| CAS |
No.107534-93-0 |
| 中文名称 |
安五酯素 |
| 英文名称 |
Macelignan |
| 别名 |
安五脂素;安五酯素;HMS2219A18;austrobailignan6;UNII-8PP3614Z43;Macelignan; |
| 分子式 |
C20H24O4 |
| 分子量 |
328.4 |
| 溶解性 |
Soluble in DMSO |
| 纯度 |
HPLC≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD09953803 |
| SMILES |
OC1=CC=C(C[C@H](C)[C@H](C)CC2=CC=C(OCO3)C3=C2)C=C1OC |
| InChIKey |
QDDILOVMGWUNGD-UONOGXRCSA-N |
| InChI |
InChI=1S/C20H24O4/c1-13(8-15-4-6-17(21)19(10-15)22-3)14(2)9-16-5-7-18-20(11-16)24-12-23-18/h4-7,10-11,13-14,21H,8-9,12H2,1-3H3/t13-,14+/m0/s1 |
| PubChem CID |
10404245 |
| 靶点 |
Others |
| 通路 |
Others |
| 背景说明 |
Macelignan是一种具有生物活性的木脂素 。具有抗氧化,清除自由基和神经保护活性。 |
| 生物活性 |
Macelignan protects skin keratinocytes from UVB-induced damage and inhibits MMP-9 and COX-2 expression by attenuating the activation of MAPKs and PI3K/Akt.Macelignan has anti-inflammatory and neuroprotective effects.[1-2] |
| In Vitro |
Macelignan at a concentration of 0.1-1 microM increased the viability of HaCaT cells following UVB irradiation and inhibited MMP-9 secretion and COX-2 expression in a concentration-dependent manner. An inhibitory effect was also seen in the signal transduction network， where macelignan treatment reduced the activation of UVB-induced MAPKs， PI3K/Akt， and their downstream transcription factors.[1] |
| In Vivo |
Oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains.A Morris water maze was used to evaluate the status of the hippocampal-dependent spatial learning in control rats with an artificial cerebrospinal fluid infusion， rats with chronic LPS infusions， and rats with chronic LPS infusions and oral administrations of macelignan.The rats with chronic LPS infusions showed spatial memory impairments relative to the control rats in the performance of the memory task.Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions.[2] |
| 数据来源文献 |
[1]. Anggakusuma， et al. Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells. J Dermatol Sci
[2]. Chun-Ai Cui， et al. Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats. Neurosci Lett. 2008 Dec 19;448(1):110-4. |
| 规格 |
1mg 5mg 10mg 25mg 50mg |
| 单位 |
瓶 |
中文
英语
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