| CAS |
No.2140-46-7 |
| 中文名称 |
25-羟基胆固醇 |
| 英文名称 |
25-Hydroxycholesterol |
| 别名 |
25-羟基胆固醇;5-胆甾烯-3β，25-二醇;25-HydroxyCholesterol; |
| 分子式 |
C27H46O2 |
| 分子量 |
402.65 |
| 溶解性 |
Soluble in DMSO |
| 纯度 |
≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD00057815 |
| SMILES |
CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| InChIKey |
CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| InChI |
InChI=1S/C27H46O2/c1-18(7-6-14-25(2，3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19，4)24(21)13-16-27(22，23)5/h8，18，20-24，28-29H，6-7，9-17H2，1-5H3/t18-，20+，21+，22-，23+，24+，26+，27-/m1/s1 |
| PubChem CID |
65094 |
| 靶点 |
Others |
| 通路 |
Others |
| 背景说明 |
据报道,25-Hydroxycholesterol有效且选择性抑制B细胞产生IgA。 |
| 生物活性 |
25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.[1] |
| In Vitro |
The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase，which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. |
| 数据来源文献 |
[1]. McDonald JG， et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2. |
| 规格 |
5mg 10mg 25mg 50mg 100mg |
| 单位 |
瓶 |
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英语
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