中文
英语
3-异丁基-1-甲基黄嘌呤
CAS:No.28822-58-4
分子式:C10H14N4O2
分子量:222.24
储存条件:-20℃，有效期2年
纯度:99.00%
英文名称:3-Isobutyl-1-Methylxanthine
产品简介
| 别名 | IBMX |
| 英文名称 | 3-Isobutyl-1-Methylxanthine |
| CAS | No.28822-58-4 |
| 分子式 | C10H14N4O2 |
| 分子量 | 222.24 |
| 储存条件 | -20℃，有效期2年 |
| 外观(性状) |
白色粉末至浅黄色粉末
|
| 纯度 | 99.00% |
| 溶解性 | 10mg/ml EtOH |
| 规格 | 50mg |
| 单位 | 瓶 |
cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶，cAMP的增加激活了PKA ，其结果是减少增殖，增加分化和诱发凋亡. IBMX抑制由苯肾上腺素诱导的色胺（来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM）的减少 。也作为腺苷受体拮抗剂。
溶解性： 10mg/ml乙醇，完全溶解。无色透明溶液
备注：产品信息可能会有优化升级。请以实际标签信息为准。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
实验图
暂无详情
相关产品
暂无相关产品
相关论文
更多
JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte-derived leptin
点击查看 >>
Author：
Wei Liu, Yi Zeng, Xinhui Hao, Xin Wang, Jiaxiang Liu, Tianyang Gao, Mengdi Wang, Jingyao Zhang, Miaomiao Huo, Ting Hu, Tianyu Ma, Die Zhang, Xu Teng, Hefen Yu, Min Zhang, Baowen Yuan, Wei Huang, Yunkai Yang, Yan Wang
IF：
16.2000
Publish_to：
Cancer Communications
PMID：
37658635
In vitro adipogenesis and long-term adipocyte culture in adipose tissue-derived cell banks
点击查看 >>
Author：
Haoxiang Chen, Xiaocheng Wang, Jian Wang, Xuelei Shi, Xinghuan Li, Jianlong Wang, Dan Li, Yonghua Zhu, Weihong Tan, Zhikai Tan
IF：
10.0200
Publish_to：
Biofabrication
PMID：
34044385
Chronic di(2-ethylhexyl) phthalate exposure at environmental-relevant doses induces osteoporosis by disturbing the differentiation of bone marrow mesenchymal stem cells
点击查看 >>
Author：
Yifan Zhang, Liugen Zheng, Dong Cheng, Changting Lei, Hui Li, Jun Zhou, Cuili Zhang, Fuyong Song, Tao Zeng, Xiulan Zhao
IF：
9.8000
Publish_to：
SCIENCE OF THE TOTAL ENVIRONMENT
PMID：
38190899
Effects of ultra-high pressure assisted extraction on the structure, antioxidant and hypolipidemic activities of Porphyra haitanensis polysaccharides
点击查看 >>
Author：
Mingjing Zheng, Xin Tian, Zhipeng Li, Tao Hong, Yanbing Zhu, Yuanfan Yang, Qingbiao Li, Hui Ni, Zedong Jiang
IF：
8.8000
Publish_to：
FOOD CHEMISTRY
PMID：
37948798
Exosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4/p38MAPK pathway
点击查看 >>
Author：
Liang Zun-Hong, Pan Nan-Fang, Lin Shi-Shuai, Qiu Zhi-Yang, Liang Ping, Wang Jun, Zhang Zhi, Pan Yun-Chuan
IF：
8.0790
Publish_to：
Stem Cell Research & Therapy
PMID：
35870977
Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR-24-3p/Igf2/PI3K-AKT-mTOR and Igf2bp2/Ucp1 axis
点击查看 >>
Author：
Shao Jiahao, Wang Meigui, Zhang Anjing, Liu Zheliang, Jiang Genglong, Tang Tao, Wang Jie, Jia Xianbo, Lai Songjia
IF：
8.0000
Publish_to：
CELLULAR AND MOLECULAR LIFE SCIENCES
PMID：
37587272
miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1
点击查看 >>
Author：
Lixue Wang, Yuhuai Xie, Wei Chen, Yu Zhang, Yongqing Zeng
IF：
7.6660
Publish_to：
Cells
PMID：
36611960
Synthesis and Biological Activity of Myricetin Derivatives Containing Pyrazole Piperazine Amide
点击查看 >>
Author：
Hu Shilin, Chen Bo, Zhou Jiannan, Liu Fangqi, Mao Tianjiao, Pathak Janak L., Watanabe Nobumoto, Li Jiang
IF：
7.4000
Publish_to：
Journal of Translational Medicine
PMID：
37268950
Differential expression profiles of long noncoding RNAs and mRNAs in human bone marrow mesenchymal stem cells after exposure to a high dosage of dexamethasone
点击查看 >>
Author：
Li Tao, Xu Yingxing, Wang Yingzhen, Jiang Yaping
IF：
6.8320
Publish_to：
Stem Cell Research & Therapy
PMID：
33407832
Lotus (Nelumbo nucifera Gaertn.) Leaf-Fermentation Supernatant Inhibits Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Obesity in High-Fat Diet-Induced Obese Rats
点击查看 >>
Author：
Yao He, Yue Tao, Liang Qiu, Wenfeng Xu, Xiaoli Huang, Hua Wei, Xueying Tao
IF：
6.7060
Publish_to：
Nutrients
PMID：
36297031
TRIM16 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Modulating CHIP-Mediated Degradation of RUNX2
点击查看 >>
Author：
Zhao Yi, Zhai Qiaoli, Liu Hong, Xi Xun, Chen Shuai, Liu Dongxu
IF：
6.6840
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
33490087
Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes
点击查看 >>
Author：
Mengjie Liu, Chaofan Li, Jingkun Qu, Shiyu Sun, Zitong Zhao, Weiwei Wang, Wei Lv, Yu Zhang, Yifan Cai, Fang Zhao, Fei Wu, Shuqun Zhang, Xixi Zhao
IF：
5.7000
Publish_to：
CANCER SCIENCE
PMID：
37489486
Endocytic protein Pal1 regulates appressorium formation and is required for full virulence of Magnaporthe oryzae
点击查看 >>
Author：
Deng Chen, Hong Hu, Wenhui He, Shimei Zhang, Mengxi Tang, Shikun Xiang, Caiyun Liu, Xuan Cai, Ahmed Hendy, Muhammad Kamran, Hao Liu, Lu Zheng, Junbing Huang, Xiao-Lin Chen, Junjie Xing
IF：
5.6630
Publish_to：
MOLECULAR PLANT PATHOLOGY
PMID：
34636149
miR-383-5p Regulates Preadipocyte Proliferation and Differentiation by Targeting RAD51AP1
点击查看 >>
Author：
Meigui Wang, Jiahao Shao, Xiaoxiao Zhang, Zheliang Liu, Tao Tang, Guanhe Chen, Siqi Xia, Kaisen Zhao, Zhe Kang, Wenqiang Sun, Xianbo Jia, Jie Wang, Songjia Lai
IF：
5.6000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
37762324
Cannabidiol Rescues TNF-α-Inhibited Proliferation, Migration, and Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells
点击查看 >>
Author：
Lina Yu, Liting Zeng, Zeyu Zhang, Guanxiong Zhu, Zidan Xu, Junyi Xia, Jinlong Weng, Jiang Li, Janak Lal Pathak
IF：
5.5000
Publish_to：
Biomolecules
PMID：
36671503
In vitro transdifferentiated signatures of goat preadipocytes into mammary epithelial cells revealed by DNA methylation and transcriptome profiling
点击查看 >>
Author：
Xiao-Ru Yan, Tao Shi, Jia-Ying Xiao, Ya-Fang Liu, Hui-Ling Zheng
IF：
5.4860
Publish_to：
JOURNAL OF BIOLOGICAL CHEMISTRY
PMID：
36257406
Deciphering Risperidone-Induced Lipogenesis by Network Pharmacology and Molecular Validation
点击查看 >>
Author：
Yun Fu, Ke Yang, Yepei Huang, Yuan Zhang, Shen Li, Wei-Dong Li
IF：
5.4350
Publish_to：
Frontiers in Psychiatry
PMID：
35509887
Naringenin modulates the NO‑cGMP‑PKG signaling pathway by binding to AKT to enhance osteogenic differentiation in hPDLSCs
点击查看 >>
Author：
Shenghong Li, Zhenqiang Xiong, Yuxin Lan, Qian Zheng, Li Zhang, Xiaomei Xu
IF：
5.4000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
PMID：
38940332
Effect of 2’-Fucosyllactose on Beige Adipocyte Formation in 3T3-L1 Adipocytes and C3H10T1/2 Cells
点击查看 >>
Author：
Siru Chen, Yankun Fu, Tianlin Wang, Zhenglin Chen, Peijun Zhao, Xianqing Huang, Mingwu Qiao, Tiange Li, Lianjun Song
IF：
5.2000
Publish_to：
Foods
PMID：
38002194
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity
点击查看 >>
Author：
Yi Chu, Sisi Gui, Yazhen Zheng, Jingwu Zhao, Yaxiang Zhao, Yingying Li, Xiaodong Chen
IF：
5.0000
Publish_to：
EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：
38402928
Collagen Membrane Derived from Fish Scales for Application in Bone Tissue Engineering
点击查看 >>
Author：
Liang Chen, Guoping Cheng, Shu Meng, Yi Ding
IF：
4.9670
Publish_to：
Polymers
PMID：
35808577
A novel study on the immunomodulatory effect of umbilical cord derived mesenchymal stem cells pretreated with traditional Chinese medicine Asarinin
点击查看 >>
Author：
Haiping He, Tonghua Yang, Fan Li, Lihua Zhang, Xiaosui Ling
IF：
4.9320
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
34492537
Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling
点击查看 >>
Author：
Jiahao Shao, Genglong Jiang, Yanhong Li, Meigui Wang, Tao Tang, Jie Wang, Xianbo Jia, Songjia Lai
IF：
4.9000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
38255968
17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy
点击查看 >>
Author：
Wu Mengjing, Qin Mengyu, Wang Xian
IF：
4.7000
Publish_to：
Natural Products and Bioprospecting
PMID：
37289308
Senolytic elimination of senescent cells improved periodontal ligament stem cell-based bone regeneration partially through inhibiting YAP
点击查看 >>
Author：
Linglu Jia, Han Xiao, Zhenghao Hao, Shaoqing Sun, Wenxi Zhao, Zikai Gong, Weiting Gu, Yong Wen
IF：
4.6000
Publish_to：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
PMID：
39971252
Empagliflozin Induces White Adipocyte Browning and Modulates Mitochondrial Dynamics in KK Cg-Ay/J Mice and Mouse Adipocytes
点击查看 >>
Author：
Xu Linxin, Xu Chaofei, Liu Xiangyang, Li Xiaoyu, Li Ting, Yu Xiaochen, Xue Mei, Yang Jing, Kosmas Constantine E., Moris Dimitrios, Sanchis-Gomar Fabian, Yoshida Naofumi, Berger Nathan A., Aronow Wilbert S., Sun Bei, Chen Liming
IF：
4.5660
Publish_to：
Frontiers in Physiology
PMID：
34777009
FNDC5 Promotes Adipogenic Differentiation of Primary Preadipocytes in Mashen Pigs
点击查看 >>
Author：
Wei Hei, Ziwei You, Jiaqi An, Tianzhi Zhao, Jiao Li, Wanfeng Zhang, Meng Li, Yang Yang, Pengfei Gao, Guoqing Cao, Xiaohong Guo, Chunbo Cai, Bugao Li
IF：
4.1410
Publish_to：
Genes
PMID：
36672836
Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway
点击查看 >>
Author：
Wenjing Zhang, Linglu Jia, Bin Zhao, Yixuan Xiong, Ya-Nan Wang, Jin Liang, Xin Xu
IF：
4.1010
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
PMID：
33537804
Supplementation of mixed Lactobacillus alleviates metabolic impairment, inflammation, and dysbiosis of the gut microbiota in an obese mouse model
点击查看 >>
Author：
Shulin Hou, Ruining Li, Yunyun Zhang, Ping Liang, Haishan Yang, Huili He, Lei Wang, Yaojun Sun, Tianru Jin, Zhizhen Liu, Jun Xie
IF：
4.0000
Publish_to：
Frontiers in Nutrition
PMID：
40206949
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch
点击查看 >>
Author：
Xun Xi, Yi Zhao, Hong Liu, Zixuan Li, Shuai Chen, Dongxu Liu
IF：
3.9050
Publish_to：
EXPERIMENTAL CELL RESEARCH
PMID：
33865812
Adipose tissue reconstruction facilitated with low immunogenicity decellularized adipose tissue scaffolds
点击查看 >>
Author：
Xun Yang, Lijuan Jin, Miaomiao Xu, Xiao Liu, Zhikai Tan, Lijun Liu
IF：
3.9000
Publish_to：
Biomedical Materials
PMID：
38518362
SGLT2 inhibitor canagliflozin reduces visceral adipose tissue in db/db mice by modulating AMPK/KLF4 signaling and regulating mitochondrial dynamics to induce browning
点击查看 >>
Author：
Jingru Qu, Lei Tian, Man Zhang, Bei Sun, Liming Chen
IF：
3.8000
Publish_to：
MOLECULAR AND CELLULAR ENDOCRINOLOGY
PMID：
38964727
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation
点击查看 >>
Author：
Wang Wei, Liu Kun, Xu Huan, Zhang Chongchong, Zhang Yifan, Ding Mengnan, Xing Chen, Huang Xin, Wen Qing, Lu Chunfeng, Song Lun
IF：
3.7000
Publish_to：
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
PMID：
38856814
Icariin promotes the repair of bone marrow mesenchymal stem cells in rabbit knee cartilage defects via the BMP/Smad pathway
点击查看 >>
Author：
Feng Jiao, Wang Tang, Jie Wang, Donghua Liu, Hongyi Zhang, Dongming Tang
IF：
3.6160
Publish_to：
Annals of Translational Medicine
PMID：
35845525
Lpcat3 deficiency promotes palmitic acid-induced 3T3-L1 mature adipocyte inflammation through enhanced ROS generation: Lpcat3 deficiency promotes adipocyte inflammation
点击查看 >>
Author：
Jiachun Hu, Yan Deng, Tingbo Ding, Jibin Dong, Yuning Liang, Bin Lou
IF：
3.5110
Publish_to：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
PMID：
36331295
Defining the role of 2,2’,4,4’-tetrabromodiphenyl ether in 3T3-L1 cellular differentiation by transcriptome sequencing analysis
点击查看 >>
Author：
Zao-Ling Liu, Aerna Qiayimaerdan, Yong Fan, Shu-Rui Jiang, Zunire Tuerxuna, Meng-Lin Wang, Haiqiemuhan Abudureheman
IF：
3.5000
Publish_to：
Adipocyte
PMID：
39644184
The Duck RXRA Gene Promotes Adipogenesis and Correlates with Feed Efficiency
点击查看 >>
Author：
Ziyi Pan, Xuewen Li, Dongsheng Wu, Xingyong Chen, Cheng Zhang, Sihua Jin, Zhaoyu Geng
IF：
3.0000
Publish_to：
Animals
PMID：
36830469
ADSCs Combined with Melatonin Promote Peripheral Nerve Regeneration through Autophagy
点击查看 >>
Author：
Ziqiang Zhang, Mengyu Zhang, Zhixiang Zhang, Yingying Sun, Jiajia Wang, Chenhao Chang, Xinyan Zhu, Monan Li, Yumei Liu
IF：
2.8030
Publish_to：
International Journal of Endocrinology
PMID：
35910940
Influence of cold-stimulated adipocyte supernatant on the expression of adhesion-related molecules in Schwann cell line
点击查看 >>
Author：
Tiefeng Zhang, Yaxin Gan, Yulan Bai, Weijiang Hao, Ziqi Zeng, Feng Wu, Xianqi Li
IF：
2.7000
Publish_to：
Biochemistry and Biophysics Reports
PMID：
37529013
MiR-128-1-5p regulates differentiation of ovine stromal vascular fraction by targeting the KLF11 5′-UTR
点击查看 >>
Author：
Jianhua Liu, Yu Liang, Liying Qiao, Dong Xia, Yangyang Pan, Wenzhong Liu
IF：
2.5660
Publish_to：
DOMESTIC ANIMAL ENDOCRINOLOGY
PMID：
35338828
Identification and expression analysis of receptors that mediate MIP regulating larval settlement in Urechis unicinctus
点击查看 >>
Author：
Shumiao Bai, Shutong Fan, Danwen Liu, Zhengrui Zhang, Zhifeng Zhang
IF：
2.4950
Publish_to：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
PMID：
35278715
Isolation, characterization and differentiation of dermal papilla cells from Small-tail Han sheep
点击查看 >>
Author：
Xinhui Luo, Jianqiang Liu, Pengju Zhang, Yongsheng Yu, Bin Wu, Qi Jia, Yanguang Liu, Cheng Xiao, Yang Cao, Haiguo Jin, Lichun Zhang
IF：
2.1410
Publish_to：
ANIMAL BIOTECHNOLOGY
PMID：
36542538
Microarray analysis of long non-coding RNAs related to osteogenic differentiation of human dental pulp stem cells
点击查看 >>
Author：
Xinyu Hao, Dongfang Li, Dongjiao Zhang, Linglu Jia
IF：
2.0800
Publish_to：
Journal of Dental Sciences
PMID：
35756759
TPT1 promotes the adipogenic differentiation of stromal vascular fractions via the PI3K/AKT pathway and FOXO1 in sheep
点击查看 >>
Author：
Liying Qiao, Bishi Zhao, Xuying Liu, Jianhua Liu, Kaijie Yang, Yangyang Pan, Wenzhong Liu
IF：
1.9870
Publish_to：
JOURNAL OF APPLIED ANIMAL RESEARCH
PMID：
METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells Under the Inflammatory Microenvironment Through the miR-141-3p/ZEB1 Axis
点击查看 >>
Author：
Li Weijia, Alimujiang Adili
IF：
1.8000
Publish_to：
CELL BIOCHEMISTRY AND BIOPHYSICS
PMID：
39681812
技术问答
（4）
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。
京公网安备 11011202000391号
3-异丁基-1-甲基黄嘌呤可以使用DMSO溶解吗？是需要100%DMSO1吗？溶解性怎么样?2023-09-27 14:39:12
您好，溶解性10mg/ml无水乙醇，如果用DMSO溶解10mM，再高浓度没有检测过，DMSO指的是纯品试剂。
这个能加到细胞里面吗?2023-09-08 17:17:26
您好，我们没有做过细胞的验证；试剂本身是非无菌的，如果用于细胞实验，可配制溶液后过滤除菌。
请问是用多少浓度的乙醇溶解?2023-07-21 20:49:48
您好，3-异丁基-1-甲基黄嘌呤可以使用无水乙醇溶解。
用无水乙醇溶解吗?2022-11-30 16:18:21
您好，可以使用无水乙醇溶解，溶解性为10mg/ml。