| 产品类型 |
多肽 |
| CAS |
No.57966-42-4 |
| 单字母序列 |
RYLPT |
| 三字母序列 |
Arg-Tyr-Leu-Pro-Thr |
| 分子式 |
C30H48N8O8 |
| 分子量 |
648.76 |
| 纯度 |
≥95% |
| 外观(性状) |
冻干粉;Lyophilized powder |
| 溶解性 |
H2O：100 mg/mL;
*超声助溶; |
| 盐体系 |
TFA盐;Trifluoroacetate salt |
| 来源 |
合成;Synthetic |
| 储存条件 |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 背景说明 |
Proctolin 是一种内源性五肽，用作兴奋性神经调节剂。 Proctolin is an endogenous pentapeptide that acts as an excitatory neuromodulator. |
| In Vitro |
Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems.
In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter.
Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster. Although a previous study showed that Proctolin is absent in B. mori, this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis. Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis. |
| 参考文献 |
[1] Brüstle, B. et.al. J. Exp. Biol. 204, 2627 (2001 );
[2] Brown, BE. and A. Starrat, J. Insect Physiol. 21, 1879 (1975);
[3] Wilkens, J. et al. J. Exp. Biol. 208, 737 (2005). |
| 研究领域 |
神经科学研究 |
| 规格 |
1mg 5mg 10mg |
| 单位 |
瓶 |
| 分类属性 |
目录肽 |
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