特班布林(10mM in DMSO,无菌）_索莱宝|主营生物科研试剂&抗体|蛋白|多肽|试剂盒|专业定制化服务平台-Solarbio【网上商城】

生化试剂

抗生素维生素动植物激素酸&盐&胺糖及衍生物脂质＆脂肪酸衍生物核酸&核苷酸及衍生物氨基酸&蛋白质酶&辅酶表面活性剂&去垢剂&螯合剂氘代试剂稳定同位素反应底物常规生化试剂通用缓冲液

蛋白与免疫

重组蛋白蛋白提取/定量免疫佐剂细胞全蛋白抗原蛋白电泳抗体标记试剂盒其它实验试剂

多肽

封闭肽化妆品肽目录肽定制肽

抗体

一抗二抗内参抗体细菌抗体标签抗体 RNA抗体植物抗体小分子抗体病毒抗体

ELISA

人小鼠大鼠通用其他种属未包被试剂盒抗体对 Elisa辅助试剂

流式分析

流式辅助试剂

分子生物学

核酸提取/纯化 PCR/qPCR 分子克隆相关酶核酸电泳重组克隆表达质粒分子杂交分子生物学辅助试剂 MBI原装

细胞生物学

细胞系（株）细胞器提取试剂盒细胞培养基Kit 细胞培养与消化细胞分离液细胞生长因子细胞检测鲎试剂植物培养

小分子化合物

迷你化合物Kit 抑制剂＆拮抗剂＆激动剂疾病造模剂抗体抑制剂明星产品 Peptides 化合物库 PROTAC/蛋白降解靶向嵌合分子同位素标记物氨基酸及其衍生物 Anti-infection/抗感染糖类及其衍生物维生素及其衍生物助溶剂&增溶剂染料&探针反应底物&理化检测实验常用溶液

生化试剂盒

氮代谢系列脂肪酸代谢系列糖类代谢系列其他生化系列氧化还原系列蛋白及酶类系列能量代谢系列

染色试剂

染色原料荧光染色液 HE染色液组织染色液植物染色液酶类染色液特殊细胞染色液胞内组分染色液微生物染色液辅助试剂组织切片制备试剂

分析标准品

分析对照品紫外分光标准品可溯源标准品对照药材仪器检定标液单标溶液混标套装液相色谱用试剂盒分析辅助试剂质控标样/基质标物代销产品

微生物培养

菌株培养基基础培养基原料培养基添加剂发酵专用产品酵母缺陷型培养基其他微生物培养基微生物辅助试剂 OXOID原装

层析介质

预装柱填料

磁珠

纯化磁珠免疫沉淀纳米抗体磁珠基础磁珠

仪器、耗材

基础耗材培养耗材 PCR&分子生物学耗材 WB&免疫耗材药敏纸片病理制片耗材安全防护耗材其他耗材层析用耗材实验仪器

纳米材料

石墨/石墨烯类石墨烯碳纳米材料无机纳米材料分子筛金属纳米材料其它纳米材料

化学合成

分子砌块 PEG衍生物金属材料

SKU	北京总部	北京海淀	武汉	广州
IF06001-1ml	咨询	咨询	咨询	咨询

CAS	No.897016-82-9
中文名称	特班布林(10mM in DMSO,无菌）
英文名称	Tirbanibulin(10mM in DMSO，Sterile）
分子式	C₂₆H₂₉N₃O₃
分子量	431.53
溶解性	请根据自己的实验要求使用。
外观(性状)	无菌溶液
储存条件	Stroe at -20℃，6 months.
运输条件	冷冻运输
靶点	Src
通路	Protein Tyrosine Kinase/RTK
背景说明	是拟肽类Src抑制剂，靶向Src的多肽底物结合位点。
生物活性	Tirbanibulin (KX2-391) is an inhibitor of Src that targets the peptide substrate site of Src， with GI50 of 9-60 nM in cancer cell lines.[1-2]
IC50	GI50: 9 nM (Src， in HuH7 cells)， 13 nM (Src， in PLC/PRF/5 cells)， 26 nM (Src， in Hep3B cells)， 60 nM (Src， in HepG2 cells)[1]
In Vitro	Tirbanibulin (KX2-391) is a Src inhibitor that is directed to the Src substrate pocket. Tirbanibulin (KX2-391) shows steep dose-response curves against Huh7 (GI50=9 nM)， PLC/PRF/5 (GI50=13 nM)， Hep3B (GI50=26 nM)， and HepG2 (GI50=60 nM)， four hepatic cell cancer (HCC) cell lines[1]. Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs， such as those derived from chronic leukemia cells with the T3151 mutation. Tirbanibulin (KX2-391) is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM， respectively[2].
In Vivo	Orally administered Tirbanibulin (KX2-391) is shown to inhibit primary tumor growth and to suppress metastasis， in pre-clinical animal models of cancer[2].
细胞实验	Liver cell lines including Huh7， PLC/PRF/5， Hep3B， and HepG2 are routinely cultured and maintained in basal medium containing 2% fetal bovine serum (FBS) at 37°C and 5% CO2. Cells are seeded at 4.0×103/190 μL and 8.0×103/190 μL per well of 96-well plate in basal medium containing 1.5% FBS. These are cultured overnight at 37°C and 5% CO2 prior to the addition of Tirbanibulin (KX2-391)， at concentrations ranging from 6，564 to 0.012 nM in triplicates. Treated cells are incubated for 3 days. Ten μLs of 3-(4，5-dimethylthiazol- 2-yl)-2，5-diphenyltetrazolium bromide (MTT) solution (5 mg/mL) is then added to each well on day 3 and cells incubated for 4 hours. The formazan product is dissolved with 10% SDS in dilute HCl. Optical density at 570 nm is measured. For comparison of activity and potency， parallel experiments are performed using Tirbanibulin (KX2-391). Growth inhibition curves， 50% inhibition concentration (GI50)， and 80% inhibition concentration (GI80) are determined using GraphPad Prism 5 statistical software. Data are normalized to represent percentage of maximum response as well as reported in optical density at wavelength of 570 nm (OD570) signal format[1].
数据来源文献	[1]. Lau GM， et al. Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. Dig Dis Sci， 2009， 54(7)， 1465-1474. [2]. Fallah-Tafti A， et al. Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis， Src kinase inhibitory and anticancer activities. Eur J Med Chem， 2011， 46(10)， 4853-4858.
规格	1ml
单位	瓶