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SKU	北京总部	北京海淀	武汉	广州
IU0030-100mg	咨询	咨询	咨询	咨询
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IU0030-1mg	咨询	咨询	咨询	咨询
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IU0030-50mg	咨询	咨询	咨询	咨询
IU0030-200mg	咨询	咨询	咨询	咨询

SKU

北京总部

北京海淀

武汉

广州

IU0030-100mg

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IU0030-D-1ml

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IU0030-1mg

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IU0030-5mg

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IU0030-10mg

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IU0030-50mg

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IU0030-200mg

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CAS	No.77-52-1
中文名称	熊果酸
英文名称	Ursolic acid
别名	NSC-4060;Prunol;Urson;Malol
分子式	C₃₀H₄₈O₃
分子量	456.7
溶解性	Soluble in DMSO ≥10mg/mL
纯度	HPLC≥98%
外观(性状)	White to light yellow Solid
储存条件	Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year
EC	EINECS 201-034-0
MDL	MFCD00009621
SMILES	CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
InChIKey	WCGUUGGRBIKTOS-GPOJBZKASA-N
InChI	InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
PubChem CID	64945
靶点	Others
通路	Others
背景说明	Ursolic acid是一三萜羧酸化合物。
生物活性	Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid， exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
In Vitro	Ursolic acid induces phosphorylation of AMP-activated protein kinase alpha (AMPKα) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner[1].The combination of Ursolic acid (0.5 μM) and Leucine (10 μM) prove to be the most effective in promoting myogenic differentiation. The combination of Ursolic acid and Leucine significantly increase CK activity than treatment with either agent alone. The level of myosin heavy chain， a myogenic differentiation marker protein， is also enhanced by the combination of Ursolic acid and Leucine[2].Ursolic acid efficiently induces apoptosis， possibly via the downregulation of B-cell lymphoma 2 (Bcl-2)， the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3. Furthermore， the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase is increased by the administration of ursolic acid. In addition， Ursolic acid significantly suppresses the invasive phenotype of the SNU-484 cells and significantly decreases the expression of matrix metalloproteinase (MMP)-2[3].Ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in Ursolic acid-mediated mitochondrial translocation of cofilin-1 and apoptosis[4].
In Vivo	Ursolic acid treatment markedly improves the survival of septic rats， and attenuated CLP-induced lung injury， including reduction of lung wet/dry weight ratio， infiltration of leukocytes and proteins， myeloperoxidase activity， and malondialdehyde content. In addition， Ursolic acid significantly decreases the serum levels of tumor necrosis factor-α， interleukin-6， and interleukin-1β， inhibits the expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lung， which are involved in the productions of nitric oxide and prostaglandin E2[5].
数据来源文献	[1]. Yie Y， et al. Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPKα-mediated reduction of DNA methyltransferase 1. Mol Cell Biochem. 2014 Dec 30. [2]. Kim M， et al. The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblasts through the mTOR signaling pathway. Int J Mol Med. 2015 Mar;35(3):755-62. [3]. Kim ES， et al. Ursolic acid inhibits the invasive phenotype of SNU-484 human gastric cancer cells. Oncol Lett. 2015 Feb;9(2):897-902. [4]. Li R， et al. Ursolic Acid Promotes Apoptosis of SGC-7901 Gastric Cancer Cells through ROCK/PTEN Mediated Mitochondrial Translocation of Cofilin-1. Asian Pac J Cancer Prev. 2014;15(22):9593-7. [5]. Hu Z， et al. Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture. J Surg Res. 2014 Oct 22. pii: S0022-4804(14)00967-6.
规格	1mg 5mg 10mM*1mL in DMSO 10mg 50mg 100mg 200mg
单位	瓶