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羟基红花黄色素A

CAS:No.78281-02-4

英文名称:Hydroxysafflor yellow A

分子式:C27H32O16

分子量:612.53

储存条件:Powder:2-8℃,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year

纯度:HPLC≥98%

羟基红花黄色素A
小分子同系列3送1
货号:
IH0140
品牌:
Solarbio
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使用本产品的案例(仅供参考)

In Vitro

CellChondrocytes;2.5~ 40 μM HSYA;24h

For the in vitro study, to assess the anti-inflammatory effects of different concentrations of HSYA, cells were treated with 10 ng mL−1 IL-1β alone or in combination with HSYA pretreatment at different concentrations (2.5, 10, or 40 μM).     A control group was left untreated except for medium changes.     Cells were harvested after 24 h of incubation.     To investigate the activation of NF-κB and MAPKs, the duration of IL-1β stimulation was 2 h. Meanwhile, to explore functional changes, such as inflammatory or ECM markers, the duration was extended to 24 h.

来源文献:Hu ZC , Xie ZJ , Tang Q , Li XB , Fu X , Feng ZH , Xuan JW , Ni WF , Wu AM . Hydroxysafflor yellow A (HSYA) targets the NF-κB and MAPK pathways and ameliorates the development of osteoarthritis. Food Funct. 2018 Aug 15;9(8):4443-4456. doi: 10.1039/c8fo00732b. PMID: 30070297.


In Vivo

Mice(ten-week-old C57BL/6 male wild-type (WT) mice; 20 mg/kg/day HSYA; 腹腔注射,1次/天,8周)

After DMM, the HSYA treatment groups received HSYA administration for 20 mg/kg/day (the HSYA was dissolved in saline and injected intraperitoneally once a day for eight consecutive weeks).      Meanwhile, the mice in the DMM alone group received an equivalent volume of saline.      All animals were sacrificed after eight weeks post-surgery, and cartilage tissue samples were collected for iconographic and histological analysis.

来源文献:Hu ZC , Xie ZJ , Tang Q , Li XB , Fu X , Feng ZH , Xuan JW , Ni WF , Wu AM . Hydroxysafflor yellow A (HSYA) targets the NF-κB and MAPK pathways and ameliorates the development of osteoarthritis. Food Funct. 2018 Aug 15;9(8):4443-4456. doi: 10.1039/c8fo00732b. PMID: 30070297.

备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.

实验图
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Hu ZC , et al. Food Funct. 2018 Aug 15;9(8):4443-4456.
Hu ZC , et al. Food Funct. 2018 Aug 15;9(8):4443-4456.
Hu ZC , et al. Food Funct. 2018 Aug 15;9(8):4443-4456.
Hu ZC , et al. Food Funct. 2018 Aug 15;9(8):4443-4456.
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