中文
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佛波酯 PMA
CAS:No.16561-29-8
分子式:C36H56O8
分子量:616.8
储存条件:-20℃ 避光保存，有效期2年
纯度:≥98%
英文名称:Phorbol 12-myristate 13-acetate
产品简介
| 别名 | PMA,TPA,Phorbol ester,croton oil，PMA，TPA，佛波酯，巴豆油，12-O-十四烷酰基佛波醇-13-乙酸酯 |
| 英文名称 | Phorbol 12-myristate 13-acetate |
| CAS | No.16561-29-8 |
| 分子式 | C36H56O8 |
| 分子量 | 616.8 |
| 储存条件 | -20℃ 避光保存，有效期2年 |
| 外观(性状) | 结晶固体 |
| 纯度 | ≥98% |
| 来源 | 青霉菌 |
| 溶解性 | 10mg/Ml in DMSO |
| 规格 | 1mg 5mg |
| 单位 | 瓶 |
PMA（同义名：TPA）是一种广泛用于体内外实验的佛波酯(phorbol ester) PKC激活剂。PMA结合PKC(Ki =2.6 nM)并激活其功能，在细胞和组织中都呈现出极其广的抑制谱。PMA可以抑制Fas诱导的细胞凋亡，但又可以诱导HL-60细胞的凋亡。PMA是一种高效的肿瘤促进剂，可以促进小鼠皮肤瘤的形成。尽管PMA毒性较强，但是在人体内仍显示出抗白血病和抗中性白细胞减少的活性。
使用浓度：
PMA的具体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
Description:
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
Preparation and storage:
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 100mM..
本产品可能不适合用于诱导THP-1细胞分化为巨噬细胞。
注意事项：PMA可溶于DMSO,用DMSO溶解后的溶液作为储存液，-20度分装避光保存，用水试剂稀释后的溶液不能保存，建议现用现稀释。
备注：产品信息可能会有优化升级。请以实际标签信息为准。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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Frontiers in Physiology
PMID：
34305627
Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus
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Author：
Song Zhang, Wenxu Pan, Hongli Wang, Cheng Zhi, Yanhao Lin, Ping Wu, Qi Ren, Ping Wei, Rui Chen, Feng Li, Ying Xie, Chun Kwok Wong, Hong Tang, Zhe Cai, Wanfu Xu, Huasong Zeng
IF：
4.5290
Publish_to：
MEDIATORS OF INFLAMMATION
PMID：
35462789
RGS1 Enhancer RNA Promotes Gene Transcription by Recruiting Transcription Factor FOXJ3 and Facilitates Osteoclastogenesis Through PLC-IP3R-dependent Ca2+ Response in Rheumatoid Arthritis
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Author：
Yuan Lin, Jiang Nan, Li Yuxuan, Wang Xin, Wang Wei
IF：
4.5000
Publish_to：
INFLAMMATION
PMID：
38904871
M2 macrophages promote subconjunctival fibrosis through YAP/TAZ signalling
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Author：
Yiwei Wang, Xingchen Geng, Zhihua Guo, Dandan Chu, Ruixing Liu, Boyuan Cheng, Haohao Cui, Chengcheng Li, Jingguo Li, Zhanrong Li
IF：
4.4000
Publish_to：
ANNALS OF MEDICINE
PMID：
38335557
Long non-coding RNA SNHG16 silencing inhibits proliferation and inflammation in Mycobacterium tuberculosis-infected macrophages by targeting miR-140-5p expression
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Author：
Wenna Sun, Xiushuang Zhang, Xiong He, Junxian Zhang, Xiaomeng Wang, Wen Lin, XiaoFeng Wang, Xueqiong Wu
IF：
4.3930
Publish_to：
INFECTION GENETICS AND EVOLUTION
PMID：
35779785
ADAM17/PTGS2 Facilitates Pulmonary Fibrosis by Regulating Ferroptosis
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Author：
Suyan Yan, Yaqi Zhao, Wei Xu, Jin Zhang, Ying Zhang, Baocheng Liu, Xinya Li, Zhenzhen Ma, Qingrui Yang
IF：
4.3000
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
40077919
Characterization and function of circulating mucosal-associated invariant T cells and γδT cells in oral lichen planus
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Author：
Jing-Ya Yang, Fang Wang, Gang Zhou
IF：
4.2530
Publish_to：
JOURNAL OF ORAL PATHOLOGY & MEDICINE
PMID：
34637577
A novel anti-CD47 antibody with therapeutic potential for NK/T-cell lymphoma
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Author：
Liping Qin, Yajun Li, Ruolan Zeng, Yizi He, Xiaoyan Chen, Ling Xiao, Hui Zhou
IF：
4.1000
Publish_to：
Human Vaccines & Immunotherapeutics
PMID：
39348228
AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection
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Author：
Junhong Wang, Yibo Zhao, Tong Cui, Hongyu Bao, Ming Gao, Mingyang Cheng, Yu Sun, Yiyuan Lu, Jiayao Guan, Di Zhang, Yanlong Jiang, Haibin Huang, Chunwei Shi, Jianzhong Wang, Nan Wang, Jingtao Hu, Wentao Yang, Hongxi Qian, Qingrong Jiang, Guilian Yang, Yan
IF：
4.0000
Publish_to：
JOURNAL OF VIROLOGY
PMID：
39012142
IL-17 upregulates MCP-1 expression via Act1 / TRAF6 / TAK1 in experimental autoimmune myocarditis
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Author：
Xiao Huang, Zhuolun Li, Xinhe Shen, Na Nie, Yan Shen
IF：
3.9260
Publish_to：
CYTOKINE
PMID：
35183823
Exploration of the mechanism by which Huangqi Guizhi Wuwu decoction inhibits Lps-induced inflammation by regulating macrophage polarization based on network pharmacology
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Author：
Wang Sutong, Ji Tianshu, Wang Lin, Qu Yiwei, Wang Xinhui, Wang Wenting, Lv Mujie, Wang Yongcheng, Li Xiao, Jiang Ping
IF：
3.9000
Publish_to：
BMC Complementary Medicine and Therapies
PMID：
36624435
Lactobacillus Plantarum NC8 and its metabolite acetate alleviate type 1 diabetes via inhibiting NLRP3
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Author：
Yuting Zhang, Yanning Li, Xiuquan Wang, Jingshu Huang, Xize Feng, Chunwei Shi, Wentao Yang, Yanlong Jiang, Xin Cao, Jianzhong Wang, Haibin Huang, Yan Zeng, Nan Wang, Guilian Yang, Chunfeng Wang
IF：
3.8000
Publish_to：
MICROBIAL PATHOGENESIS
PMID：
37422174
Essential role of protein kinase C βI in icariin-mediated protection against atherosclerosis
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Author：
Zhang Yibing, Xu Dongsheng, Huang Peng, Zhang Yang, Li Qi, Fan Zhimin, Ren Liqun
IF：
3.7650
Publish_to：
JOURNAL OF PHARMACY AND PHARMACOLOGY
PMID：
33822184
Comprehensive analysis of M2 macrophage-derived exosomes facilitating osteogenic differentiation of human periodontal ligament stem cells
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Author：
Liao Xian-min, Guan Zheng, Yang Zhen-jin, Ma Li-ya, Dai Ying-juan, Liang Cun, Hu Jiang-tian
IF：
3.7470
Publish_to：
BMC Oral Health
PMID：
36575449
Mitochondrial DNA Programs Lactylation of cGAS to Induce IFN Responses in Patients with Systemic Lupus Erythematosus
点击查看 >>
Author：
Zhang Juan, Ji Huiyan, Liu Mengdi, Zheng Ming, Wen Zhenke, Shen Haili
IF：
3.6000
Publish_to：
JOURNAL OF IMMUNOLOGY
PMID：
39093026
NETs promote pathogenic cardiac fibrosis and participate in ventricular aneurysm formation after ischemia injury through the facilitation of perivascular fibrosis
点击查看 >>
Author：
Li He, Ruiqi Liu, Honghua Yue, Guonian Zhu, Li Fu, Hongying Chen, Yingqiang Guo, Chaoyi Qin
IF：
3.5750
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
34735877
Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance
点击查看 >>
Author：
Yang Zhang, Yuechen Chang, Ziwei Han, Ketao Ma, Xiansi Zeng, Li Li
IF：
3.4640
Publish_to：
DISEASE MARKERS
PMID：
36246554
Hydrogen sulfide mitigates ox‑LDL‑induced NLRP3/caspase‑1/GSDMD dependent macrophage pyroptosis by S‑sulfhydrating caspase‑1
点击查看 >>
Author：
Zhenli Jia, Xulin Zhang, Zhiyi Li, Hanyu Yan, Xiangqin Tian, Chenghua Luo, Ketao Ma, Ling Li, Liang Zhang
IF：
3.4000
Publish_to：
Molecular Medicine Reports
PMID：
38873985
Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice
点击查看 >>
Author：
Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun
IF：
3.3000
Publish_to：
CELL TRANSPLANTATION
PMID：
38353224
HMGB1 regulates Th17 cell differentiation and function in patients with psoriasis
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Author：
Xiaofeng Zhu, Yue Dou, Yawen Lin, Gaoping Chu, Jing Wang, Lei Ma
IF：
3.2000
Publish_to：
Immunity Inflammation and Disease
PMID：
38414294
Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by Activating Coiled-Coil Domain-Containing Protein 178
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Author：
Gu Yue, Chen Gang, Ning Xinwei
IF：
3.1000
Publish_to：
DIGESTIVE DISEASES AND SCIENCES
PMID：
38358459
Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN
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Author：
Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Sun
IF：
2.9960
Publish_to：
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
PMID：
36367154
Diagnostic value of lncRNA NORAD in pulmonary tuberculosis and its regulatory role in Mycobacterium tuberculosis infection of macrophages
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Author：
Wenna Sun, Xiong He, Xiushuang Zhang, Xiaomeng Wang, Wen Lin, Xiaofeng Wang, Yan Liang
IF：
2.9620
Publish_to：
MICROBIOLOGY AND IMMUNOLOGY
PMID：
35568971
Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1
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Author：
Xiumei Wen, Beihui He, Xing Tang, Bin Wang, Zhiyun Chen
IF：
2.9520
Publish_to：
Molecular Medicine Reports
PMID：
34498715
Keratinocytes stimulate MAIT cells to produce granzyme B via MR1 and cytokines in oral lichen planus
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Author：
Qin Jiang, Fang Wang, Gang Zhou
IF：
2.9000
Publish_to：
ORAL DISEASES
PMID：
38937944
The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection
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Author：
Qianwei Yang, Yiqun Zhou, Waqas Farooq, Qimiao Liu, Jinhui Duan, Li Xing, Changxin Wu, Li Dong
IF：
2.8000
Publish_to：
TUBERCULOSIS
PMID：
39709721
Investigation and assessment of neutrophil dysfunction early after severe burn injury
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Author：
Yunxi Yang, Lu Liu, Zaiwen Guo, Linbin Li, Yiming Shao, Mingming Song, Bingwei Sun
IF：
2.7440
Publish_to：
BURNS
PMID：
33820675
X-ray irradiation effectively inactivated lymphocytes in transfusion in vivo monitored by the bioluminescence transfusion-associated graft-versus-host disease model
点击查看 >>
Author：
Dongxin Peng, Wenyuan Bai, Can Zhang, Xindai Chang, Ping Ma, Xiaohui Wang, Sujing Sun, Linsheng Zhan
IF：
2.7000
Publish_to：
VOX SANGUINIS
PMID：
38226529
Functions of Monocytes and Macrophages and the Associated Effective Molecules and Mechanisms at the Early Stage of Atherosclerosis
点击查看 >>
Author：
Liyuan Jin, Zihui Deng, Yongyi Bai, Ping Ye
IF：
2.6720
Publish_to：
Acta Cardiologica Sinica
PMID：
34584385
ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B
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Author：
Fang Wang, Jiangbo Huang, Shun Zeng, Ying Pan, Hao Zhou
IF：
2.6000
Publish_to：
GENE
PMID：
38880187
Fritillaria cirrhosa D. Don Alleviates Inflammatory Progression and Suppresses M1 Polarization of Macrophages in Chronic Obstructive Pulmonary Disease
点击查看 >>
Author：
Li Lei, Sun Jihui, Li Qian, Sun Kexin, Jiang Jianhua
IF：
2.5000
Publish_to：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
PMID：
39284286
Palmitic acid up regulates Gal‑3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF‑κB
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Author：
Jing Li, Yu-Shan Mao, Fen Chen, Dong-Xia Xia, Tin-Qi Zhao
IF：
2.4470
Publish_to：
Experimental and Therapeutic Medicine
PMID：
34373714
METTL3/IGF2BP1 influences the development of non-small-cell lung cancer by mediating m6A methylation modification of TRPV1
点击查看 >>
Author：
Wenjie Bai, Gang Xiao, Guijing Xie, Zhibo Chen, Xie Xu, Jie Zeng, Jianjiang Xie
IF：
2.3000
Publish_to：
Thoracic Cancer
PMID：
39090761
Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization
点击查看 >>
Author：
Wen P. Yu, Jing L. Ding, Xin L. Liu, Guo D. Zhu, Feng Lin, Jian J. Xu, Ziyao Wang, Jian L. Zhou
IF：
2.2390
Publish_to：
Immunity Inflammation and Disease
PMID：
33835721
The influence of cigR gene on the pathogenicity of Salmonella paratyphi A in vitro and in vivo
点击查看 >>
Author：
Junlei Yin, Wang Lijun, Shen Ronghua, He Jinjiao, Li Shaozu, Wang Huajian, Cheng Zhao
IF：
2.2000
Publish_to：
FEMS MICROBIOLOGY LETTERS
PMID：
39165135
The effects of thioredoxin peroxidase from Cysticercus cellulosae excretory-secretory antigens on TGF-β signaling pathway and Th17 cells differentiation in Jurkat cells by transcriptomics
点击查看 >>
Author：
Sun Xiaoqing, Mu Qianqian, Yang Fengjiao, Liu Meichen, Zhou Biying
IF：
2.0000
Publish_to：
PARASITOLOGY RESEARCH
PMID：
38095704
Transthyretin promotes the invasion of combined hepatocellular cholangiocarcinoma by tumor-associated macrophages
点击查看 >>
Author：
Kun Ke, Junqing Lin, Ning Huang, Leye Yan, Rihua Liao, Weizhu Yang
IF：
1.7000
Publish_to：
Cancer Reports
PMID：
37688511
Follicular fluid exosomes regulate OVGP1 secretion in yak oviduct epithelial cells via autophagy in vitro
点击查看 >>
Author：
Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou
IF：
1.6000
Publish_to：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
PMID：
37340721
LPS and ATP-induced Death of PMA-differentiated THP-1 Macrophages and its Validation
点击查看 >>
Author：
Huan Wang, Yuejia Lan, Cuiping Chen, Lu Yang, Jiayi Sun, Yong Zeng, Jiasi Wu
IF：
1.2000
Publish_to：
Jove-Journal of Visualized Experiments
PMID：
38767387
技术问答
（9）
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。
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这个和IP1010只是纯度上的差别吗？确定不能用于THP-1细胞分化?2023-10-26 22:18:24
您好，诱导巨噬细胞分化建议使用纯度级别更高的IP1010。
这个货号的产品和货号IP1010只有纯度等级的区别吗？因为已经购买此货号无法更换。是否有实验证实本货号产品不能用于诱导THP-1细胞分化呢?2023-08-29 14:25:56
您好，IP1010纯度级别更高，满足于细胞实验的纯度需求。
用DMSO稀释后的试剂在负80可以保存多久?2023-08-22 11:22:31
您好，没有验证过在-80℃保存时间，该产品可溶于DMSO中在-20℃避光保存建议在一个月内使用。
为啥这个不能用于诱导THP-1细胞分化，是证实了吗？它和货号IP1010的有啥区别?2023-05-27 21:13:39
您好，诱导细胞分化建议使用IP1010，IP1010这个纯度等级更高。
可以用来诱导THP-1吗?2023-03-16 17:07:10
您好，我司暂时没有验证过诱导THP-1的实验，但如果用来诱导细胞，建议使用IP1010这种小分子化合物，纯度会相对高一点。