| 产品类型 |
多肽 |
| CAS |
No.235433-36-0 |
| 单字母序列 |
TPDINPAWYASRGIRPVGRF-NH2 |
| 三字母序列 |
Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2 |
| 别名 |
12-31-人催乳素释放肽;Prolactin-Releasing Peptide (12-31),human;PrRP20 (human) |
| 分子式 |
C104H158N32O26 |
| 分子量 |
2272.6 |
| 纯度 |
≥95% |
| 外观(性状) |
冻干粉;Lyophilized powder |
| 溶解性 |
H2O：100 mg/mL;
*超声助溶; |
| 盐体系 |
TFA盐;Trifluoroacetate salt |
| 来源 |
合成;Synthetic |
| 储存条件 |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 运输条件 |
冷冻运输 |
| 背景说明 |
Prolactin Releasing Peptide (12-31), human是催乳素释放肽的片段。Prolactin Releasing Peptide (1-31), human是高亲和力的 GPR10 配体，其引起催乳素的释放。Prolactin Releasing Peptide (12-31), human is a fragment of the prolactin releasing peptide (PrRP). Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. |
| In Vivo |
Following intracerebroventricular injection of Prolactin Releasing Peptide (1-31), human 5 nM there is a highly significant simulation of plasma LH that began at 10 minutes and is maintained over the course of the experiment. Plasma FSH increased at 20 minutes following ICV injection. Total plasma testosterone increased at 60 minutes post injection. |
| In Vitro |
The Prolactin Releasing Peptide (PrRP) is a C-terminally amidated, 31-amino acid peptide derived from a 98-amino acid precursor. Radioiodinated PrRP-(1-31) binds to its receptor with high affinity (1 nM) and stimulates calcium mobilization in CHOK1 cells stably transfected with the receptor. A series of N-terminal deletions reveals that the Prolactin Releasing Peptide (12-31) amino acid is equipotent to PrRP-(1-31). Further N-terminal deletions reduce the affinity of the ligand considerably.
Prolactin Releasing Peptide (PrRP) has been identified as a specific, high affinity endogenous ligand for GPR10. Prolactin Releasing Peptide (PrRP) preproprotein can be cleaved at two different positions to give rise to two forms of 31 or 20 amino acids; Prolactin Releasing Peptide (PrRP)-31 and Prolactin Releasing Peptide (PrRP)-20 respectively. Rat Prolactin Releasing Peptide (PrRP) has also been identified and occurs as 31 or 20 amino acid forms; these peptides are highly conserved between species. Human PrRP‐20, human PrRP‐31, rat PrRP‐20 and rat PrRP‐31 display high affinity for GPR10 receptors, with Ki values of 0.26±0.07, 1.03±0.41, 0.22±0.06 and 0.33±0.11 nM, respectively. |
| 参考文献 |
[1] Roland BL, et al. Anatomical distribution of prolactin-releasing peptide and its receptor suggests additional functions in the central nervous system and periphery. Endocrinology. 1999 Dec;140(12):5736-45. |
| 研究领域 |
新陈代谢 |
| 规格 |
1mg 5mg 10mg |
| 单位 |
瓶 |
| 分类属性 |
目录肽 |
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