地奥司明(10mM in DMSO,无菌）_索莱宝|主营生物科研试剂&抗体|蛋白|多肽|试剂盒|专业定制化服务平台-Solarbio【网上商城】

生化试剂

抗生素维生素动植物激素酸&盐&胺糖及衍生物脂质＆脂肪酸衍生物核酸&核苷酸及衍生物氨基酸&蛋白质酶&辅酶表面活性剂&去垢剂&螯合剂氘代试剂稳定同位素反应底物常规生化试剂通用缓冲液

蛋白与免疫

重组蛋白蛋白提取/定量免疫佐剂细胞全蛋白抗原蛋白电泳抗体标记试剂盒其它实验试剂

多肽

封闭肽化妆品肽目录肽定制肽

抗体

一抗二抗内参抗体细菌抗体标签抗体 RNA抗体植物抗体小分子抗体病毒抗体

ELISA

人小鼠大鼠通用其他种属未包被试剂盒抗体对 Elisa辅助试剂

流式分析

流式辅助试剂

分子生物学

核酸提取/纯化 PCR/qPCR 分子克隆相关酶核酸电泳重组克隆表达质粒分子杂交分子生物学辅助试剂 MBI原装

细胞生物学

细胞系（株）细胞器提取试剂盒细胞培养基Kit 细胞培养与消化细胞分离液细胞生长因子细胞检测鲎试剂植物培养

小分子化合物

迷你化合物Kit 抑制剂＆拮抗剂＆激动剂疾病造模剂抗体抑制剂明星产品 Peptides 化合物库 PROTAC/蛋白降解靶向嵌合分子同位素标记物氨基酸及其衍生物 Anti-infection/抗感染糖类及其衍生物维生素及其衍生物助溶剂&增溶剂染料&探针反应底物&理化检测实验常用溶液

生化试剂盒

氮代谢系列脂肪酸代谢系列糖类代谢系列其他生化系列氧化还原系列蛋白及酶类系列能量代谢系列

染色试剂

染色原料荧光染色液 HE染色液组织染色液植物染色液酶类染色液特殊细胞染色液胞内组分染色液微生物染色液辅助试剂组织切片制备试剂

分析标准品

分析对照品紫外分光标准品可溯源标准品对照药材仪器检定标液单标溶液混标套装液相色谱用试剂盒分析辅助试剂质控标样/基质标物代销产品

微生物培养

菌株培养基基础培养基原料培养基添加剂发酵专用产品酵母缺陷型培养基其他微生物培养基微生物辅助试剂 OXOID原装

层析介质

预装柱填料

磁珠

纯化磁珠免疫沉淀纳米抗体磁珠基础磁珠

仪器、耗材

基础耗材培养耗材 PCR&分子生物学耗材 WB&免疫耗材药敏纸片病理制片耗材安全防护耗材其他耗材层析用耗材实验仪器

纳米材料

石墨/石墨烯类石墨烯碳纳米材料无机纳米材料分子筛金属纳米材料其它纳米材料

化学合成

分子砌块 PEG衍生物金属材料

SKU	北京总部	北京海淀	武汉	广州
ID06401-1ml	咨询	咨询	咨询	咨询

CAS	No.520-27-4
中文名称	地奥司明(10mM in DMSO,无菌）
英文名称	Diosimin(10mM in DMSO，Sterile）
分子式	C₂₈H₃₂O₁₅
分子量	608.54
溶解性	请根据自己的实验要求使用。
外观(性状)	无菌溶液
储存条件	Stroe at -20℃，6 months.
运输条件	冷冻运输
靶点	AhR(Aryl Hydrocarbon Receptor)
通路	Immunology & Inflammation
背景说明	Diosmin 是芳烃受体 (AhR) 的激动剂。
生物活性	Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).[1-2]
In Vitro	Treatment with Diosmin causes a dose dependent increase in the amount of adducts formed (up to a 7-fold increase in adducts at 5 μM Diosmin). At 5 μM， Diosmin increases the cytotoxicity of 7，12-dimethylbenz(a)anthracene， shifting the IC50 from an estimated 1.2 μM to 400 nM. Diosmin is not cytotoxic in itself at the concentrations tested. Diosmin causes an increase in CYPIAI activity in MCF-7 cells in a time- and dose-dependent fashion. Diosmin causes a dose-dependent increase in CYPIAI mRNA after 24 h of incubation， causes a long-lasting increase in CYPIAI mRNA accumu lation that reaches its peak after 48 h of incubation[1].
In Vivo	Diosmin significantly decreases the malondialdehyde (MDA) levels and increases the activities of total-superoxide dismutase (T-SOD)， glutathione peroxidase (GSH-Px)， and catalase (CAT) in the retina of rats compare with the ischemia group (P[2].
细胞实验	MCF-7 cells are plated at 25，000 cells/well in 24-well plates. After 24 h， the medium is changed to medium containing 5 μM Diosmin. After an additional 24 h， the medium is again changed with medium containing 5 μM Diosmin. After 3 days， the total cell growth is assessed by sulforhodamine[1].
动物实验	Healthy male Wistar rats (n=112) weighing 180 to 200?g each are used in this study. The animals are randomly assigned to the following 4 groups， which include combinations of the ischemia/reperfusion (I/R) injury model or sham injury with the i.g. administration of Diosmin or vehicle solution: sham+vehicle (SV) group， sham+Diosmin (SD) group， model+vehicle (MV) group， and model+Diosmin (MD) group. For intragastric administration， 5?mL of 2% Diosmin per kilogram weight of the rat， or the same volume of vehicle solution， is administered intragastrically 30?min before the onset of ischemia， and then daily after I/R injury until the animals are sacrificed. Using an overdose of anesthesia， 8 rats from each group are sacrificed 24?h after I/R injury， and their eyeballs harvested for determination of the malondialdehyde (MDA) level and the activities of total-superoxide dismutase (T-SOD)， glutathione peroxidase (GSH-Px)， and catalase (CAT). At 7 days post-I/R injury， electroretinograms (ERGs) are recorded in 6 rats per group. Meanwhile， 6 rats in each group are randomly chosen for retrograde labeling of retinal ganglion cells (RGCs) ， and the remaining 8 rats from each group are histopathologically examined[2].
数据来源文献	[1]. Ciolino HP， et al. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affectcytochrome P450 1A1 activity. Cancer Res. 1998 Jul 1;58(13):2754-60. [2]. Tong N， et al. Diosmin protects rat retina from ischemia/reperfusion injury. J Ocul Pharmacol Ther. 2012 Oct;28(5):459-66.
规格	1ml
单位	瓶