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蛋白酶抑制剂混合液(100×PIC)
英文名称:Protease inhibitor mixture
储存条件:Store at -20℃，avoid light，1 year
产品简介
| 英文名称 | Protease inhibitor mixture |
| 中文名称 | 蛋白酶抑制剂混合液(100×PIC) |
| 外观(性状) | 液体 |
| 储存条件 | Store at -20℃，avoid light，1 year |
| 规格 | 1ml |
| 单位 | 支 |
蛋白酶抑制剂(Protease Inhibitor)是指与蛋白酶分子活性中心上的一些基团结合，使蛋白酶活力下降甚至消失但不使酶蛋白变性的物质。
蛋白酶抑制剂有很多种，包括 EDTA、E-64、NaVO3、Bestatin、Leupetin、PepstatinA、Aprotinin 等均可有效抑制蛋白的降解，并维持原有的蛋白间相互作用。
蛋白酶抑制剂混合液(100×PIC)主要由 Leupetin、PepstatinA、Aprotinin、E-64 等组成，不含EDTA。
该混合物可以抑制绝大多数蛋白酶活性，包括丝氨酸蛋白酶、半胱胺酸蛋白酶、胃蛋白酶、胰蛋白酶、木瓜蛋白酶等。
该蛋白酶抑制剂混合液是 100×的浓缩的 DMSO 溶液，适用于从哺乳动物组织、细胞中提取蛋白质，能够更有效的获得目的蛋白质。
提取出来的蛋白可以用于 Western Blot、免疫共沉淀等试验。
操作步骤(仅供参考) ：
1、 开盖前请低速离心一下，以便将黏附于管壁的液体甩至管底。
2、 使用时,根据裂解液的用量加入蛋白酶抑制剂混合液(100×PIC)，使其终浓度达到1×。
注意事项：
1、 蛋白酶抑制剂混合液有轻微刺激性，小心操作，同时应避免反复冻融。
2、 为了您的安全和健康，请穿实验服并戴一次性手套操作。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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34579895
Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS
点击查看 >>
Author：
Mengting Zhou, Xingtao Zhao, Li Liao, Ying Deng, Meichen Liu, Jing Wang, Xinyan Xue, Yunxia Li
IF：
7.3100
Publish_to：
Oxidative Medicine and Cellular Longevity
PMID：
35035671
Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis
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Author：
Simin Sun, Zhuoyue Li, Chao Huang, Jinyu Liu, Qixin Yu, Xiaolin Jiang, Kairui Yue, Jianchun Zhao, Tongqiang Xu, Yankai Liu, Xiaoyang Li, Chong Qin, Yuqi Jiang
IF：
7.3000
Publish_to：
JOURNAL OF MEDICINAL CHEMISTRY
PMID：
38029358
Perfluoroalkyl substances promote breast cancer progression via ERα and GPER mediated PI3K/Akt and MAPK/Erk signaling pathways
点击查看 >>
Author：
Qianfeng Liu, Yongzhe Liu, Xiaoyu Li, Dan Wang, Ai Zhang, Jing Pang, Jiayu He, Xi Chen, Nai-jun Tang
IF：
7.1290
Publish_to：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
PMID：
37148752
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma
点击查看 >>
Author：
Li Yongjian, Cheng Qian, Gao Jie, Chen Zhuomiaoyu, Guo Jingheng, Li Zuyin, Tian Lingyu, Zhang Chao, Li Yuzi, Zheng Jiaxi, Li Zhao, Zhu Jiye
IF：
7.1090
Publish_to：
Cell Death Discovery
PMID：
35264565
SIRT1-dependent regulation of mitochondrial metabolism participates in miR-30a-5p-mediated cardiac remodeling post-myocardial infarction
点击查看 >>
Author：
Chan Wu, Yi-Xiang Hong, Xiao-Cheng Zhang, Jing-Zhou Li, Yu-Ting Li, Jun Xie, Rui-Ying Wang, Yan Wang, Gang Li
IF：
7.1000
Publish_to：
FREE RADICAL BIOLOGY AND MEDICINE
PMID：
39557133
HAX-1 interferes in assembly of NLRP3-ASC to block microglial pyroptosis in cerebral I/R injury
点击查看 >>
Author：
Guo Xin-bin, Deng Xin, Wang Jingjing, Qi Yuruo, Zhao Wen, Guan Sheng
IF：
7.0000
Publish_to：
Cell Death Discovery
PMID：
38811533
Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7
点击查看 >>
Author：
Xu-Feng Shi, Zhan Zhang, Hai-Ying Wu, Yu Wang, Ai-Min Chang, Jun-Jun Gao, Kan Liu, Wan-Yu Song, Li Wang, Huan-Ping Wang
IF：
6.8320
Publish_to：
Bioengineered
PMID：
35331081
Ginsenoside Rh4 Suppresses Metastasis of Esophageal Cancer and Expression of c-Myc via Targeting the Wnt/β-Catenin Signaling Pathway
点击查看 >>
Author：
Jun Chen, Zhiguang Duan, Yannan Liu, Rongzhan Fu, Chenhui Zhu
IF：
6.7060
Publish_to：
Nutrients
PMID：
35893895
Synthesis of cinnamoyl tethered indoline derivatives with anti-inflammatory and antioxidant activities
点击查看 >>
Author：
Yongpeng Liu, Jing Sun, Yichuan Ran, Lifang Zheng
IF：
6.7000
Publish_to：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
PMID：
37976711
Long Non-coding RNA FER1L4 Mediates the Autophagy of Periodontal Ligament Stem Cells Under Orthodontic Compressive Force via AKT/FOXO3 Pathway
点击查看 >>
Author：
Huang Yiping, Liu Hao, Guo Runzhi, Han Yineng, Yang Yuhui, Zhao Yi, Zheng Yunfei, Jia Lingfei, Li Weiran
IF：
6.6840
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
33604341
Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings
点击查看 >>
Author：
Yong-Ping Fu, Huan Yuan, Yan Xu, Ru-Ming Liu, Yi Luo, Jian-Hui Xiao
IF：
6.6560
Publish_to：
PHYTOMEDICINE
PMID：
35299029
Curcumin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice Through Regulating Gut Microbiota
点击查看 >>
Author：
Xiaoxuan Guo, Ye Xu, Ruixuan Geng, Jing Qiu, Xiaoyun He
IF：
6.5750
Publish_to：
MOLECULAR NUTRITION & FOOD RESEARCH
PMID：
35106903
miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxity by Inhibiting CyclinG1
点击查看 >>
Author：
闫明静
IF：
6.5430
Publish_to：
Oxidative Medicine and Cellular Longevity
PMID：
35186188
Pien-Tze-Huang, a Chinese patent formula, attenuates NLRP3 inflammasome-related neuroinflammation by enhancing autophagy via the AMPK/mTOR/ULK1 signaling pathway
点击查看 >>
Author：
Zhenwei Huang, Xian Zhou, Xiaoqin Zhang, Lili Huang, Yibin Sun, Zaixing Cheng, Wen Xu, Chun-Guang Li, Yanfang Zheng, Mingqing Huang
IF：
6.5300
Publish_to：
BIOMEDICINE & PHARMACOTHERAPY
PMID：
34146853
DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
点击查看 >>
Author：
Pinhua Wang, Sunayana Sarkar, Menghuan Zhang, Tingting Xiao, Fenhua Kong, Zhe Zhang, Deepa Balasubramanian, Nandan Jayaram, Sayantan Datta, Ruyu He, Ping Wu, Peng Chao, Ying Zhang, Michael Washburn, Laurence A Florens, Sonal Nagarkar-Jaiswal, Manish Jaisw
IF：
6.4000
Publish_to：
eLife
PMID：
39436397
Novel MSX1 variants identified in families with nonsyndromic oligodontia
点击查看 >>
Author：
Zheng Jinglei, Yu Miao, Liu Haochen, Cai Tao, Feng Hailan, Liu Yang, Han Dong
IF：
6.3440
Publish_to：
International Journal of Oral Science
PMID：
33419968
The mediation of the AHR/IL-22/STAT3/IL-6 axis by soft-shelled turtle (Pelodiscus sinensis) peptide and Chinese pond turtle (Chinemys reevesii) peptide contributed to their amelioration effects on intestinal mucosal immunity in immunosuppressed mice
点击查看 >>
Author：
Jiachen Zhuang, Qianqian Wang, Fei Shen, Jing Wang, Juan Du, Peng Yu, Fengqin Feng, Minjie Zhao
IF：
6.3170
Publish_to：
Food & Function
PMID：
37102758
The AURKA inhibitor alters the immune microenvironment and enhances targeting B7-H3 immunotherapy in glioblastoma
点击查看 >>
Author：
Jinqiu Liu, Yuxuan Deng, Zhuonan Pu, Yazhou Miao, Zhaonian Hao, Herui Wang, Shaodong Zhang, Hanjie Liu, Jiejun Wang, Yifan Lv, Boyi Hu, Hong Wan, Zhengping Zhuang, Tai Sun, Shuyu Hao, Nan Ji, Jie Feng
IF：
6.3000
Publish_to：
JCI Insight
PMID：
39928563
Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer
点击查看 >>
Author：
Dong Xubin, Lv Shihui, Gu Dianna, Zhang Xiaohua, Ye Zhiqiang
IF：
6.2440
Publish_to：
Frontiers in Oncology
PMID：
33552947
Hepatocyte-Specific Smad4 Deficiency Alleviates Liver Fibrosis via the p38/p65 Pathway
点击查看 >>
Author：
Miaomiao Wei, Xinlong Yan, Xin Xin, Haiqiang Chen, Lingling Hou, Jinhua Zhang
IF：
6.2080
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
36232998
Targeting scleral remodeling and myopia development in form deprivation myopia through inhibition of EFEMP1 expression
点击查看 >>
Author：
Wen-Qing Shi, Tao Li, Rongbin Liang, Bing Li, Xiaodong Zhou
IF：
6.2000
Publish_to：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
PMID：
38101653
Combined biological effects and lung proteomics analysis in mice reveal different toxic impacts of electronic cigarette aerosol and combustible cigarette smoke on the respiratory system
点击查看 >>
Author：
Yang Wanchun, Yang Xuemin, Jiang Lujing, Song Hongjia, Huang Guangye, Duan Kun, Jiang Xingtao, Li Min, Liu Peiqing, Chen Jianwen
IF：
6.1680
Publish_to：
ARCHIVES OF TOXICOLOGY
PMID：
36173423
Effect of Mitophagy in the Formation of Osteomorphs Derived from Osteoclasts
点击查看 >>
Author：
Tingben Huang, Yuchen Wang, Zhou Yu, Xiaoyan Miao, Zhiwei Jiang, Ke Yu, Mengdie Fu, Kaichen Lai, Ying Wang, Guoli Yang
IF：
6.1070
Publish_to：
iScience
PMID：
37250312
The maca protein ameliorates DSS-induced colitis in mice by modulating the gut microbiota and production of SCFAs
点击查看 >>
Author：
Ping He, Yizhe Zhang, Ruyang Chen, Zhaoli Tong, Mengmeng Zhang, Hui Wu
IF：
6.1000
Publish_to：
Food & Function
PMID：
37955225
HPS6 Regulates the Biogenesis of Weibel-Palade Body in Endothelial Cells Through Trafficking v-ATPase to Its Limiting Membrane
点击查看 >>
Author：
Jiran Lu, Jing Ma, Zhenhua Hao, Wei Li
IF：
6.0810
Publish_to：
Frontiers in Cell and Developmental Biology
PMID：
35252216
Rosmarinic Acid Ameliorates Pulmonary Ischemia/Reperfusion Injury by Activating the PI3K/Akt Signaling Pathway.
点击查看 >>
Author：
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
IF：
5.9880
Publish_to：
Frontiers in Pharmacology
PMID：
35645792
Lactobacillus johnsonii L531 Ameliorates Salmonella enterica Serovar Typhimurium Diarrhea by Modulating Iron Homeostasis and Oxidative Stress via the IRP2 Pathway
点击查看 >>
Author：
Keyuan Chen, Jiufeng Wang, Liang Guo, Jing Wang, Lan Yang, Ting Hu, Yiqing Zhao, Xue Wang, Yaohong Zhu
IF：
5.9000
Publish_to：
Nutrients
PMID：
36904126
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas
点击查看 >>
Author：
Li Jiabo, Wang Xuya, Chen Lulu, Zhang Jinhao, Zhang Yiming, Ren Xiao, Sun Jinzhang, Fan Xiaoguang, Fan Jikang, Li Tao, Tong Luqing, Yi Li, Chen Lei, Liu Jie, Shang Guanjie, Ren Xiude, Zhang Hao, Yu Shengping, Ming Haolang, Huang Qiang, Dong Jun, Zhang Che
IF：
5.8540
Publish_to：
CANCER GENE THERAPY
PMID：
34992215
P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation
点击查看 >>
Author：
Cheng Fangyuan, Li Mingyue, Thorne Rick Francis, Liu Guangzhi, Zhang Yuwei, Wu Mian, Liu Lianxin
IF：
5.8450
Publish_to：
STEM CELLS
PMID：
35896382
Isolation and Characterization of a Novel Cyanophage Encoding Multiple Auxiliary Metabolic Genes
点击查看 >>
Author：
Cuhuang Rong, Kun Zhou, Shuiming Li, Kang Xiao, Ying Xu, Rui Zhang, Yunlan Yang, Yu Zhang
IF：
5.8180
Publish_to：
Viruses-Basel
PMID：
35632629
The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway
点击查看 >>
Author：
Ji Ming, Zhang Zhihui, Lin Songwen, Wang Chunyang, Jin Jing, Xue Nina, Xu Heng, Chen Xiaoguang
IF：
5.8110
Publish_to：
Frontiers in Pharmacology
PMID：
34899305
Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma
点击查看 >>
Author：
Yifei Shen, Shuaishuai Xu, Chanqi Ye, Qiong Li, Ruyin Chen, Wei Wu, Qi Jiang, Yunlu Jia, Xiaochen Zhang, Longjiang Fan, Wenguang Fu, Ming Jiang, Jinzhang Chen, Michael P. Timko, Peng Zhao, Jian Ruan
IF：
5.8000
Publish_to：
iScience
PMID：
36852159
Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration
点击查看 >>
Author：
Liu, Xiaoling, Zu, Er, Chang, Xinyu, Ma, Xiaowei, Wang, Ziqi, Song, Xintong, Li, Xiangru, Yu, Qing, Kamei, Ken-ichiro, Hayashi, Toshihiko, Mizuno, Kazunori, Hattori, Shunji, Fujisaki, Hitomi, Ikejima, Takashi, Wang, Dan Ohtan
IF：
5.7580
Publish_to：
Disease Models & Mechanisms
PMID：
34821368
TOP2A correlates with poor prognosis and affects radioresistance of medulloblastoma.
点击查看 >>
Author：
Yufeng Zhang, Haiyan Yang, Liwen Wang, Huandi Zhou, Ge Zhang, Zhiqing Xiao, Xiaoying Xue
IF：
5.7380
Publish_to：
Frontiers in Oncology
PMID：
35912241
Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1
点击查看 >>
Author：
Zheng Fu, Wu Tong, Wang Feifei, Li Huazhi, Tang Hongyi, Cui Xinyu, Li Cuiying, Wang Yixiang, Jiang Jiuhui
IF：
5.7000
Publish_to：
Frontiers in Bioengineering and Biotechnology
PMID：
38694622
Endothelial LRP1-ICD Accelerates Cognition-Associated Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse Model of Parkinson’s Disease
点击查看 >>
Author：
Huang Rui, Gao Yuyuan, Duan Qingrui, Zhang Qingxi, He Peikun, Chen Jianing, Ma Guixian, Wang Limin, Zhang Yuhu, Nie Kun, Wang Lijuan
IF：
5.6820
Publish_to：
MOLECULAR NEUROBIOLOGY
PMID：
36394710
Pemetrexed ameliorates Con A-induced hepatic injury by restricting M1 macrophage activation
点击查看 >>
Author：
Zhaiyi Liu, Zhiyue Bao, Bo Yu, Lihong Chen, Guangrui Yang
IF：
5.6000
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
37925950
Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis
点击查看 >>
Author：
Shen Hong-Yu, Shi Liu-Xi, Wang Lin, Fang Le-Ping, Xu Wei, Xu Ju-Qing, Fan Bo-Qiang, Fan Wei-Fei
IF：
5.5310
Publish_to：
Journal of Translational Medicine
PMID：
34507559
Valsa mali secretes an effector protein VmEP1 to target a K homology domain-containing protein for virulence in apple
点击查看 >>
Author：
Weidong Wang, Shuaile Wang, Wan Gong, Luqiong Lv, Liangsheng Xu, Jiajun Nie, Lili Huang
IF：
5.5200
Publish_to：
MOLECULAR PLANT PATHOLOGY
PMID：
35851537
Alternative splicing of the human rhomboid family-1 gene RHBDF1 inhibits epidermal growth factor receptor activation
点击查看 >>
Author：
Renpeng Ji, Qianqian Shi, Yixin Cao, Jingyue Zhang, Cancan Zhao, Huanyu Zhao, Yasra Sayyed, Li Fu, Lu-Yuan Li
IF：
5.4860
Publish_to：
JOURNAL OF BIOLOGICAL CHEMISTRY
PMID：
35595096
A Novel Tension Machine Promotes Bone Marrow Mesenchymal Stem Cell Osteoblastic and Fibroblastic Differentiation by Applying Cyclic Tension
点击查看 >>
Author：
Yi Zhao, Yiping Huang, Lingfei Jia, Ruoxi Wang, Kuang Tan, Weiran Li
IF：
5.4430
Publish_to：
Stem Cells International
PMID：
34422062
Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3–Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury
点击查看 >>
Author：
Chengting Luo, Wenxi Ding, Changmei Yang, Wenhao Zhang, Xiaohui Liu, Haiteng Deng
IF：
5.3700
Publish_to：
JOURNAL OF PROTEOME RESEARCH
PMID：
35699728
The effects of NCBP3 on METTL3-mediated m6A RNA methylation to enhance translation process in hypoxic cardiomyocytes
点击查看 >>
Author：
Fei Ye, Xiaoyan Wang, San Tu, Lixiong Zeng, Xu Deng, Wenzhi Luo, Zhihui Zhang
IF：
5.3100
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
34382339
NAD+ metabolic enzyme inhibitor as radiosensitizer for malignant meningioma and its modulation of P53 expression
点击查看 >>
Author：
Lv Yifan, Deng Yuxuan, Feng Jie, Liu Jinqiu, Yang Mingxu, Pu Zhuonan, Zhang Shaodong, Wu Zhen, Ji Nan, Park Deric M., Hao Shuyu
IF：
5.3000
Publish_to：
MOLECULAR CANCER THERAPEUTICS
PMID：
39039948
siRNA-induced CD44 knockdown suppresses the proliferation and invasion of colorectal cancer stem cells through inhibiting epithelial–mesenchymal transition
点击查看 >>
Author：
Weiyan Zou, Yi Zhang, Guangfu Bai, Jialu Zhuang, Lin Wei, Zishu Wang, Meiqun Sun, Junbin Wang
IF：
5.2950
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
35229451
Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors
点击查看 >>
Author：
Dongjuan Si, Huijuan Luo, Xiaomeng Zhang, Kundi Yang, Hongmei Wen, Wei Li, Jian Liu
IF：
5.2750
Publish_to：
BIOORGANIC CHEMISTRY
PMID：
34426149
Upregulated Talin1 synergistically boosts β-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis
点击查看 >>
Author：
Wang Yi-yi, Duan Hua, Wang Sha, Quan Yong-jun, Huang Jun-hua, Guo Zheng-chen
IF：
5.2110
Publish_to：
Reproductive Biology and Endocrinology
PMID：
33990206
A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats
点击查看 >>
Author：
Li Yize, Zhang Linlin, Li Jing, Wang Chunyan, Chen Yi, Yuan Yuan, Xie Keliang, Wang Guolin, Yu Yonghao
IF：
5.2030
Publish_to：
Neuroscience Bulletin
PMID：
33779892
CUDC 101 is a potential target inhibitor for the EGFR overexpression bladder cancer cells
点击查看 >>
Author：
Zhenxing Wang, Lanxin Li, Chunhong Chu, Xiangkai Wei, Qian Liu, Rui Wang, Guoliang Zhang, Guangyao Wu, Ying Wang, Lei An, Xiaodong Li
IF：
5.2000
Publish_to：
INTERNATIONAL JOURNAL OF ONCOLOGY
PMID：
37830158
Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo
点击查看 >>
Author：
Qian-Wen Kong, Jiao Yang, Dan Li, Ya-Wei Ding, Yu-Jie Hu, Xiao-Chuan Xue, Mei-Zhi Shi, Bo Jiang, Yang-Yun Zhou, Min Zhang, Jiu-Dong Hu, Cheng Guo, Jun-Jun Chen, Yong-Long Han
IF：
5.1950
Publish_to：
JOURNAL OF ETHNOPHARMACOLOGY
PMID：
36126783
Compressive force-induced LincRNA-p21 inhibits mineralization of cementoblasts by impeding autophagy
点击查看 >>
Author：
Hao Liu, Yiping Huang, Yuhui Yang, Yineng Han, Lingfei Jia, Weiran Li
IF：
5.1920
Publish_to：
FASEB JOURNAL
PMID：
34958157
TH5487, a small molecule inhibitor of OGG1, attenuates pulmonary fibrosis by NEDD4L-mediated OGG1 degradation
点击查看 >>
Author：
Huayu Ling, Chuge Song, Yaowei Fang, Yu Yin, Zijun Wu, Yahong Wang, Zhiliang Xu, Shenglan Gao, Ao Li, Gang Liu
IF：
5.1680
Publish_to：
CHEMICO-BIOLOGICAL INTERACTIONS
PMID：
35654123
Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell viability
点击查看 >>
Author：
Sai Shi, Biao Ma, Fude Sun, Chang Qu, Hailong An
IF：
5.1570
Publish_to：
JOURNAL OF BIOLOGICAL CHEMISTRY
PMID：
34329684
Farrerol Alleviates Cerebral Ischemia–Reperfusion Injury by Promoting Neuronal Survival and Reducing Neuroinflammation
点击查看 >>
Author：
Zhao Rui, Zhou Xin, Zhao Zhiyuan, Liu Wenhao, Lv Mengfei, Zhang Zhaolong, Wang Changxin, Li Tianli, Yang Zixiong, Wan Qi, Xu Rui, Cui Yu
IF：
5.1000
Publish_to：
MOLECULAR NEUROBIOLOGY
PMID：
38376762
Renal tubule ectopic lipid deposition in diabetic kidney disease rat model and in vitro mechanism of leptin intervention
点击查看 >>
Author：
Liu Shasha, Da Jingjing, Yu Jiali, Dong Rong, Yuan Jing, Yu Fuxun, Zha Yan
IF：
5.0800
Publish_to：
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
PMID：
35192189
Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells
点击查看 >>
Author：
Tianjie Wang, Hongyu Lei, Lihua Zhou, Meiwen Tang, Qing Liu, Feng Long, Qing Li, Jianming Su
IF：
5.0750
Publish_to：
Toxins
PMID：
35878209
PCP Protein Inversin Regulates Testis Function Through Changes in Cytoskeletal Organization of Actin and Microtubules
点击查看 >>
Author：
Li Linxi, Gao Sheng, Wang Lingling, Bu Tiao, Chu Jinjin, Lv Lixiu, Tahir Anam, Mao Baiping, Li Huitao, Li Xiaoheng, Wang Yiyan, Wu Xiaolong, Ge Renshan, Cheng C Yan
IF：
5.0510
Publish_to：
ENDOCRINOLOGY
PMID：
35106541
Bioactive Scaffold Fabricated by 3D Printing for Enhancing Osteoporotic Bone Regeneration
点击查看 >>
Author：
Xiaoting Zhang, Xinluan Wang, Yuk-wai Lee, Lu Feng, Bin Wang, Qi Pan, Xiangbo Meng, Huijuan Cao, Linlong Li, Haixing Wang, Shanshan Bai, Lingchi Kong, Dick Ho Kiu Chow, Ling Qin, Liao Cui, Sien Lin, Gang Li
IF：
5.0460
Publish_to：
Bioengineering-Basel
PMID：
36290493
Deficiency of smooth muscle cell ILF3 alleviates intimal hyperplasia via HMGB1 mRNA degradation-mediated regulation of the STAT3/DUSP16 axis
点击查看 >>
Author：
Ya-min Hou, Bo-han Xu, Qiu-ting Zhang, Jie Cheng, Xu Zhang, Hong-rui Yang, Ze-ying Wang, Peng Wang, Ming-xiang Zhang
IF：
5.0000
Publish_to：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
PMID：
38583797
Inhibition of p38 mitogen-activated protein kinases may attenuate scar proliferation after cleft lip surgery in rabbits via Smads signaling pathway
点击查看 >>
Author：
Ding Qian, Yue Jin, Xue Ling-fa, Xu Yao-xiang, Xiao Wen-lin
IF：
4.9810
Publish_to：
EUROPEAN JOURNAL OF MEDICAL RESEARCH
PMID：
35858881
Verification of the role of spiperone in the treatment of COPD through bioinformatics analysis
点击查看 >>
Author：
Donglan Zhu, Nan Ma, Lin Chen, Jinfu Huang, Xiaoning Zhong
IF：
4.9320
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
34741870
Revealing the Role of Beesioside O from Actaea vaginata for the Treatment of Breast Cancer Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
点击查看 >>
Author：
Shuyang Li, Juan Lu, Hongwei Xue, Yang Lou, Jia Liu, Yutian Wang, Haifeng Wu, Xi Chen
IF：
4.9000
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
40076902
Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6
点击查看 >>
Author：
Huan Yi, Yan-zhao Su, Rong Lin, Xiang-qin Zheng, Diling Pan, Dan-mei Lin, Xiang Gao, Rong Zhang
IF：
4.8180
Publish_to：
Journal of Immunology Research
PMID：
33855091
FTO-mediated m6A modification of serum amyloid A2 mRNA promotes podocyte injury and inflammation by activating the NF-κB signaling pathway
点击查看 >>
Author：
Yating Lang, Qimeng Wang, Qinghao Sheng, Shangwei Lu, Meilin Yang, Zhijuan Kong, Ying Gao, Xiaoting Fan, Ning Shen, Rong Wang, Zhimei Lv
IF：
4.8000
Publish_to：
FASEB JOURNAL
PMID：
38193628
Loss of Cep72 affects the morphology of spermatozoa in mice.
点击查看 >>
Author：
Zhen Chen, Yating Xu, Dupeng Ma, Changrong Li, Ziqi Yu, Cong Liu, Tingyu Jin, Ziye Du, Zejia Li, Qi Sun, Yumin Xu, Rong Liu, Yuerong Wu, Mengcheng Luo
IF：
4.7550
Publish_to：
Frontiers in Physiology
PMID：
36277211
Targeting STT3A produces an anti-tumor effect in lung adenocarcinoma by blocking the MAPK and PI3K/AKT signaling pathway
点击查看 >>
Author：
Jiahan Cheng, Liang Xia, Xiaohu Hao, Fanyi Gan, Yuquan Bai, Chuanfen Zhang, Yonghong Mao, Yunke Zhu, Qiang Pu, Dong Won Park, Simona Tavolari, Jiandong Mei, Yaohui Chen, Senyi Deng, Lunxu Liu
IF：
4.7260
Publish_to：
Translational Lung Cancer Research
PMID：
35832442
Enhancement of β-Caryophyllene Biosynthesis in Saccharomyces cerevisiae via Synergistic Evolution of β-Caryophyllene Synthase and Engineering the Chassis
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Author：
Surui Lu, Hong Deng, Chenyao Zhou, Zhengda Du, Xuena Guo, Yanfei Cheng, Xiuping He
IF：
4.7000
Publish_to：
ACS Synthetic Biology
PMID：
37224386
Identification and functional analysis of LncRNA-XIST ceRNA network in prostate cancer
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Author：
Wang Jie, Huang Jie, Guo Yingxue, Fu Yuli, Cao Yifang, Zhou Kang, Ma Jianxiong, Lv Bodong, Huang Wenjie
IF：
4.6380
Publish_to：
BMC CANCER
PMID：
36038831
YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer
点击查看 >>
Author：
Yang Zhao, Hongchao Zhao, Danhuan Zhang, Qiuying Quan, Yan Ge, Liantao Li, Lingchuan Guo
IF：
4.6340
Publish_to：
ACS Chemical Biology
PMID：
35708211
Synthetic flavagline derivative 1-chloroacetylrocaglaol promotes apoptosis in K562 erythroleukemia cells through miR-17-92 cluster genes
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Author：
Xijun Wu, Xinmei Yang, Krishnapriya M. Varier, Qing Rao, Jingrui Song, Lei Huang, Yubing Huang, Babu Gajendran, Zhixu He, Chunmao Yuan, Yanmei Li
IF：
4.6130
Publish_to：
ARCHIV DER PHARMAZIE
PMID：
36216575
Translatomics reveals the role of dietary calcium addition in regulating muscle fat deposition in pigs
点击查看 >>
Author：
Yu Jingsu, Li Xiangling, Qi Xinyu, Ding Zhaoxuan, Su Songtao, Yu Lin, Zhou Lei, Li Yixing
IF：
4.6000
Publish_to：
Scientific Reports
PMID：
38811812
Downregulated F-Box/LRR-Repeat Protein 7 Facilitates Pancreatic Cancer Metastasis by Regulating Snail1 for Proteasomal Degradation
点击查看 >>
Author：
Tang Liang, Ji Meng, Liang Xing, Chen Danlei, Liu Anan, Yang Guang, Shi Ligang, Fu Zhiping, Shao Chenghao
IF：
4.5990
Publish_to：
Frontiers in Genetics
PMID：
34249081
Umbilical cord mesenchymal stem cell-derived exosomes reverse endometrial fibrosis by the miR-145-5p/ZEB2 axis in intrauterine adhesions
点击查看 >>
Author：
Xiao Li, Hua Duan, Sha Wang, Cheng-Xiao Lv
IF：
4.5670
Publish_to：
REPRODUCTIVE BIOMEDICINE ONLINE
PMID：
36567149
Fumonisin B1 Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells
点击查看 >>
Author：
Qing Li, Qiaoling Yuan, Tianjie Wang, Yang Zhan, Lingchen Yang, Ying Fan, Hongyu Lei, Jianming Su
IF：
4.5460
Publish_to：
Toxins
PMID：
34941701
Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma
点击查看 >>
Author：
Hao Wang, Zhinan Liu, Zhuo Sun, Dong Zhou, Hanyan Mao, Guohua Deng
IF：
4.5340
Publish_to：
CELL CYCLE
PMID：
34470581
Serum Exosomal Long Noncoding RNA Growth Arrest-Specific 5 Predicts 3-Month Mortality in Acute-on-Chronic Hepatitis B Liver Failure
点击查看 >>
Author：
Cheng-Xi Sun, Li-Yan Han, Kai Wang, Shuai Gao
IF：
4.5000
Publish_to：
Journal of Inflammation Research
PMID：
37868833
Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure
点击查看 >>
Author：
Shuai Gao, Yu-Chen Fan, Li-Yan Han, Kai Wang
IF：
4.4730
Publish_to：
Expert Review of Clinical Immunology
PMID：
34057878
Crocin induces ROS-mediated papillary thyroid cancer cell apoptosis by modulating the miR-34a-5p/PTPN4 axis in vitro
点击查看 >>
Author：
Yan Tang, Han Yang, Jinsong Yu, Zhong Li, Quanxiao Xu, Bo Ding, Guangwei Jia
IF：
4.4600
Publish_to：
TOXICOLOGY AND APPLIED PHARMACOLOGY
PMID：
35085590
Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway
点击查看 >>
Author：
Yingchao Gong, Qingfeng Li, Zetao Ma, Tingting Jin, Jun Lin, Qingbo Lv, Meihui Wang, Guosheng Fu, Shengjie Xu
IF：
4.4320
Publish_to：
EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：
34582847
Antimicrobial peptide temporin-1CEa isolated from frog skin secretions inhibits the proinflammatory response in lipopolysaccharide-stimulated RAW264.7 murine macrophages through the MyD88-dependent signaling pathway
点击查看 >>
Author：
Juan Zhang, Yue Sun, Yao Kang, Dejing Shang
IF：
4.4070
Publish_to：
MOLECULAR IMMUNOLOGY
PMID：
33494936
Effector protein Hcp2a of avian pathogenic Escherichia coli interacts with the endoplasmatic reticulum associated RPL23 protein of chicken DF-1 fibroblasts
点击查看 >>
Author：
Chen Zhe, Qi Zhao, Li Ziqi, Song Zichao, Wang Xiaoru, Shao Ying, Tu Jian, Song Xiangjun
IF：
4.4000
Publish_to：
VETERINARY RESEARCH
PMID：
36717947
Metabotropic Glutamate Receptor 8 Is Regulated by miR-33a-5p and Functions as an Oncogene in Breast Cancer
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Author：
Chunxu Zhang, Shuang Xie, Shouxin Yuan, Yuanhao Zhang, Yunhu Bai, Lijia Chu, Zuyin Wu, Ninghui Guo, Quanhui Wang, Jixin Zhang
IF：
4.3750
Publish_to：
Journal of Oncology
PMID：
34950209
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics
点击查看 >>
Author：
Yan Li, Cuiyu Li, Yuhua Xiong, Bin Fang, Xing Lin, Quanfang Huang
IF：
4.3190
Publish_to：
Drug Design Development and Therapy
PMID：
35698653
TRPM2 knockdown attenuates myocardial apoptosis and promotes autophagy in HFD/STZ-induced diabetic mice via regulating the MEK/ERK and mTORC1 signaling pathway
点击查看 >>
Author：
Hu Feng, Lin Chaoyang
IF：
4.3000
Publish_to：
MOLECULAR AND CELLULAR BIOCHEMISTRY
PMID：
38308007
Cystic fibrosis transmembrane conductance regulator-associated ligand protects dopaminergic neurons by differentially regulating metabotropic glutamate receptor 5 in the progression of neurotoxin 6-hydroxydopamine-induced Parkinson's disease model
点击查看 >>
Author：
Yuan Wang, Li Gu, Hui Min Yang, Hong Zhang
IF：
4.2940
Publish_to：
NEUROTOXICOLOGY
PMID：
33571554
Circular RNA hsa_circ_0032463 Acts as the Tumor Promoter in Osteosarcoma by Regulating the MicroRNA 498/LEF1 Axis
点击查看 >>
Author：
Guanghua Qin, Xuejian Wu
IF：
4.2720
Publish_to：
MOLECULAR AND CELLULAR BIOLOGY
PMID：
34096776
LINC01296/miR-141-3p/ZEB1-ZEB2 axis promotes tumor metastasis via enhancing epithelial-mesenchymal transition process
点击查看 >>
Author：
Zhenqiang Sun, Bo Shao, Zaoqu Liu, Qin Dang, Yaxin Guo, Chen Chen, Yuying Guo, Zhuang Chen, Jinbo Liu, Shengyun Hu, Weitang Yuan, Quanbo Zhou
IF：
4.2070
Publish_to：
Journal of Cancer
PMID：
33854632
miR‑27a‑3p upregulation by p65 facilitates cervical tumorigenesis by increasing TAB3 expression and is involved in the positive feedback loop of NF‑κB signaling
点击查看 >>
Author：
Min Li, Zixuan Gao, Shuo Wang, Yungang Zhao, Hong Xie
IF：
4.2000
Publish_to：
ONCOLOGY REPORTS
PMID：
37203408
Anti-inflammation and adhesion enhancement properties of the multifunctional LPxTG-motif surface protein derived from the Lactobacillus reuteri DSM 8533
点击查看 >>
Author：
Hai Xu, Lifeng Lao, Chunyu Ji, Qianqian Lu, Yuxing Guo, Daodong Pan, Zhen Wu
IF：
4.1740
Publish_to：
MOLECULAR IMMUNOLOGY
PMID：
35421739
HOXA10 improves endometrial receptivity by upregulating E-cadherin
点击查看 >>
Author：
Bi Yin, Huang Weiyu, Yuan Lifang, Chen Saiqiong, Liao Shengbin, Fu Xiaoqian, Liu Bo, Yang Yihua
IF：
4.1610
Publish_to：
BIOLOGY OF REPRODUCTION
PMID：
35044439
p38MAPK silencing attenuates scar proliferation after cleft palate repair surgery in rats via MRTF-A/SRF pathway
点击查看 >>
Author：
Qian Ding, Gong-jun Wang, Ling-fa Xue, Jin Yue, Yao-xiang Xu, Zhen-zhen Fu, Wen-lin Xiao
IF：
4.1450
Publish_to：
EXPERIMENTAL CELL RESEARCH
PMID：
35690133
FNDC5 Promotes Adipogenic Differentiation of Primary Preadipocytes in Mashen Pigs
点击查看 >>
Author：
Wei Hei, Ziwei You, Jiaqi An, Tianzhi Zhao, Jiao Li, Wanfeng Zhang, Meng Li, Yang Yang, Pengfei Gao, Guoqing Cao, Xiaohong Guo, Chunbo Cai, Bugao Li
IF：
4.1410
Publish_to：
Genes
PMID：
36672836
Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152
点击查看 >>
Author：
Junjie Yang, Yong Ying, Xiangtai Zeng, Jiafeng Liu, Yang Xie, Zefu Deng, Zhiqiang Hu, Zanbin Li
IF：
4.1330
Publish_to：
Analytical Cellular Pathology
PMID：
35592867
Corrigendum: HAX-1 Protects Glioblastoma Cells From Apoptosis Through the Akt1 Pathway
点击查看 >>
Author：
Xin Deng, Laijun Song, Wen Zhao, Ying Wei and Xin-
IF：
4.0000
Publish_to：
CORRECTION ARTICLE
PMID：
30766479
Characterization of comprehensive dynamic epigenetic changes during human primary Sjögren’s syndrome progression
点击查看 >>
Author：
Ningning Cao, Huan Shi, Chan Chen, Lisong Xie, Zhijun Wang, Lingyan Zheng, Chuangqi Yu
IF：
3.9320
Publish_to：
Annals of Translational Medicine
PMID：
34422956
AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization
点击查看 >>
Author：
Xingjie Chen, Yalin Lu, Gaochao Guo, Yu Zhang, Yan Sun, Lianmei Guo, Ruohong Li, Yang Nan, Xuejun Yang, Jun Dong, Xun Jin, Qiang Huang
IF：
3.9060
Publish_to：
ONCOLOGY REPORTS
PMID：
34036399
Ginger inhibits the invasion of ovarian cancer cells SKOV3 through CLDN7, CLDN11 and CD274 m6A methylation modifications
点击查看 >>
Author：
Zhang Xiaoyu, Zhang Hairong, Zhu Lin, Xia Lei
IF：
3.9000
Publish_to：
BMC Complementary Medicine and Therapies
PMID：
38575994
CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells
点击查看 >>
Author：
Xie Bei, Zhao Lei, Zhang Zhewen, Zhou Cunmin, Tian Ye, Kang Yingying, Chen Jing, Wei Hulai, Li Linjing
IF：
3.8000
Publish_to：
BMC CANCER
PMID：
37814227
HEY1-mediated cisplatin resistance in lung adenocarcinoma via epithelial–mesenchymal transition
点击查看 >>
Author：
Gao Jin, Li Yadong, Zou Xiaoteng, Lei Tianyao, Xu Tianwei, Chen Yijiang, Wang Zhaoxia
IF：
3.7380
Publish_to：
MEDICAL ONCOLOGY
PMID：
36396748
Xinnaotongluo liquid protects H9c2 cells from H/R-induced damage by regulating MDM2/STEAP3
点击查看 >>
Author：
Jiankun Cui, Qinwen Wang, Minghao Li
IF：
3.7000
Publish_to：
PLoS One
PMID：
38640125
Activation of translocator protein alleviates mechanical allodynia and bladder dysfunction in cyclophosphamide-induced cystitis through repression of BDNF-mediated neuroinflammation
点击查看 >>
Author：
Yong Huang, Minzhi Su, Chi Zhang, Hailun Zhan, Fei Yang, Zhentao Gao, Xiangfu Zhou, Bolong Liu
IF：
3.6510
Publish_to：
EUROPEAN JOURNAL OF PAIN
PMID：
35293071
Ginger and 6-gingerol prevent lipopolysaccharide-induced intestinal barrier damage and liver injury in mice
点击查看 >>
Author：
Xiao-Xuan Guo, Yun-Dan Zhang, Tian-Cai Wang, Xin-Lu Wang, Yan-Yang Xu, Yong Wang, Jing Qiu
IF：
3.6390
Publish_to：
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
PMID：
34309869
Krüppel-like factor 5 promotes the progression of oral squamous cell carcinoma via the baculoviral IAP repeat containing 5 gene.
点击查看 >>
Author：
Yuehua Li, Wen Shi, Yajun Shen, Li Xu, Zhigang Cai, Xiaofeng Shan
IF：
3.6160
Publish_to：
Annals of Translational Medicine
PMID：
36267746
Bisdemethoxycurcumin suppresses the progression of atherosclerosis and VSMC-derived foam cell formation by promoting lipophagy
点击查看 >>
Author：
Zuo Jiangwei, Guo Sien, Qin Xiao
IF：
3.6000
Publish_to：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
PMID：
37289282
Catalpol Weakens Depressive-like Behavior in Mice with Streptozotocin-induced Hyperglycemia via PI3K/AKT/Nrf2/HO-1 Signaling Pathway
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Author：
Xiaohui Wu, Junming Wang, Lingling Song, Yuechen Guan, Can Cao, Ying Cui, Yueyue Zhang, Chen Liu
IF：
3.5900
Publish_to：
NEUROSCIENCE
PMID：
34358633
COL3A1 Overexpression Associates with Poor Prognosis and Cisplatin Resistance in Lung Cancer
点击查看 >>
Author：
Lihuai Wang, Yinhui Sun, Zhongcong Guo, Hua Liu
IF：
3.5700
Publish_to：
Balkan Medical Journal
PMID：
36148899
COL10A1 is a novel factor in the development of choroidal neovascularization
点击查看 >>
Author：
Da Lv, Donglong Chen, Zhijie Wang, Zekai Cui, Jacey Hongjie Ma, Shangli Ji, Jiansu Chen, Shibo Tang
IF：
3.5140
Publish_to：
MICROVASCULAR RESEARCH
PMID：
34520774
Uncoupling Protein 3 Promotes the Myogenic Differentiation of Type IIb Myotubes in C2C12 Cells
点击查看 >>
Author：
Ziwei You, Jieyu Wang, Faliang Li, Wei Hei, Meng Li, Xiaohong Guo, Pengfei Gao, Guoqing Cao, Chunbo Cai, Bugao Li
IF：
3.5000
Publish_to：
Genes
PMID：
38002992
Repair of Spinal Cord Injury by Inhibition of PLK4 Expression Through Local Delivery of siRNA-Loaded Nanoparticles
点击查看 >>
Author：
Gu Yingchu, Zhang Runze, Jiang Bin, Xu Xin, Guan Jun Jie, Jiang Xing Jie, Zhou Yuan, Zhou You Lang, Chen Xiangdong
IF：
3.4440
Publish_to：
JOURNAL OF MOLECULAR NEUROSCIENCE
PMID：
34471984
PI3K/AKT pathway promotes keloid fibroblasts proliferation by enhancing glycolysis under hypoxia
点击查看 >>
Author：
Qifei Wang, Xin Yang, Jianxun Ma, Xiang Xie, Yimou Sun, Xu Chang, Hongsen Bi, Hongyu Xue, Zelian Qin
IF：
3.4010
Publish_to：
WOUND REPAIR AND REGENERATION
PMID：
36571288
TGF-β2-induced alterations of m6A methylation in hTERT RPE-1 cells
点击查看 >>
Author：
Xue Li, Xueru Zhao, Ruijie Yin, Min Yuan, Yongya Zhang, Xiaohua Li
IF：
3.4000
Publish_to：
EXPERIMENTAL EYE RESEARCH
PMID：
38395214
Astragaloside IV attenuates high glucose-induced human keratinocytes injury via TGF-β/Smad signaling pathway
点击查看 >>
Author：
Qiong Gao, Li Pan, Yi Li, Xuanfen Zhang
IF：
3.3740
Publish_to：
Journal of Tissue Viability
PMID：
36028386
Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6
点击查看 >>
Author：
Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu, Baoshan Wang
IF：
3.3000
Publish_to：
CELL TRANSPLANTATION
PMID：
36852700
PM2.5 activated NLRP3 inflammasome and IL-1β release in MH-S cells by facilitating autophagy via activating Wnt5a
点击查看 >>
Author：
Guanli Yuan, Yinfeng Liu, Zheng Wang, Xiaotong Wang, Zhuoxiao Han, Xixin Yan, Aihong Meng
IF：
3.2980
Publish_to：
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
PMID：
36347039
PITX2 regulates steroidogenesis in granulosa cells of dairy goat by the WNT/β-catenin pathway
点击查看 >>
Author：
Qiqi Bu, Shujuan Liu, Zhanhang Wang, Jiahao Zou, Peijie Wang, Heran Cao, Dexian Li, Binyun Cao, Xiaopeng An, Yuxuan Song, Guang Li
IF：
3.2550
Publish_to：
GENERAL AND COMPARATIVE ENDOCRINOLOGY
PMID：
35300988
MiR-7a-5p Attenuates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Targeting VDAC1
点击查看 >>
Author：
Lu Hailin, Zhang Jiangfeng, Xuan Feifei
IF：
3.2390
Publish_to：
Cardiovascular Toxicology
PMID：
34661851
Sulfur Amino Acid Metabolism and the Role of Endogenous Cystathionine-γ-lyase/H2S in Holstein Cows with Clinical Mastitis
点击查看 >>
Author：
Bohao Zhang, Ting Lin, Xu Bai, Xiaoxiao An, Lijun Dai, Jun Shi, Yong Zhang, Xingxu Zhao, Quanwei Zhang
IF：
3.2310
Publish_to：
Animals
PMID：
35681915
Matrine inhibits the Wnt3a/β-catenin/TCF7L2 signaling pathway in experimental autoimmune encephalomyelitis
点击查看 >>
Author：
Rui Ma, Yaojuan Chu, Mengmeng Dou, Yilei Jing, Xiaoyu Zhao, Xinyu Li, Silu Li, Yuan Zhang, Limei Wang, Lin Zhu
IF：
3.2210
Publish_to：
JOURNAL OF NEUROIMMUNOLOGY
PMID：
35489221
Recombinant protein EBI3 attenuates Clonorchis sinensis-induced liver fibrosis by inhibiting hepatic stellate cell activation in mice
点击查看 >>
Author：
Zhao Lei, Li Jia, Mo Gang, Cao Deping, Li Chun, Huang Guoyang, Jiang Liping, Chen Gen, Yao Hongbing, Peng Xiaohong
IF：
3.2000
Publish_to：
Parasites & Vectors
PMID：
37480105
Liver cancer cells as the model for developing liver-targeted RNAi therapeutics
点击查看 >>
Author：
Beibei Hou, Linhui Qin, Linfeng Huang
IF：
3.1000
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
36640667
Talin1 Induces Epithelial-Mesenchymal Transition to Facilitate Endometrial Cell Migration and Invasion in Adenomyosis Under the Regulation of microRNA-145-5p
点击查看 >>
Author：
Wang Yi-yi, Duan Hua, Wang Sha, Quan Yong-jun, Huang Jun-hua, Guo Zheng-chen
IF：
3.0600
Publish_to：
Reproductive Sciences
PMID：
33537874
Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity
点击查看 >>
Author：
Yilei Jing, Rui Ma, Yaojuan Chu, Mengmeng Dou, Mengru Wang, Xinyu Li, Lin Zhu
IF：
3.0520
Publish_to：
JOURNAL OF CHEMICAL NEUROANATOMY
PMID：
34280490
Circ_0001714 knockdown alleviates lipopolysaccharide-induced apoptosis and inflammation in renal tubular epithelial cells via miR-129-5p/TRAF6 axis in septic acute kidney injury
点击查看 >>
Author：
Tan Yiqing, Yu Ziying, Li Pei, Liu Yu, You Ting, Kuang Feng, Luo Wei
IF：
3.0000
Publish_to：
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
PMID：
37526815
Knockdown of ETV4 promotes autophagy‑dependent apoptosis in GBM cells by reducing the transcriptional activation of EMP1
点击查看 >>
Author：
Junxiang Wang, Chengfa Sun, Jian Li, Hua Jiang, Yun Qiu, Mingjie Gong
IF：
2.9670
Publish_to：
Oncology Letters
PMID：
34976153
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway
点击查看 >>
Author：
Wei Jinmei, Chen Yan, Feng Tingmei, Wei Yuihui, Yang Caizhen, Zhang Changwen, Li Wentao, Liu Guangnan
IF：
2.9000
Publish_to：
FUNCTIONAL & INTEGRATIVE GENOMICS
PMID：
38374244
Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis
点击查看 >>
Author：
Chengbin Wang, Pingfeng Zhang, Yanni Li, Xiong Wang, Lingzhi Guo, Jingluan Li, Huihui Jiao
IF：
2.8000
Publish_to：
JOURNAL OF CHEMICAL NEUROANATOMY
PMID：
36796734
Antigen retrieval pre-treatment causes a different expression pattern of Cav3.2 in rat and mouse spinal dorsal horn
点击查看 >>
Author：
Xiao E Cheng, Long Xian Ma, Xiao Jin Feng,Meng Ye
IF：
2.7020
Publish_to：
Life sciences
PMID：
30678436
Ghrelin alleviates inflammation and pyroptosis by inhibiting TNF-α /caspase-8/caspase-3/ GSDME signalling pathways in an in vitro model of high glucose induced liver injury
点击查看 >>
Author：
Jingwen Gao, Xinrui Wang, Shengying Ye, Yixin Zhang, Yan Qin
IF：
2.7000
Publish_to：
TISSUE & CELL
PMID：
39721419
Mechanism Investigation of Wuwei Shexiang Pills on Gouty Arthritis via Network Pharmacology, Molecule Docking, and Pharmacological Verification
点击查看 >>
Author：
Jirui Lang, Li Li, Shilong Chen, Yunyun Quan, Jing Yi, Jin Zeng, Yong Li, Junning Zhao, Zhujun Yin
IF：
2.6500
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
36248423
TMAO promotes dementia progression by mediating the PI3K/Akt/mTOR pathway
点击查看 >>
Author：
Xiaojuan Hu, Yamin Zhang, Cheng Gu, Ruipeng Wu, Yuping Yao, Fulin Gao, Lulu Luo, Yi Zhang
IF：
2.6000
Publish_to：
TISSUE & CELL
PMID：
36753814
Effects of BAMBI on luteinized follicular granulosa cell proliferation and steroid hormone production in sheep
点击查看 >>
Author：
Yaqi Zhang, Zeyuan Guo, Zhangsheng Du, Zhichao Yao, Tong Guo, Yin Cheng, Kai Wang, Xiaoyan Ma, Chunlu Chen, Ermias Kebreab, Dong Wang, Lihua Lyu
IF：
2.5000
Publish_to：
MOLECULAR REPRODUCTION AND DEVELOPMENT
PMID：
36775976
Detection of mitochondrial coupling factor 6 in placental tissues from preeclamptic pregnancies and its influence on biological behavior of trophoblast cells
点击查看 >>
Author：
Wanyu Song, Xufeng Shi, Kan Liu, Ranhong Li, Leilei Niu, Lijun Su, Haiying Wu
IF：
2.4470
Publish_to：
Experimental and Therapeutic Medicine
PMID：
34475975
MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts
点击查看 >>
Author：
Wei Shuyi, Qiu Ye
IF：
2.4060
Publish_to：
3 Biotech
PMID：
33968586
ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction
点击查看 >>
Author：
Chuanmei Qin, Jiayi Wu, Xiaowei Wei, Xueqing Liu, Yi Lin
IF：
2.3000
Publish_to：
PeerJ
PMID：
39434797
Hsa_circ_0014879 regulates the radiosensitivity of esophageal squamous cell carcinoma through miR-519-3p/CDC25A axis
点击查看 >>
Author：
Liu Zihao, Lu Xiyan, Wen Linchun, You Chuanwen, Jin Xiaowei, Liu Jingying
IF：
2.2480
Publish_to：
ANTI-CANCER DRUGS
PMID：
34407051
The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway
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Author：
Xu Jiazhi, Wu Haiwei, Sun Jiatong, Gong Zhiyuan, Lu Xiaoya, Yang Enli, Chen Zhanwei, Huang Shengyun, Nong Xiaolin, Zhang Dongsheng
IF：
2.2460
Publish_to：
Head & Face Medicine
PMID：
35524269
SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma
点击查看 >>
Author：
Liqiao Chen, Liangliang Wang, Zongqi Han, Peng Qin, Guangxu Niu, Jingxia Du
IF：
2.2000
Publish_to：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
PMID：
38123304
PTX3 impairs granulosa cell function by promoting the secretion of inflammatory cytokines in M1 macrophages via the JAK pathway
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Author：
Ying Chen, Xiaofang Luo, Yizhe Li, Linhong Liu, Zhen Liu, Yunyue Tan, Ying Chen
IF：
2.1000
Publish_to：
STEROIDS
PMID：
39577792
PTB Regulates Keloid Fibroblast Migration and Proliferation Through Autophagy
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Author：
Huang Rong, Han Bing, Peng Jianzhong, Jiao Hu
IF：
2.0000
Publish_to：
AESTHETIC PLASTIC SURGERY
PMID：
39402202
LSP1 promotes the progression of acute myelogenous leukemia by regulating KSR/ERK signaling pathway and cell migration
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Author：
Tan Li, Xiaochen Gui, Bin Li, Xueying Hu, Yuanyin Wang
IF：
1.9000
Publish_to：
Hematology
PMID：
38511641
miR-301a inhibits adipogenic differentiation of adipose-derived stromal vascular fractions by targeting HOXC8 in sheep
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Author：
Bishi Zhao, Yangyang Pan, Liying Qiao, Jianhua Liu, Kaijie Yang, Yu Liang, Wenzhong Liu
IF：
1.7490
Publish_to：
ANIMAL SCIENCE JOURNAL
PMID：
34856652
Sophora flavescens alcohol extract ameliorates insomnia and promotes PI3K/AKT/BDNF signaling transduction in insomnia model rats
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Author：
Wu Yanyan, Yao Chenhang, Zhang Lan, Wu Guoqing
IF：
1.7000
Publish_to：
NEUROREPORT
PMID：
38407863
A novel animal model of induced breast precancerous lesion in tree shrew
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Author：
Maojian Chen, Chao Ou, Chun Yang, Weiping Yang, Qi
IF：
1.6940
Publish_to：
Biological and Pharmaceutical Bulletin
PMID：
30674757
PEDF relieves kidney injury in type 2 diabetic nephropathy mice by reducing macrophage infiltration
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Author：
Li Li Lan Zhang Danyan Chen Keping Yu Hua Gan Gangyi Yang
IF：
1.5820
Publish_to：
Endokrynologia Polska
PMID：
34647607
Clenbuterol Prevents Mechanical Unloading-Induced Myocardial Atrophy via Upregulation of Transient Receptor Potential Channel-3
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Author：
Dan Hu, Huadong Li, Hong Yu, Meng Zhao, Lei Ye, Baoqing Liu, Nana Ge, Nianguo Dong, Long Wu
IF：
1.5000
Publish_to：
International Heart Journal
PMID：
37778993
Polydopamine-functionalized nanohydroxyapatite coated exosomes with enhanced cytocompatibility and osteogenesis for bone regeneration
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Author：
Mingli Xiang, Gengchao Zhang, Yulin Liu, Chengcheng Liao, Linlin Xiao, Meiling Xiang, Xiaoyan Guan, Jianguo Liu
IF：
1.0000
Publish_to：
BIO-MEDICAL MATERIALS AND ENGINEERING
PMID：
39973215
技术问答
（6）
注意：
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。
京公网安备 11011202000391号
稀释后保存在冰箱会影响抑制剂功能吗？稀释后可以使用多久呢?2023-05-29 14:58:27
您好，蛋白酶抑制剂使用时,根据裂解液的用量加入蛋白酶抑制剂混合液(100×PIC)，使其终浓度达到1×，直接用于提蛋白，不建议提前稀释。
适用于裂解液的类型是什么？以及适用于的蛋白提取种类有哪些?2023-05-06 11:46:38
您好，本品为不含EDTA的蛋白酶抑制剂混合物，适用于动物哺乳动物、细胞中提取蛋白，提取出来的蛋白可用于WB,IP等实验中，常见的ripa裂解液可以添加本品。
请问是否还有NaN3成分（抑制HRP活性）?2023-02-28 17:43:30
您好，本品不含NaN3。
请问能否加在培养基里面？我是做分泌蛋白表达的。?2022-10-13 20:10:10
您好，该产品适用于从哺乳动物组织、细胞中提取蛋白质，能够更有效的获得目的蛋白质，是否可以加在培养基里还没有进行验证过，需要根据实验目的要求查阅相关文献进行确定。
您好，PIC可以抑制磷酸化蛋白去磷酸化吗?2022-09-20 14:08:49
您好，不能够抑制磷酸酶活性，抑制磷酸化蛋白去磷酸化需再添加磷酸酶抑制剂。