CAS |
No.78712-43-3 |
中文名称 |
盐酸奥扎格雷 |
英文名称 |
Ozagrel Hydrochloride |
别名 |
OKY-046 hydrochloride |
分子式 |
C13H12N2O2·HCl |
分子量 |
264.71 |
溶解性 |
Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
纯度 |
≥98% |
外观(性状) |
White to off-white Solid |
储存条件 |
Powder:2-8℃,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year |
运输条件 |
冷藏运输 |
EC |
EINECS 928-470-0 |
MDL |
MFCD06795644 |
SMILES |
C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O.Cl |
InChIKey |
CWKFWBJJNNPGAM-IPZCTEOASA-N |
InChI |
InChI=1S/C13H12N2O2.ClH/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15;/h1-8,10H,9H2,(H,16,17);1H/b6-5+; |
PubChem CID |
6438130 |
靶点 |
thromboxaneA2 synthetase |
通路 |
Metabolic Enzyme&Protease |
背景说明 |
Ozagrel Hydrochloride是选择性血栓素A2合成酶抑制剂。 |
生物活性 |
Ozagrel hydrochloride (OKY-046 hydrochloride) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel hydrochloride is an antiplatelet agent, which selectively inhibits human platelet aggregationwith an IC50 of 53.12 μM[1]. |
IC50 |
TXA2 |
数据来源文献 |
[1]. Max Seidy Saito, et al. Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1591-601. |
规格 |
5mg 10mg 20mg 50mg 100mg 200mg |
单位 |
瓶 |