| CAS |
No.29883-15-6 |
| 中文名称 |
苦杏仁苷(10mM in DMSO,无菌） |
| 英文名称 |
Amygdalin(10mM in DMSO，Sterile） |
| 分子式 |
C20H27NO11 |
| 分子量 |
457.43 |
| 溶解性 |
请根据自己的实验要求使用。 |
| 外观(性状) |
无菌溶液 |
| 储存条件 |
Stroe at -20℃，6 months. |
| 靶点 |
Others |
| 通路 |
Others |
| 背景说明 |
是一种糖苷，主要存在于苦杏、苦扁桃、桃、油桃(nectarines)、枇杷、李子、苹果、黑樱桃等果仁和叶子中。 |
| 生物活性 |
Amygdalin is a plant glucoside isolated from the stones of rosaceous fruits， such as apricots， peaches， almond， cherries， and plums.[1-3] |
| In Vitro |
Amygdalin has antitumor activity. Some advances had been made on the antitumor mechanism of amygdalin[1]. Amygdalin downregulates especially genes belonging to cell cycle category: exonuclease 1， ATP-binding cassette， sub-family F， member 2， MRE11 meiotic recombination 11 homolog A， topoisomerase (DNA) I， and FK506 binding protein 12-rapamycin-associated protein 1. RT-PCR analysis reveals that mRNA levels of these genes are also decreased by amygdalin treatment in SNU-C4 human colon cancer cells[2]. |
| In Vivo |
Amygdalin is effective at alleviating inflammatory pain and that it can be used as an analgesic with anti-nociceptive and anti-inflammatory activities. The intramuscular injection of amygdalin significantly reduced the formalin-induced tonic pain in both early (the initial 10 min after formalin injection) and late phases (10-30 min following the initial formalin injection). During the late phase， amygdalin reduces the formalin-induced pain in a dose-dependentmanner in a dose range less than 1 mg/kg[3]. |
| 细胞实验 |
Cell viability is determined by MTT assay. Cells are seeded in triplicate at a concentration of 1×105 cells/well on a 96-well plate. SNU-C4 cells are treated with amygdalin at concentrations of 0.25， 0.5， 2.5， and 5 mg/mL for 24 h. After MTT is added to each group， the cells are incubated for 4 h. Then， they are further incubated for 1 h， including the solution in which MTT is dissolved[2]. |
| 动物实验 |
Rats: The amygdalin powder is dissolved in saline and diluted with appropriate medium. Male Sprague–Dawley rats weighing 230-250 g are used for this experiment. 50mL of 5% formalin are injected to produce fomalin-induced pain in the rats. Thirty minutes before the formalin injection to induce pain， the rats are given an intramuscular injection of amygdalin solution (0.1， 0.5， 1.0， 10 mg/kg)， or saline as a vehicle control[3]. |
| 数据来源文献 |
[1]. Song Z， et al. Advanced research on anti-tumor effects of amygdalin. J Cancer Res Ther. 2014 Aug;10 Suppl 1:3-7.
[2]. Park HJ，et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol. 2005 Sep 7;11(33):5156-61.
[3]. Hwang HJ，et al. Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biol Pharm Bull. 2008 Aug;31(8):1559-64. |
| 规格 |
1ml |
| 单位 |
瓶 |
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