| 产品类型 |
多肽 |
| CAS |
No.63555-63-5 |
| 单字母序列 |
ASHLGLAR |
| 三字母序列 |
Ala-Ser-His-Leu-Gly-Leu-Ala-Arg |
| 分子式 |
C35H61N13O10 |
| 分子量 |
823.95 |
| 纯度 |
≥95% |
| 外观(性状) |
冻干粉;Lyophilized powder |
| 溶解性 |
H2O：100 mg/mL;
*超声助溶; |
| 盐体系 |
TFA盐;Trifluoroacetate salt |
| 来源 |
合成;Synthetic |
| 储存条件 |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 背景说明 |
这八肽是C3a过敏毒素肽的一个COOH末端片段。在摩尔基础上，这种肽具有C3a的1-2%的生物活性，它引起啮齿类动物回肠和子宫收缩，释放大鼠肥大细胞中的血管活性胺，并增加豚鼠和人体皮肤的血管通透性。纯化的C3a和人工合成的C3a（70-77）部分保留了过敏毒素的活性，被证明直接与人类淋巴细胞相互作用。This octapeptide is a COOH-terminal fragment of the C3a anaphylatoxin peptide. On a molar basis, this peptide possesses 1-2% of the biological activities of C3a. It causes contraction of rodent ileum and uterus, release of vasoactive amines from rat mast cells, and increases vascular permeability in guinea pig and human skin. Both purified C3a and synthetic C3a (70-77), which retains partially the activity of anaphylatoxin, are shown to interact directly with human lymphocytes. |
| In Vitro |
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD.
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. The cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites. |
| 参考文献 |
[1] Tony E. Hugli and Bruce W. Erickson. PNAS 74, 1826 (1977);
[2]Payan, D. et al. J. exp Med 156, 756 (1982). |
| 研究领域 |
免疫学 |
| 规格 |
1mg 5mg 10mg |
| 单位 |
瓶 |
| 分类属性 |
目录肽 |
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