| 产品类型 |
多肽 |
| CAS |
No.568588-77-2 |
| 单字母序列 |
PVNFKFLSH |
| 三字母序列 |
Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His |
| 分子式 |
C53H77N13O12 |
| 分子量 |
1088.28 |
| 纯度 |
≥95% |
| 外观(性状) |
冻干粉;Lyophilized powder |
| 盐体系 |
TFA盐;Trifluoroacetate salt |
| 来源 |
合成;Synthetic |
| 储存条件 |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 运输条件 |
冷冻运输 |
| 背景说明 |
Hemopressin(rat) 是一种源自血红蛋白 α1 链的九肽，最初是从大鼠脑匀浆中分离出来的。Hemopressin(rat) 是口服有效的，选择性的 CB1 大麻素受体的反向激动剂。Hemopressin(rat) 在炎性疼痛模型中发挥抗伤害感受作用。Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models. |
| In Vivo |
Hemopressin(rat) causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE).
Oral administration of Hemopressin(rat) inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin(rat) treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats. |
| In Vitro |
未检测 |
| 参考文献 |
[1] Camila Squarzoni Dale, et al. Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin. em Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:105-6. |
| 研究领域 |
神经科学研究 |
| 规格 |
1mg 5mg 10mg |
| 单位 |
瓶 |
| 分类属性 |
目录肽 |
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