| CAS |
No.512-04-9 |
| 中文名称 |
薯蓣皂苷元 |
| 英文名称 |
Diosgenin |
| 别名 |
薯蓣皂苷配基;Nitogenin;山药;薯蓣皂素 |
| 分子式 |
C27H42O3 |
| 分子量 |
414.63 |
| 溶解性 |
Soluble in Ethanol ≥5mg/mL;Soluble in Water/DMSO ＜ 1 mg/mL |
| 纯度 |
HPLC≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 208-134-3 |
| MDL |
MFCD00016887 |
| SMILES |
[C@@H]1(O)CC2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@]1([H])[C@H](C)[C@]4(OC[C@H](C)CC4)O[C@@]1([H])C3)CC=2 |&1:0,4,8,10,12,14,18,20,22,25,30,r| |
| InChIKey |
WQLVFSAGQJTQCK-VKROHFNGSA-N |
| InChI |
InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
| PubChem CID |
99474 |
| 靶点 |
STAT;Pdia3/ERp57 |
| 通路 |
JAK/STAT Signaling;ER Stress |
| 背景说明 |
是一种甾体皂苷，能够抑制 STAT3 信号通路；也是 Pdia3/ERp57 的激活剂。 |
| 生物活性 |
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. |
| In Vitro |
Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner，with maximum inhibition occurring at around 100 μM[1].In MC65 cells，a cellular AD model，diosgenin exhibited weak protective abilities at 1 μM，may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[3]. |
| In Vivo |
Diosgenin-treated 5XFAD mice exhibited significantly improved performance of object recognition memory. Diosgenin treatment significantly reduced amyloid plaques and neurofibrillary tangles in the cerebral cortex and hippocampus. Degenerated axons and presynaptic terminals that were only observed in regions closely associated with amyloid plaques were significantly reduced by diosgenin treatment. The 1，25D -membrane-associated，rapid response steroid-binding protein(1，25D -MARRS)was shown to be a target of diosgenin.[2] |
| 数据来源文献 |
[1]. Li F， et al. Diosgenin， a steroidal saponin， inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.
[2]. Tohda C， et al. Diosgenin is an exogenous activator of 1，25D -MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.
[3]. Jeremy E. Chojnacki， et al. Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry， 23 (2015) 7324–7331 |
| 规格 |
10mg 50mg |
| 单位 |
瓶 |
中文
英语
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