类叶升麻苷(10mM in DMSO,无菌）_索莱宝|主营生物科研试剂&抗体|蛋白|多肽|试剂盒|专业定制化服务平台-Solarbio【网上商城】

生化试剂

抗生素维生素动植物激素酸&盐&胺糖及衍生物脂质＆脂肪酸衍生物核酸&核苷酸及衍生物氨基酸&蛋白质酶&辅酶表面活性剂&去垢剂&螯合剂氘代试剂稳定同位素反应底物常规生化试剂通用缓冲液

蛋白与免疫

重组蛋白蛋白提取/定量免疫佐剂细胞全蛋白抗原蛋白电泳抗体标记试剂盒其它实验试剂

多肽

封闭肽化妆品肽目录肽定制肽

抗体

一抗二抗内参抗体细菌抗体标签抗体 RNA抗体植物抗体小分子抗体病毒抗体

ELISA

人小鼠大鼠通用其他种属未包被试剂盒抗体对 Elisa辅助试剂

流式分析

流式辅助试剂

分子生物学

核酸提取/纯化 PCR/qPCR 分子克隆相关酶核酸电泳重组克隆表达质粒分子杂交分子生物学辅助试剂 MBI原装

细胞生物学

细胞系（株）细胞器提取试剂盒细胞培养基Kit 细胞培养与消化细胞分离液细胞生长因子细胞检测鲎试剂植物培养

小分子化合物

迷你化合物Kit 抑制剂＆拮抗剂＆激动剂疾病造模剂明星产品 Peptides 化合物库 PROTAC/蛋白降解靶向嵌合分子同位素标记物氨基酸及其衍生物 Anti-infection/抗感染糖类及其衍生物维生素及其衍生物助溶剂&增溶剂染料&探针反应底物&理化检测实验常用溶液

生化试剂盒

氮代谢系列脂肪酸代谢系列糖类代谢系列其他生化系列氧化还原系列蛋白及酶类系列能量代谢系列

染色试剂

染色原料荧光染色液 HE染色液组织染色液植物染色液酶类染色液特殊细胞染色液胞内组分染色液微生物染色液辅助试剂组织切片制备试剂

分析标准品

分析对照品紫外分光标准品可溯源标准品对照药材仪器检定标液单标溶液混标套装液相色谱用试剂盒分析辅助试剂质控标样/基质标物代销产品

微生物培养

菌株培养基基础培养基原料培养基添加剂发酵专用产品酵母缺陷型培养基其他微生物培养基微生物辅助试剂 OXOID原装

层析介质

预装柱填料

磁珠

纯化磁珠免疫沉淀纳米抗体磁珠基础磁珠

仪器、耗材

基础耗材培养耗材 PCR&分子生物学耗材 WB&免疫耗材药敏纸片病理制片耗材安全防护耗材其他耗材层析用耗材实验仪器

纳米材料

石墨/石墨烯类石墨烯碳纳米材料无机纳米材料分子筛金属纳米材料其它纳米材料

化学合成

分子砌块 PEG衍生物金属材料

SKU	北京总部	北京海淀	武汉	广州
IV00501-1ml	咨询	咨询	咨询	咨询

CAS	No.61276-17-3
中文名称	类叶升麻苷(10mM in DMSO,无菌）
英文名称	Verbascoside(10mM in DMSO，Sterile）
分子式	C₂₉H₃₆O₁₅
分子量	624.59
溶解性	请根据自己的实验要求使用。
外观(性状)	无菌溶液
储存条件	Stroe at -20℃，6 months.
靶点	PKC
通路	TGF-beta/Smad;Epigenetics
背景说明	Verbascoside 为 ATP 竞争性的 PKC 抑制剂。
生物活性	Verbascoside is isolated from Acanthus mollis， acts as an ATP-competitive inhibitor of PKC， with an IC50 of 25 μM， and has antitumor， anti-inflammatory and antineuropathic pain activity.[1-3]
In Vitro	Verbascoside acts as an ATP-competitive inhibitor of PKC， with an IC50 of 25 μM. Verbascoside shows Kis of 22 and 28 μM with respect to ATP and histone， respectively. Verbascoside has potent antitumor activity against L-1210 cells， with an IC50 of 13 μM[1]. Verbascoside (5， 10 μM) suppresses 2，4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54， proinflammatory cytokines， and NFκB pathway activation in THP-1 cells[2].
In Vivo	Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2，4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α， IL-6， and IL-4 mRNA in skin lesions[2]. Verbascoside (50， 100 mg/kg， i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg， i.p.) decreases hyper-sensitivity to cold stimulus， acetone， on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover， Verbascoside decreases Bax and increases Bcl-2 on day 3[3].
细胞实验	The lymphocytic mouse leukemia L1210 cells (ATCC， CCL 219) are plated sparsely at 104 cells per well in 24-well cluster plates in Dulbecco’s modified Eagle medium containing 10% fetal calf serum， 4 mM glutamine， 100 U/mL penicillin， 100 μg/mL streptomycin sulfate， and Verbascoside (solubilized in DMSO). After a 2-day incubation period at 37°C in a humidified atmosphere (5% CO2 in air)， growth is monitored by counting cell numbers in a Coulter-counter. IC50 values are calculated on the basis of the linear regression lines established for each compound tested[1].
动物实验	Rats[2]To induce atopic dermatitis (AD)-like symptoms， 2，4-dinitrochlorobenzene (DNCB) is used. Briefly， the dorsal hair of the mice is removed using an electronic clipper 2 days before DNCB treatment. An application of 200 μL of 1% DNCB (in acetone:olive oil = 4:1) is made to the shaved dorsal skin for sensitization. The repeated challenge is performed on the same site with 0.2% DNCB once every 3 days for about 2 weeks. The mice are divided into 4 groups (n = 6 per group): (1) vehicle-treated controls， (2) DNCB-treated only， (3) 1% Verbascoside (in acetone:olive oil 4:1)-treated only， and (4) DNCB + 1% Verbascoside-treated group[2].
数据来源文献	[1]. Herbert JM， et al. Verbascoside isolated from Lantana camara， an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600. [2]. Li Y， et al. Verbascoside Alleviates Atopic Dermatitis-Like Symptoms in Mice via Its Potent Anti-Inflammatory Effect. Int Arch Allergy Immunol. 2018;175(4):220-230. [3]. Amin B， et al. The Effect of Verbascoside in Neuropathic Pain Induced by Chronic Constriction Injury in Rats. Phytother Res. 2016 Jan;30(1):128-35.
规格	1ml
单位	瓶