。弃染色液，用PBS或培养液洗涤2-3次即可进行荧光检测。
注意事项：
荧光染料都存在淬灭的问题，为减缓荧光淬灭可以使用抗荧光衰减封片剂。建议染色后尽量当天完成检测，活细胞或组织染色后应立即观察。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
In Vitro
Cell（A549, H226, and H460 cells，1 mL of Hoechst 33258 in the dark for 15 min）
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
实验图
暂无详情
Gong HZ, et al.Poult Sci. 2020 Jan;99(1)151-162.
Ding X, et al. Acta Neuropathol Commun. 2021 Jan 18;9(1)15.
Wu Y, et al.Front Pharmacol. 2025 May 13;16:1526952. doi: 10.3389/fphar.2025.1526952.
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Genes & Diseases
PMID：
36157492
Methionine sulfoxide reductase A deficiency aggravated ferroptosis in LPS-induced acute kidney injury by inhibiting the AMPK/NRF2 axis and activating the CaMKII/HIF-1α pathway
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Author：
LiJiao Yang, Jing-Jie Xiao, Lian Zhang, QianYu Lu, Bin-Bin Hu, Yu Liu, Jun-Xing Pu, Jun-Wei Hu, Hong Yu, XiaoYan Wu, Bai-Fang Zhang
IF：
7.1000
Publish_to：
FREE RADICAL BIOLOGY AND MEDICINE
PMID：
40288699
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy
点击查看 >>
Author：
Jinling Qin, Hongliang Li, Xuan Wang, Yixin Zhang, Yongtao Duan, Yongfang Yao, Hua Yang, Moran Sun
IF：
7.0880
Publish_to：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
PMID：
36162214
Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy
点击查看 >>
Author：
Tingting Chen, Bingxiang Ma, Shi Lu, Lupeng Zeng, Huaying Wang, Wanhua Shi, Linying Zhou, Yaokun Xia, Xi Zhang, Jing Zhang, Jinghua Chen
IF：
7.0330
Publish_to：
International Journal of Nanomedicine
PMID：
35974872
Multifunctional gene delivery vectors containing different liver-targeting fragments for specifically transfecting hepatocellular carcinoma (HCC) cells
点击查看 >>
Author：
Qingbin Meng, Qin Cheng, Taoran Wang, Jing Zhang, Long Tian, Chunlan Zeng, Changhao Zhang, Zhao Meng
IF：
7.0000
Publish_to：
Journal of Materials Chemistry B
PMID：
37791430
Protective effects of ginsenoside F2 on isoproterenol-induced myocardial infarction by activating the Nrf2/HO-1 and PI3K/Akt signaling pathways
点击查看 >>
Author：
Ying Cui, Jianfa Wu, Yanfang Wang, Dan Li, Furui Zhang, Xiaoman Jin, Meihui Li, Jing Zhang, Zhi Liu
IF：
6.7000
Publish_to：
PHYTOMEDICINE
PMID：
38669969
SRBI deficiency induces iron overload and ferroptosis in renal tubular epithelial cells via HIF-1α/TFR1 signaling pathway
点击查看 >>
Author：
Ms. Lijiao Yang, Ms. Qing Liu, Ms. Qianyu Lu, Dr. Jing-Jie Xiao, Mr. An-Yao Fu, Ms. Shan Wang, Ms. Lihua Ni, Mr. Jun-Wei Hu, Dr. Hong Yu, Prof. Xiaoyan Wu, Dr. Bai-Fang Zhang
IF：
6.6000
Publish_to：
ANTIOXIDANTS & REDOX SIGNALING
PMID：
38062756
Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus
点击查看 >>
Author：
Chen Yi, Qiao Saifeng, Liu Huiping, Xing Huizhen, Chen Pei
IF：
6.5900
Publish_to：
Frontiers in Nutrition
PMID：
35634368
Efficient Treatment of Rheumatoid Arthritis by Degradable LPCE Nano-Conjugate-Delivered p65 siRNA
点击查看 >>
Author：
Xiaohua Chen, Bailing Zhou, Yan Gao, Kaiyu Wang, Jieping Wu, Ming Shuai, Ke Men, Xingmei Duan
IF：
6.5250
Publish_to：
Pharmaceutics
PMID：
35057057
Structure–activity relationships of pH-responsive and ionizable lipids for gene delivery
点击查看 >>
Author：
Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang
IF：
6.5100
Publish_to：
INTERNATIONAL JOURNAL OF PHARMACEUTICS
PMID：
35181463
Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
点击查看 >>
Author：
Ding X; Xiang Z; Qin C; Chen Y; Tian H; Meng L; Xi
IF：
6.4690
Publish_to：
Acta Neuropathol Commun
PMID：
33461623
Fucosylated oligosaccharide Lacto-N-fucopentaose I ameliorates enterovirus 71 infection by inhibiting apoptosis
点击查看 >>
Author：
Xiaoxiang Gao, Yinghui Qiu, Luying Gao, Lizhu Zhang, Xiaoqing Li, Yuanyuan Liu, Chao Zhao
IF：
6.4430
Publish_to：
Food Chemistry-X
PMID：
35499022
Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy
点击查看 >>
Author：
Caihong Lu, Jinpeng Zheng, Yaning Ding, Yuanyuan Meng, Fangyun Tan, Wei Gong, Xiaoyang Chu, Xiaolong Kong, Chunsheng Gao
IF：
6.4190
Publish_to：
DRUG DELIVERY
PMID：
34866533
Liquiritigenin protects against myocardial ischemic by inhibiting oxidative stress, apoptosis, and L-type Ca2+ channels
点击查看 >>
Author：
Muqing Zhang, Jiaying Qi, Qianqian He, Donglai Ma, Jing Li, Xi Chu, Saijie Zuo, Yixin Zhang, Li Li, Li Chu
IF：
6.3880
Publish_to：
PHYTOTHERAPY RESEARCH
PMID：
35747908
Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment
点击查看 >>
Author：
Shanshan Chen, Changping Deng, Wenyun Zheng, Shihui Li, Yuping Liu, Tong Zhang, Chen Zhang, Yunhui Fu, Hui Miao, Fuzheng Ren, Xingyuan Ma
IF：
6.3210
Publish_to：
Pharmaceutics
PMID：
34575494
Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer
点击查看 >>
Author：
Jiang Jun, Huang DengLiang, Jiang Yuan, Hou Jing, Tian MeiYuan, Li JianHua, Sun Li, Zhang YaoGang, Zhang Tao, Li ZhiQin, Li ZhongCheng, Tong SiXian, Ma YanYan
IF：
6.2440
Publish_to：
Frontiers in Oncology
PMID：
34150616
A Novel Isaindigotone Derivative Displays Better Anti-Proliferation Activities and Induces Apoptosis in Gastric Cancer Cells
点击查看 >>
Author：
Kangjia Du, Chengjie Yang, Zhongkun Zhou, Yunhao Ma, Yanan Tian, Rentao Zhang, Hao Zhang, Xinrong Jiang, Hongmei Zhu, Huanxiang Liu, Peng Chen, Yingqian Liu
IF：
6.2080
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
35887375
Heterogeneous tissue construction by on-demand bubble-assisted acoustic patterning
点击查看 >>
Author：
Qinghao Hu, Xuejia Hu, Yang Shi, Li Liang, Jiaomeng Zhu, Shukun Zhao, Yifan Wang, Zezheng Wu, Fubing Wang, Fuling Zhou, Yi Yang
IF：
6.1000
Publish_to：
LAB ON A CHIP
PMID：
37006165
Keratin 17 Is Required for Lipid Metabolism in Keratinocytes and Benefits Epidermal Permeability Barrier Homeostasis
点击查看 >>
Author：
Bingyu Pang, Zhenlai Zhu, Chunying Xiao, Yixin Luo, Hui Fang, Yaxing Bai, Zhongbin Sun, Jingyi Ma, Erle Dang, Gang Wang
IF：
6.0810
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
35096815
Tumor Cell-Specific and Lipase-Responsive Delivery of Hydrogen Sulfide for Sensitizing Chemotherapy of Pancreatic Cancer.
点击查看 >>
Author：
Libing Tian, Rui Pei, Xiaojun Zhang, Kun Li, Yuting Zhong, Yougen Luo, Shu-Feng Zhou, Lichan Chen
IF：
6.0640
Publish_to：
Frontiers in Bioengineering and Biotechnology
PMID：
35898641
lnc001776 Affects CPB2 Toxin-Induced Excessive Injury of Porcine Intestinal Epithelial Cells via Activating JNK/NF-kB Pathway through ssc-let-7i-5p/IL-6 Axis
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Author：
Kaihui Xie, Zunqiang Yan, Qiaoli Yang, Xiaoyu Huang, Pengfei Wang, Xiaoli Gao, Jie Li, Shuangbao Gun
IF：
6.0000
Publish_to：
Cells
PMID：
37048109
Baicalein Ameliorates Myocardial Ischemia Through Reduction of Oxidative Stress, Inflammation and Apoptosis via TLR4/MyD88/MAPKS/NF-κB Pathway and Regulation of Ca2+ Homeostasis by L-type Ca2+ Channels
点击查看 >>
Author：
Jinghan Li, Yakun Yang, Hua Wang, Donglai Ma, Hongfang Wang, Li Chu, Yuanyuan Zhang, Yonggang Gao
IF：
5.9880
Publish_to：
Frontiers in Pharmacology
PMID：
35370644
Construction and antitumor properties of a targeted nano-drug carrier system responsive to the tumor microenvironment
点击查看 >>
Author：
Wenzhao Han, Junfeng Ke, Feng Guo, Fanwei Meng, Hui Li, Liping Wang
IF：
5.8750
Publish_to：
INTERNATIONAL JOURNAL OF PHARMACEUTICS
PMID：
34481009
Biocompatible recombinant type III collagen enhancing skin repair and anti-wrinkle effects
点击查看 >>
Author：
Mingzhu Ye, Yirui Fan, Caihong Fu, Huixia He, Jianxi Xiao
IF：
5.8000
Publish_to：
Biomaterials Science
PMID：
39436415
Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents
点击查看 >>
Author：
Kangjia Du, Wantong Ma, Chengjie Yang, Zhongkun Zhou, Shujian Hu, Yanan Tian, Hao Zhang, Yunhao Ma, Xinrong Jiang, Hongmei Zhu, Huanxiang Liu, Peng Chen, Yingqian Liu
IF：
5.7560
Publish_to：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
PMID：
35450499
Nano selenium-doped TiO2 nanotube arrays on orthopedic implants for suppressing osteosarcoma growth
点击查看 >>
Author：
Xiaodong Hu, Chunhai Ke, Jiaqi Zhong, Yujiong Chen, Jieyang Dong, Mingming Hao, Qi Chen, Jiahua Ni, Zhaoxiang Peng
IF：
5.7000
Publish_to：
Frontiers in Bioengineering and Biotechnology
PMID：
37731757
Mechanistic insights into the ameliorative effects of hypoxia-induced myocardial injury by Corydalis yanhusuo total alkaloids: based on network pharmacology and experiment verification
点击查看 >>
Author：
Jiaying Qi, Haoying Li, Yakun Yang, Xiaoqi Sun, Jianxin Wang, Xue Han, Xi Chu, Zhenqing Sun, Li Chu
IF：
5.6000
Publish_to：
Frontiers in Pharmacology
PMID：
38273838
The Antimicrobial and Antibiofilm Activity of Oregano Essential Oil against Enterococcus faecalis and Its Application in Chicken Breast
点击查看 >>
Author：
Xiangjun Zhan, Yingzhu Tan, Yingmei Lv, Jianing Fang, Yuanjian Zhou, Xing Gao, Huimin Zhu, Chao Shi
IF：
5.5610
Publish_to：
Foods
PMID：
35954060
Versatile Triblock Peptide Self-Assembly System to Mimic Collagen Structure and Function
点击查看 >>
Author：
Linyan Yao, Biyang Ling, Wenjie Huang, Shuangni Shi, Jianxi Xiao
IF：
5.5000
Publish_to：
BIOMACROMOLECULES
PMID：
38525550
Synergistic antibacterial and anti-biofilm mechanisms of ultrasound combined with citral nanoemulsion against Staphylococcus aureus 29213
点击查看 >>
Author：
Hui Yang, Xiangjun Zhan, Luyi Song, Shuai Cheng, Ruiying Su, Yingying Zhang, Du Guo, Xin Lü, Xiaodong Xia, Chao Shi
IF：
5.4000
Publish_to：
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
PMID：
36870235
MicroRNA-432 inhibits milk fat synthesis by targeting SCD and LPL in ovine mammary epithelial cells
点击查看 >>
Author：
Zhiyun Hao, Yuzhu Luo, Jiqing Wang, Jon G. H. Hickford, Huitong Zhou, Jiang Hu, Xiu Liu, Shaobin Li, Jiyuan Shen, Na Ke, Weiwei Liang, Zhaochun Huang
IF：
5.3960
Publish_to：
Food & Function
PMID：
34606535
Zeolitic Imidazolate Framework-8 with Encapsulated Naringin Synergistically Improves Antibacterial and Osteogenic Properties of Ti Implants for Osseointegration
点击查看 >>
Author：
Libing Wang, Fei Dai, Yusheng Yang, Zehua Zhang
IF：
5.3950
Publish_to：
ACS Biomaterials Science & Engineering
PMID：
35973211
Hydrogen Sulfide Attenuates Particulate Matter-Induced Emphysema and Airway Inflammation Through Nrf2-Dependent Manner
点击查看 >>
Author：
JiaG;YuS;SunW;YangJ;WangY;QiY;ChenY
IF：
5.3310
Publish_to：
Front Pharmacol
PMID：
32116706
Fluid shear stress regulates osteoblast proliferation and apoptosis via the lncRNA TUG1/miR-34a/FGFR1 axis
点击查看 >>
Author：
Xingwen Wang, Jinwen He, Hong Wang, Dacheng Zhao, Bin Geng, Shenghong Wang, Jiangdong An, Cuifang Wang, Hua Han, Yayi Xia
IF：
5.3100
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
34350720
A self-targeting MOFs nanoplatform for treating metastatic triple-negative breast cancer through tumor microenvironment remodeling and chemotherapy potentiation
点击查看 >>
Author：
Hao Wu, Ming Jin, Yanhong Liu, Shuangqing Wang, Chao Liu, Xiuquan Quan, Mingji Jin, Zhonggao Gao, Ying Jin
IF：
5.3000
Publish_to：
INTERNATIONAL JOURNAL OF PHARMACEUTICS
PMID：
39182743
Effects of antimony exposure on DNA damage and genome-wide variation in zebrafish (Danio rerio) liver
点击查看 >>
Author：
Qin Yao, Aijiang Yang, Xia Hu, HaiTao Zou, Jiangfeng Chen, Qing Li, Shenghan Lv, Xuegang Yu, Cixing Li
IF：
5.2020
Publish_to：
AQUATIC TOXICOLOGY
PMID：
37031539
Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke
点击查看 >>
Author：
Li Kemin, Ding Wancong, Li Xinrui, Gao Hao, Wang Shuang, Li Ting, Zhao Haiyu, Zhang Shengxiang
IF：
5.2000
Publish_to：
Journal of Neuroimmune Pharmacology
PMID：
39141019
Anti-cervical cancer effects of Compound Yangshe granule through the PI3K/AKT pathway based on network pharmacology
点击查看 >>
Author：
Chao Ma, Yongwei Gu, Chang Liu, Xiaomeng Tang, Jianchao Yu, Dan Li, Jiyong Liu
IF：
5.1950
Publish_to：
JOURNAL OF ETHNOPHARMACOLOGY
PMID：
36220511
Exopolysaccharide from Lactiplantibacillus plantarum YT013 and Its Apoptotic Activity on Gastric Cancer AGS Cells
点击查看 >>
Author：
Rentao Zhang, Zhongkun Zhou, Yunhao Ma, Kangjia Du, Mengze Sun, Hao Zhang, Hongyuan Tu, Xinrong Jiang, Juan Lu, Lixue Tu, Yuqing Niu, Peng Chen
IF：
5.1230
Publish_to：
Fermentation-Basel
PMID：
Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission
点击查看 >>
Author：
Yu Xu, Yue Zhang, Yao Xu, Guangyao Zang, Bo Li, Hao Xia, Wei Yuan
IF：
5.0850
Publish_to：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
PMID：
33971320
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6
点击查看 >>
Author：
Minmin Xu, Li Ren, Jinhua Fan, Lu Huang, Liming Zhou, Xuegang Li, Xiaoli Ye
IF：
5.0370
Publish_to：
LIFE SCIENCES
PMID：
34968467
A Calixarene Assembly Strategy of Combined Anti-Neuroinflammation and Drug Delivery Functions for Traumatic Brain Injury Therapy
点击查看 >>
Author：
Chunxiao Wang, Yu-Xuan Chang, Xi Chen, Lihuan Bai, Heping Wang, Yu-Chen Pan, Chunqiu Zhang, Dong-Sheng Guo, Xue Xue
IF：
4.9270
Publish_to：
MOLECULES
PMID：
35566317
Endoplasmic reticulum stress impairs trophoblast syncytialization through upregulation of HtrA4 and causes early-onset preeclampsia
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Author：
Yuan Xi, Liu Xiyao, Zhu Fangyu, Huang Biao, Lin Li, Huang Jiayu, Wen Li, Kilby Mark D., Baker Philip N., Fu Yong, Wu Weiwei, Qi Hongbo, Tang Jing, Tong Chao
IF：
4.9000
Publish_to：
JOURNAL OF HYPERTENSION
PMID：
37728094
Synthesis of 8-Fluoroneocryptolepine and Evaluation for Cytotoxic Activity against AGS Cancer Cells
点击查看 >>
Author：
Yun-Hao Ma, Wan-Tong Ma, Zhong-Kun Zhou, Xiu Huang, Xin-Rong Jiang, Kang-Jia Du, Meng-Ze Sun, Hao Zhang, Hong Fang, Yi Zhao, Hong-Mei Zhu, Huan-Xiang Liu, Peng Chen, Ying-Qian Liu
IF：
4.8030
Publish_to：
JOURNAL OF NATURAL PRODUCTS
PMID：
35191714
Regorafenib induces NOX5-mediated endoplasmic reticulum stress and potentiates the anti-tumor activity of cisplatin in non-small cell lung cancer cells
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Author：
Hehuan Sui, Sisi Xiao, Suping Jiang, Siyuan Wu, Haizhen Lin, Liyuan Cheng, Lihua Ye, Qi Zhao, Yun Yu, Lu Tao, Feng-Ming Kong, Xiaoying Huang, Ri Cui
IF：
4.8000
Publish_to：
NEOPLASIA
PMID：
36940556
Establishing an Animal Model of Cytomegalovirus Keratouveitis in Rats: Broad Infection of Anterior Segment Tissue by Cytomegalovirus
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Author：
Shuang Zhang, Yunxiao Zang, Qing Lu, Jiao Ma, Xuan Jiang, Jinghao Qu, Jiaxin Zhang, Rongmei Peng, Minhua Luo, Jing Hong
IF：
4.7990
Publish_to：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
PMID：
34698772
Platelets-Derived miR-200a-3p Modulate the Expression of ET-1 and VEGFA in Endothelial Cells by Targeting MAPK14
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Author：
Yang Jie, Xu Hong, Chen Kejie, Zheng Danni, Liu Shuang, Zhou Xia, Lin Yapeng, Cheng Hang, Luo Qin, Yang Min, Yan Xiaoyan, Hao Junli
IF：
4.7550
Publish_to：
Frontiers in Physiology
PMID：
35755441
Preparation and Biocompatibility Characterization of Silk Fibroin 3D Scaffolds
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Author：
Xiaolan Guo, Nan Lin, Shijun Lu, Feng Zhang, Baoqi Zuo
IF：
4.7000
Publish_to：
ACS Applied Bio Materials
PMID：
35014488
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes
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Author：
Shen Zhentong, Liu Ping, Sun Qian, Li Yizhou, Acharya Rabin, Li Xinjian, Sun Chao
IF：
4.6770
Publish_to：
APOPTOSIS
PMID：
34212271
Cathepsin C (CTSC) contributes to the antibacterial immunity in golden pompano (Trachinotus ovatus)
点击查看 >>
Author：
Qianying Diao, Hehe Du, Na Zhao, Ying Wu, Xiangyu Du, Yun Sun, Yongcan Zhou, Zhenjie Cao
IF：
4.6220
Publish_to：
FISH & SHELLFISH IMMUNOLOGY
PMID：
35952999
Synthetic flavagline derivative 1-chloroacetylrocaglaol promotes apoptosis in K562 erythroleukemia cells through miR-17-92 cluster genes
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Author：
Xijun Wu, Xinmei Yang, Krishnapriya M. Varier, Qing Rao, Jingrui Song, Lei Huang, Yubing Huang, Babu Gajendran, Zhixu He, Chunmao Yuan, Yanmei Li
IF：
4.6130
Publish_to：
ARCHIV DER PHARMAZIE
PMID：
36216575
Gut Microbiota Combined with Metabolomics Reveal the Mechanisms of Sika Deer Antler Protein on Cisplatin-Induced Hepatorenal Injury in Mice
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Author：
Lulu Wang, Lei Li, Zhenyi Wang, Pu Zhang, Jing Zhang
IF：
4.6000
Publish_to：
MOLECULES
PMID：
37764239
Discovery of novel amide derivatives against VEGFR-2/tubulin with potent antitumor and antiangiogenic activity
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Author：
Zhenling Liu, Shuqiang Mao, Huixia Li, Wei Liu, Jing Tao, Yuebing Lu, Hui Dong, Jie Zhang, Chuanjun Song, Yongtao Duan, Yongfang Yao
IF：
4.5000
Publish_to：
BIOORGANIC CHEMISTRY
PMID：
39094510
Development and Optimization of Chitosan Nanoparticle-Based Intranasal Vaccine Carrier
点击查看 >>
Author：
Xiaoyi Gao, Nan Liu, Zengming Wang, Jing Gao, Hui Zhang, Meng Li, Yimeng Du, Xiang Gao, Aiping Zheng
IF：
4.4120
Publish_to：
MOLECULES
PMID：
35011436
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway
点击查看 >>
Author：
Li Hongling, Dang Chunyan, Tai Xiaohui, Xue Li, Meng Yuna, Ma Shuping, Zhang Jing
IF：
4.3800
Publish_to：
Scientific Reports
PMID：
34294779
Enhancement of Anti-Proliferative Activity of the Extracts from Dehulled Adlay by Fermentation with Bacillus subtilis
点击查看 >>
Author：
Anyan Wen, Yong Zhu, Muhammad Mazhar, Likang Qin, Haiying Zeng, Yi Zhu
IF：
4.3500
Publish_to：
Foods
PMID：
34945511
Potential Anti-Tumor Activity of Nardoguaianone L Isolated from Nardostachys jatamansi DC. in SW1990 Cells
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Author：
SangCY;ZhengYD;MaLM;WangK;WangCB;ChaiT;EshbakovaKA
IF：
4.1480
Publish_to：
Molecules
PMID：
36364317
Schisandrin B suppresses osteosarcoma lung metastasis in vivo by inhibiting the activation of the Wnt/β‑catenin and PI3K/Akt signaling pathways
点击查看 >>
Author：
Yuping Wang, Jin Chen, Yanran Huang, Shengdong Yang, Tao Tan, Nan Wang, Jun Zhang, Caihong Ye, Mengqi Wei, Jinyong Luo, Xiaoji Luo
IF：
4.1360
Publish_to：
ONCOLOGY REPORTS
PMID：
35029287
Biological Efficacy Comparison of Natural Tussah Silk and Mulberry Silk Nanofiber Membranes for Guided Bone Regeneration
点击查看 >>
Author：
Yumao Chen, Ming Chen, Yang Gao, Feng Zhang, Min Jin, Shijun Lu, Minxuan Han
IF：
4.1320
Publish_to：
ACS Omega
PMID：
35721914
Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway
点击查看 >>
Author：
Wang Z. Wang L. Wang J. Luo J. Ruan H. Zhang J
IF：
4.1300
Publish_to：
Sci Rep
PMID：
32973191
Evaluation of the Effects of E-Cigarette Aerosol Extracts and Tobacco Cigarette Smoke Extracts on Human Gingival Epithelial Cells
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Author：
Le Su, Jilong Liu, Qiulin Yue, Song Zhang, Chen Zhao, Xin Sun, Jing Xu, Xingtao Jiang, Kunlun Li, Baojun Li, Lin Zhao
IF：
4.1000
Publish_to：
ACS Omega
PMID：
37008119
Terpenoids from Nardostachys jatamansi and their cytotoxic activity against human pancreatic cancer cell lines
点击查看 >>
Author：
Li-Mei Ma, Kai Wang, Xian-Hua Meng, Yi-Dan Zheng, Cheng-Bo Wang, Tian Chai, Mohammad Reza Naghavi, Chun-Yan Sang, Jun-Li Yang
IF：
4.0040
Publish_to：
PHYTOCHEMISTRY
PMID：
35561851
Exploring the mechanism of physcion-1-O-β-D-monoglucoside against acute lymphoblastic leukaemia based on network pharmacology and experimental validation
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Author：
Jing Liu, Yan Yang, Yan Zeng, Xiang Qin, Ling Guo, Wenjun Liu
IF：
4.0000
Publish_to：
Heliyon
PMID：
36923879
Lycorine inhibits cell proliferation, migration and invasion, and primarily exerts in vitro cytostatic effects in human colorectal cancer via activating the ROS/p38 and AKT signaling pathways
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Author：
Ping Zhang, Xiaohui Yuan, Tingting Yu, Huakun Huang, Chunmei Yang, Lulu Zhang, Shengdong Yang, Xiaoji Luo, Jinyong Luo
IF：
3.9060
Publish_to：
ONCOLOGY REPORTS
PMID：
33649853
A network pharmacology-based strategy for predicting the protective mechanism of Ginkgo biloba on damaged retinal ganglion cells
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Author：
Hua YU, Li-Hong DONG, Yan ZHANG, Qiang LIU
IF：
3.8870
Publish_to：
Chinese Journal of Natural Medicines
PMID：
35101250
The abrogation of GRP78 sensitizes liver cancer cells to lysionotin by enhancing ER stress-mediated pro-apoptotic pathway
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Author：
Zou Ying, Shi Hewen, Lin Haiyan, Wang Xiaoxue, Wang Guoli, Gao Yijia, Yi Fan, Yin Yancun, Li Defang, Li Minjing
IF：
3.8000
Publish_to：
CELL STRESS & CHAPERONES
PMID：
37326827
Antibacterial Activity of Thymoquinone Against Shigella flexneri and Its Effect on Biofilm Formation
点击查看 >>
Author：
Muxue Wang, Xiangjun Zhan, Xiao Ma, Ruixia Wang, Du Guo, Yingying Zhang, Jiangtao Yu, Yunhe Chang, Xin Lü, Chao Shi
IF：
3.7880
Publish_to：
Foodborne Pathogens and Disease
PMID：
36367548
Effect of Flammulina velutipes polysaccharides on endoplasmic reticulum stress-mediated apoptosis by activating PLC–IP3 pathway in HepG2 cells
点击查看 >>
Author：
Miao Ding, Kai Lv, Dongliang Zhang, Wentao Fan, Ivan Stève Nguepi Tsopmejio, Zhouyu Jin, Hui Song
IF：
3.6930
Publish_to：
JOURNAL OF FOOD SCIENCE
PMID：
36524795
Functional characterization of cathepsin B and its role in the antimicrobial immune responses in golden pompano (Trachinotus ovatus)
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Author：
Yang Shen, Han Zhang, Yongcan Zhou, Yun Sun, Haoran Yang, Zhenjie Cao, Qiwei Qin, Chunsheng Liu, Weiliang Guo
IF：
3.6360
Publish_to：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
PMID：
34081945
Novel nanotherapeutics for cancer immunotherapy by CTLA-4 aptamer-functionalized albumin nanoparticle loaded with antihistamine
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Author：
Yao Fengjiao, An Yacong, Lai Xialian, Li Xundou, Yu Zhen, Yang Xian-Da
IF：
3.6000
Publish_to：
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
PMID：
36966395
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway
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Author：
Yi Chen, Yan Zhang, Xinsheng Wang, Saifeng Qiao
IF：
3.5680
Publish_to：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
PMID：
37247193
Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow
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Author：
Yulan Liu, Hong Xiang, Wenfang Xiong, Jie Ouyang, Hengdao Liu, Shaoli Zhao, Jie Xiao, Jialing Li, Zhihao Shu, Xuewen Wang, Huiqin Liu, Jing Zhang, Jianing Fan, Ying Li, Shuhua Chen, Hongwei Lu
IF：
3.5410
Publish_to：
Diabetes & Vascular Disease Research
PMID：
35549572
Induction of tau pathology and motor dysfunction in mice by urinary exosomes from progressive supranuclear palsy patients
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Author：
Qiusha Li, Han Liu, Qingyong Zhu, Rui Zhang, Dongxiao Liang, Jingwen Zhang, Ruoqi Jin, Yongkang Chen, Chi Qin, Junfang Teng
IF：
3.5000
Publish_to：
BRAIN RESEARCH BULLETIN
PMID：
39111605
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway
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Author：
Yuhe Lei, Meiching Chan, Haiyan Liu, Wenyu Lyu, Lei Chen, Yinqin Zhong, Hua Gan, Mei Wang, Ming Qi, Yu Guo, Junshan Liu, Enxin Zhang
IF：
3.4640
Publish_to：
DISEASE MARKERS
PMID：
35899176
Huaier inhibits autophagy and promotes apoptosis in T-cell acute lymphoblastic leukemia by down-regulating SIRT1
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Author：
Xiang Qin, Xi Chen, Fan Wang, Fangfang Zhong, Yan Zeng, Wenjun Liu
IF：
3.4000
Publish_to：
Heliyon
PMID：
39286166
The anti-lipopolysaccharide effect of glycine via fibroblastic cell culture from the embryonic calipash tissue of Chinese soft-shelled turtle Pelodiscus sinensis
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Author：
Beining Zhou, Wei Song, Leyan Zhu, Zilian Deng, Guoying Qian, Caiyan Li
IF：
3.3850
Publish_to：
Aquaculture Reports
PMID：
Biofunctional hollow γ-MnO2 microspheres by a one-pot collagen-templated biomineralization route and their applications in lithium batteries
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Author：
Huixia He, Caihong Fu, Yongling An, Jinkui Feng, Jianxi Xiao
IF：
3.3610
Publish_to：
RSC Advances
PMID：
35496386
Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells
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Author：
Tubtimsri Sukannika, Chuenbarn Tiraniti, Manmuan Suwisit
IF：
3.3000
Publish_to：
BMC Complementary Medicine and Therapies
PMID：
39885507
SIRT3 mitigates neuroinflammation and mitochondrial damage post-hypoxic-ischemic brain injury
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Author：
Ke Yan, Jiarong Bian, Liang He, Bingwei Song, Linhai Shen, Yong Zhen
IF：
3.2000
Publish_to：
MOLECULAR IMMUNOLOGY
PMID：
39913947
Effects of laying breeder hens dietary β-carotene. curcumin. allicin. and sodium butyrate supplementation on the growth performance. immunity. and jejunum morphology of their offspring chicks
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Author：
Gong HZ. Wu M. Lang WY. Yang M. Wang JH. Wang YQ.
IF：
3.1960
Publish_to：
Poult Sci
PMID：
32416796
Protopanaxadiol and Protopanaxatriol Ginsenosides Can Protect Against Aconitine-induced Injury in H9c2 Cells by Maintaining Calcium Homeostasis and Activating the AKT Pathway
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Author：
Zhao Yan, Wang Haohao, He Chunyan, Zhang Shengbo, Wang Yu, Wang Yingping, Li Pingya, Liu Jinping
IF：
3.1050
Publish_to：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
PMID：
34369901
A novel acid polysaccharide from Boletus edulis: extraction, characteristics and antitumor activities in vitro
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Author：
Meng Ting, Yu Sha-sha, Ji Hai-yu, Xu Xiao-meng, Liu An-jun
IF：
2.9160
Publish_to：
GLYCOCONJUGATE JOURNAL
PMID：
33507460
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
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Author：
Deng Xinran, Zhang Yan, He Xiwei, Li Li, Yue Zhongbin, Liang Yong, Huang Yue
IF：
2.9000
Publish_to：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
PMID：
39538054
10-Gingerol alleviates hypoxia/reoxygenation-induced cardiomyocyte injury through inhibition of the Wnt5a/Frizzled-2 pathway
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Author：
Bin Zheng, Jiaying Qi, Panpan Liu, Muqing Zhang, Yuanyuan Zhang, Yucong Xue, Xue Han, Shan Xu, Li Chu
IF：
2.8630
Publish_to：
Food Science & Nutrition
PMID：
34262748
Inhibitory Effects of Trans-Cinnamaldehyde Against Pseudomonas aeruginosa Biofilm Formation
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Author：
Luyi Song, Hui Yang, Xinru Meng, Ruiying Su, Shuai Cheng, Haoran Wang, Xiangyang Bai, Du Guo, Xin Lü, Xiaodong Xia, Chao Shi
IF：
2.8000
Publish_to：
Foodborne Pathogens and Disease
PMID：
36779942
TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells
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Author：
Yu De-Chen, Chen Xiang-Yi, Zhou Hai-Yu, Yu De-Quan, Yu Xiao-Lei, Hu Yi-Cun, Zhang Rui-Hao, Zhang Xiao-Bo, Zhang Kun, Lin Mao-Qiang, Gao Xi-Dan, Guo Tao-Wen
IF：
2.7420
Publish_to：
MOLECULAR BIOLOGY REPORTS
PMID：
35032258
High LYRM4-AS1 predicts poor prognosis in patients with glioma and correlates with immune infiltration
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Author：
Hai yue Wang, Ying Xie, Hongzhen Du, Bin Luo, Zengning Li
IF：
2.7000
Publish_to：
PeerJ
PMID：
37810780
A Study of the Protective Effect of Bushen Huoxue Prescription on Cerebral Microvascular Endothelia Based on Proteomics and Bioinformatics
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Author：
Shao-Yang Zhao, Huan-Huan Zhao, Yi-Ming Li, Bao-Hua Wang, Sai-Mei Li
IF：
2.6500
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
35035499
Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway
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Author：
Huang Xiaoxue, Yi Yuling, Yong Jiangyan, Sun Jiayi, Song Zhen, Li Dongmei, Li Yan
IF：
2.6490
Publish_to：
JOURNAL OF ANTIBIOTICS
PMID：
34408288
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway
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Author：
Yuan Cai, Qing Du, Tian-Hao Deng, Bing-Bing Shen, Yan-Mei Peng, Pu-Hua Zeng, Song-Ren Yu
IF：
2.6300
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
34335843
MicroRNA-34a induces apoptosis in the human glioma cell line, A172, through enhanced ROS production and NOX2 expression
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Author：
SZ Li, YY Hu, J Zhao, YB Zhao, JD Sun, Y Yang
IF：
2.5590
Publish_to：
Biochemical and Biophysical Research Communication
PMID：
24393844
Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line
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Author：
Hui Wang, Yanbing Liu, Ziyu Guo, Kexin Wu, Yunhao Zhang, Yanan Tian, Baoyu Zhao, Hao Lu
IF：
2.5540
Publish_to：
RESEARCH IN VETERINARY SCIENCE
PMID：
35026629
Establishment of a cell line derived from the gills of Gymnocypris przewalskii, an endemic Schizothoracine fish from Qinghai Lake of Tibet Plateau
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Author：
Fulei Wei, Jian Liang, Miao Yue, Wengen Tian, Luxian Yu, Zhaohui Feng, Qiang Hua
IF：
2.5040
Publish_to：
JOURNAL OF FISH BIOLOGY
PMID：
36373002
Role of miRNA-324-5p-Modified Adipose-Derived Stem Cells in Post-Myocardial Infarction Repair
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Author：
Zhou Ji, Chan Wang, Qing Tong
IF：
2.5000
Publish_to：
International Journal of Stem Cells
PMID：
34158416
Hirsutanol A inhibits T‑acute lymphocytic leukemia Jurkat cell viability through cell cycle arrest and p53‑dependent induction of apoptosis
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Author：
Fangfang Zhong, You Yang, Danwei Ren, Sili Long, Xiang Qin, Jing Liu, Yan Zeng, Wenjian Lan, Wenzhe Ma, Wenjun Liu
IF：
2.4470
Publish_to：
Experimental and Therapeutic Medicine
PMID：
34055057
Exploring the Potential Mechanism of Costunolide-Induced MCF-7 Cells Apoptosis by Multi-Spectroscopy, Molecular Docking and Cell Experiments
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Author：
Dan Liu, Meng Zeng, Jing-Wen Pi, Mei-Jia Liu, Wei-Zhe Ding, Xue-Ying Mei, Jian-Li Liu, Xiang-Yu Cao
IF：
2.4080
Publish_to：
CHEMISTRY & BIODIVERSITY
PMID：
33855794
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition
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Author：
Xuejie Zhu, Xiaojie Chen, Guoli Wang, Dan Lei, Xiaoyu Chen, Kehao Lin, Minjing Li, Haiyan Lin, Defang Li, Qiusheng Zheng
IF：
2.2640
Publish_to：
BIOLOGICAL & PHARMACEUTICAL BULLETIN
PMID：
35908886
Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells
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Author：
Wang Xuxu, Qiao Jiahao, Zou Chaoyi, Zhao Yutao, Huang Yefei
IF：
2.2480
Publish_to：
ANTI-CANCER DRUGS
PMID：
33534411
Salidroside Induces Apoptosis in Human Gastric Cancer Cells via the Downregulation of ENO1/PKM2/GLUT1 Expression
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Author：
Ziying Dai, Xuan Zhang, Wuyan Li, Junxia Tang, Tingting Pan, Chenru Ma, Quanlin Guan
IF：
2.2330
Publish_to：
BIOLOGICAL & PHARMACEUTICAL BULLETIN
PMID：
34471002
Determination of the anticancer activity of standardized extract of Centella asiatica (ECa 233) on cell growth and metastatic behavior in oral cancer cells
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Author：
Manmuan Suwisit, Tubtimsri Sukannika, Chaothanaphat Nattaya, Issaro Nipatha, Tantisira Mayuree H., Manmuan Ponwit
IF：
2.1000
Publish_to：
Research in Pharmaceutical Sciences
PMID：
39035578
Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells
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Author：
Ren Chenxia, Wu Cuiling, Yang Changqing, Lian Changhong
IF：
2.0430
Publish_to：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
PMID：
33624781
Investigation of Mitochondrial Homeostasis Changes in Lens Epithelium of High-Myopic Cataract
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Author：
Chenghao Sun, Pengfei Li, Guowei Zhang, Wenjing Geng, Congyu Wang, Sijie Bao, Xi Liu, Min Ji, Huaijin Guan
IF：
2.0000
Publish_to：
CURRENT EYE RESEARCH
PMID：
38078672
Nitric oxide functions in stromal cell derived factor 1 induced cytoskeleton changes and the migration of Jurkat cells
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Author：
Jixian Luo, Dan Wei, Dingyun Li, Lan Wang
IF：
0.2370
Publish_to：
Oncology Letters
PMID：
30405809
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