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重组人胰岛素
CAS:No.11061-68-0
分子式:C257H383N65O77S6
分子量:5807.57
储存条件:-20℃，有效期3年
纯度:97.00%
英文名称:Recombinant Human Insulin
产品简介
| 别名 | 人胰岛素 |
| 英文名称 | Recombinant Human Insulin |
| CAS | No.11061-68-0 |
| 分子式 | C257H383N65O77S6 |
| 分子量 | 5807.57 |
| 储存条件 | -20℃，有效期3年 |
| 运输条件 | 冷冻运输 |
| 外观(性状) |
白色粉末
|
| 级别 | 细胞培养级 |
| 纯度 | 97.00% |
| 来源 | 酵母表达 |
| 溶解性 | 1.5mg/ml 10mM Hcl |
| 规格 | 20mg 100mg 1g |
| 单位 | 瓶 |
锌含量（Zinc Amount ）：≤1.0%（若实验要求去除锌离子，可将胰岛素溶解在稀醋酸内，加入过量EDTA螯合锌离子，然后等电点沉淀纯化胰岛素）
溶解性（Solubility）：不溶于中性pH水，溶于稀醋酸或稀盐酸（pH 2-3）
胰岛素（insulin）是胰腺中胰岛β细胞分泌的一种双链形式（α, β）的多肽激素，由51个氨基酸组成，其中α链包含21个氨基酸，β链包含30个氨基酸。两条链间通过二对二硫键连接，而α链自身还含有一对二硫键。胰岛素的分泌过程是：前胰岛素原的氨基末端携带有一段23-30氨基酸的信号肽，该信号肽可将前胰岛素原转移至内质网，然后立即被切断，释放出胰岛素原。胰岛素原由胰岛素β链、C-肽和α链组成，释放出的胰岛素原随即被转至高尔基体，在此被包装并转化成胰岛素，与C-肽一同释放至血液。
胰岛素是目前已知的机体内唯一能降低血糖的蛋白激素，不仅负责调控细胞对葡萄糖、氨基酸和脂肪酸的摄入，利用和储存，而且抑制糖原，蛋白质和脂肪的降解发生。不同物种胰岛素功能大体相同，只是氨基酸组成上的差异。人胰岛素结构见下：
本品为基因重组技术制备的全长序列的人胰岛素，分子量大约为5800 Da，结构与天然来源的人胰岛素相同，常用作细胞培养的辅助成分，常见使用浓度为1-10μg/ml。
母液配制和保存方法： 中性pH下胰岛素不溶于水，可溶于1%的稀醋酸或者0.5% 的稀盐酸（pH 2~3），建议配制1-10mg/ml的母液。母液按照单次使用剂量，分装冻存于-20℃，避免反复冻融。另外，用低蛋白吸附滤膜过滤除菌后的母液，或者加有合适的抑菌剂如0.1%的硫柳汞或叠氮化钠的母液，也可以放在2~8℃下贮存达6个月。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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Man Zhang, Hao Feng, Yahui Huang, Tianyi Hu, Jiaxiang Du, Yong Wang, Song Chen, Dengke Pan, Lan Zhu, Gang Chen
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XENOTRANSPLANTATION
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39994946
KLF2 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating Nrf2 Expression
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Jiujiu Chen, Lichao Deng
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3.2000
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INTERNATIONAL DENTAL JOURNAL
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40121852
The Effects of Tangning Ziyabitusi on Gut Microbiota and T lymphocyte Subsets in Impaired Glucose Regulation Rats
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Bingyao Zhao, Rebiya Nuli, Yi Jiao, Bing Zhang, Ling Wang, Yaqun Guan
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3.1150
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Frontiers in Bioscience-Landmark
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36224015
Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis
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Zhen Zhai, Tianlong Mu, Lina Zhao, Dongsheng Zhu, Xin Zhong, Yiliang Li, Chen Liang, Wei Li, Qingyuan Zhou
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3.0000
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Chemical Biology & Drug Design
PMID：
38230769
Development of an Independent Prognostic Signature Based on Three Hypoxia-Related Genes for Breast Cancer
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Hui Wang, Yu Guo, Peipei Zhang, Zhijun Lin, Di Yang, Jiaohong Chen, Zhanzhan Li, Chi Zhang, Haoyu Yang, Binghui Yan, Zhimin Han, Chuntao Tian
IF：
2.8090
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Computational and Mathematical Methods in Medicine
PMID：
36388159
The role of miR-199a-3p in inhibiting the proliferation of spermatogonial stem cells under heat stress
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Lifan Zhuo, Yue Zhou, Jia Tian, Yan Li, Zhiyuan Xie, Chengbin Pei, Bei Yan, Lianghong Ma
IF：
2.8000
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THERIOGENOLOGY
PMID：
37573635
Mechanisms of Mitochondria-Mediated Apoptosis During Eimeria tenella Infection
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Rui Bai, Hui Wang, Tiantian Yang, Yuqi Yan, Shuying Zhu, Chenyang Lv, Yang Pei, Jiale Guo, Jianhui Li, Xiaozhen Cui, Xiaoling Lv, Mingxue Zheng
IF：
2.7000
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Animals
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40003058
In vitro outcomes of quercetin on Candida albicans planktonic and biofilm cells and in vivo effects on vulvovaginal candidiasis. Evidences of its mechanisms of action
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Taozhi Deng, Ping Zhong, Runlong Lou, Xiaojun Yang
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2.6000
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TISSUE & CELL
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37295272
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Wei Guo, Renzeng Ciwang, Lei Wang, Shuer Zhang, Nan Liu, Jinshan Zhao, Lisheng Zhou, Hegang Li, Xiaoxiao Gao, Jianning He
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2.4000
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Veterinary Sciences
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38393088
Dihydromyricetin Suppresses Lipopolysaccharide-Induced Intestinal Injury Through Reducing Reactive Oxygen Species Generation and NOD-Like Receptor Pyrin Domain Containing 3 Inflammasome Activation
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Yicong Chang, Xinru Jiang, Zhenghua Ji, Yingchao Gong, Xianan Fan, Beili Hao, Liang Yuan, Ishfaq Muhammad, Rui Li, Changwen Li, Fangping Liu
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2.2000
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JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
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39618421
Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3
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Xue Hu, Baoliang Guo, Tong Sun, Wan Wang
IF：
2.1230
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Open Medicine
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37069941
LncIMF1 Promotes Adipogenesis of Porcine Intramuscular Preadipocyte by Sponging miR-187
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Feng Ming, Yi Xudong, Zhang Ziyi, Zhu Jiahua, Yu He, Ming Lianxi, Pang Weijun
IF：
2.1000
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BIOCHEMICAL GENETICS
PMID：
39961961
In vitro determination of osteo-adipogenic lineage choice of bone marrow stromal/stem cells (BMSCs)
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Dawei Qiu, Wanyi Wei, Jia Chen, Jingwen Huang, Yong Yang, Ziwei Luo
IF：
1.9000
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MethodsX
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38445171
METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells Under the Inflammatory Microenvironment Through the miR-141-3p/ZEB1 Axis
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Li Weijia, Alimujiang Adili
IF：
1.8000
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CELL BIOCHEMISTRY AND BIOPHYSICS
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39681812
Cerium End-Deposited Gold Nanorods-Based Photoimmunotherapy for Boosting Tumor Immunogenicity
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Li Wenyu, Liu Hu, Li Wenjuan, Zhang Qiujun, Zhang Qianyu, Hu Dandan
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1.7000
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Molecular & Cellular Toxicology
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Therapeutic effects of Hedyotis diffusa Willd in a COPD mouse model challenged with LPS and smoke
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Renping Liu Peihong Wang Caiqing Wu Juan Chen
IF：
1.4100
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Experimental
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PMID：
29545859
Screening of non-alcoholic steatohepatitis (NASH)-related datasets and identification of NASH-related genes
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Ming-Jiang Liu, Hu Jin, Yu-Bing Chen, Jing-Jing Yu, Zhen-Ya Guo, Song-Qing He, Yong-Lian Zeng
IF：
0.9000
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International Journal of Clinical and Experimental Pathology
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34093943
技术问答
（3）
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Q1：胰岛素的浓度配制是直接多少mg溶于多少ml，还是按照效价来计算配制的？若是按照效价，那怎么配制呢？Q2：配好的储备液后续实验稀释的时候，可以用完培稀释吗?2023-06-12 09:34:22
您好，Q1：常见使用浓度为1-10μg/ml,按照质量配置；Q2：制成储备液后可以用培养基稀释。
功能活性是多少?2023-05-10 11:23:11
您好，收到货后可以参考产品标签的详细信息。
重组人胰岛素的溶解条件是什么样的吗？我要用在细胞上，如果按照说明书的溶于稀醋酸或稀盐酸（pH 2-3），这个母液如果影响了培养环境的PH怎么办呢?2023-02-16 15:04:27
您好，用作细胞培养的辅助成分，常见使用浓度为1-10μg/ml，对环境pH的影响不会特别大。