| CAS |
No.42895-58-9 |
| 中文名称 |
14-去氧-11，12-二去氢穿心莲内酯 |
| 英文名称 |
14-Deoxy-11，12-didehydroandrographolide |
| 分子式 |
C20H28O4 |
| 分子量 |
332.43 |
| 溶解性 |
Soluble in DMSO ≥10mg/mL |
| 纯度 |
HPLC≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| 运输条件 |
冷藏运输 |
| 靶点 |
NF-κB |
| 通路 |
NF-κB |
| 背景说明 |
是 Andrographolide 的类似物，能够抑制 NF-κB 活性。 |
| 生物活性 |
14-Deoxy-11，12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11，12-didehydroandrographolide inhibits NF-κB activation.[1] |
| In Vitro |
14-deoxy-11，12-didehydroandrographolide， a naturally occurring noncytotoxic analogue of Andrographolide， effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid， IL-4， IL-5， IL-13， and eotaxin production， serum IgE synthesis， pulmonary eosinophilia， mucus hypersecretion， mast cell degranulation， and airway hyper-responsiveness (AHR) in a mouse asthma model， probably via inhibition of NF-κB activity[1]. |
| In Vivo |
14-deoxy-11，12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine[1]. |
| 细胞实验 |
A549 cells (3×103/well)， BEAS-2B cells (5×103/well)， and RBL-2H3 cells (3×103/well) are seeded in flat-bottomed 96-well plates overnight and then incubated with increasing concentrations (3-120 μM) of 14-deoxy-11，12-didehydroandrographolide or Andrographolide for 24 and 48 h at 37°C. Cell viability is analyzed using the CellTiter 96 AQueous cell proliferation assay. This MTS assay is based on the ability of viable cells to convert a soluble tetrazolium salt to a colored formazan product. Absorbance is recorded at 490 nm[1]. |
| 动物实验 |
Mice[1] Female BALB/c mice， 6 to 8 weeks old， are sensitized and challenged with OVA. Briefly， mice are sensitized by ip injections of 20 μg of OVA and 4 mg of Al(OH)3 suspended in 0.1 mL of saline on days 0 and 14. On days 22， 23， and 24， mice are challenged with 1% OVA aerosol for 30 min. 14-deoxy-11，12-didehydroandrographolide (0.1， 0.5， and 1 mg/kg) or vehicle (1% DMSO) in 0.1 mL of saline is given by ip injections 2 h before and 10 h after each OVA aerosol challenge. Saline aerosol is used as a negative control. |
| 数据来源文献 |
[1]. Guan SP， et al. Protective role of 14-deoxy-11，12-didehydroandrographolide， a noncytotoxic analogue ofandrographolide， in allergic airway inflammation. J Nat Prod. 2011 Jun 24;74(6):1484-90. |
| 规格 |
1mg 5mg 10mg 25mg |
| 单位 |
瓶 |
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