| CAS |
No.349438-38-6 |
| 英文名称 |
Alda-1 |
| 分子式 |
C15H11Cl2NO3 |
| 分子量 |
324.16 |
| 溶解性 |
Soluble in DMSO |
| 纯度 |
≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD02055160 |
| SMILES |
O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl |
| InChIKey |
NMKJFZCBCIUYHI-UHFFFAOYSA-N |
| InChI |
InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19) |
| PubChem CID |
831629 |
| 靶点 |
Aldehyde Dehydrogenase (ALDH) |
| 通路 |
Metabolic Enzyme&Protease |
| 背景说明 |
Alda-1是一种ALDH2激动剂。 |
| 生物活性 |
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).[1-2] |
| In Vitro |
Alda-1 alleviated liver injury after hepatic I/R. Pretreatment with Alda-1 significantly alleviated I/R-induced elevations of alanine aminotransferase and aspartate aminotransferase，and significantly blunted the pathological injury of the liver. Moreover，Alda-1 significantly inhibited ROS and proinflammatory cytokines production，4-HNE and MDA accumulation，and apoptosis. Increased ALDH2 activity was found after Alda-1 administration. No significant changes in ALDH2 expression were observed after I/R[2]. |
| 细胞实验 |
Animal Models: Male Sprague-Dawley rats(IR model); Dosages: 10 mg/kg; Administration: i.p.[2] |
| 动物实验 |
The H/R(Hypoxia/reoxygenation)group cells are incubated under a hypoxic atmosphere(95% N2+5% CO2)for 6 h followed by 120 min reoxygenation(95% air + 5% CO2). The control incubation is normoxic conditions(95% air + 5% CO2)for the entire experiment. In the H/R+Alda-1 group，cells are incubated with Alda-1(20 μM)for 60 min at 37℃(95% air/5% CO2)before exposure to hypoxia. Furthermore，BRL-3A cells are treated with 5 μM 4-HNE for 60min before exposure to hypoxia to estimate whether 4-HNE could affect H/R.[2] |
| 数据来源文献 |
[1] Samantha Perez-Miller， et al. Nat Struct Mol Biol. 2010， 17(2): 159-164.
[2] Zhang T， et al. Free Radic Res. 2018， 52(6):629-638. |
| 规格 |
1mg 5mg 10mg 25mg 50mg 100mg |
| 单位 |
瓶 |
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