CAS |
No.601-57-0 |
中文名称 |
4-胆甾烯-3-酮 |
英文名称 |
4-Cholesten-3-one |
别名 |
(+)-4-Cholesten-3-one;胆甾烯酮 |
分子式 |
C27H44O |
分子量 |
384.64 |
溶解性 |
Soluble in Ethanol |
纯度 |
≥98% |
外观(性状) |
White to off-white Solid |
储存条件 |
Powder:2-8℃,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year |
EC |
EINECS 210-005-1 |
MDL |
MFCD00003663 |
SMILES |
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O |
InChIKey |
NYOXRYYXRWJDKP-GYKMGIIDSA-N |
InChI |
InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25H,6-16H2,1-5H3/t19-,22+,23-,24+,25+,26+,27-/m1/s1 |
PubChem CID |
91477 |
靶点 |
Others |
通路 |
Others |
背景说明 |
是胆固醇的中间氧化产物,在膜中具有很高的流动性,会影响胆固醇的翻转和外排。 |
生物活性 |
Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells[1-2]. |
数据来源文献 |
[1]. Rosenheim O, et al. The mechanism of coprosterol formation in vivo: 1. Cholestenone as an intermediate. Biochem J. 1943 Oct;37(4):513-4. [2]. Neuvonen M, et, al. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014 Aug 26;9(8):e103743. |
规格 |
250mg 500mg |
单位 |
瓶 |