| CAS |
No.10030-73-6 |
| 中文名称 |
软脂酸 |
| 英文名称 |
Palmitelaidic Acid |
| 分子式 |
C16H30O2 |
| 分子量 |
254.41 |
| 溶解性 |
Soluble in Ethanol |
| 纯度 |
≥98% |
| 级别 |
Cell Culture |
| 外观(性状) |
Colorless to light yellow Liquid |
| 储存条件 |
Store at -20℃，2 years. |
| 运输条件 |
冷冻运输 |
| 靶点 |
Others |
| 通路 |
Others |
| 背景说明 |
Palmitelaidic Acid 是棕榈油酸 palmitoleic acid 的反式异构体。 |
| 生物活性 |
Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.[1-3] |
| In Vitro |
The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues， particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform， cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors， including high blood pressure， total cholesterol， TGs， apoA-I， apoB， and endothelial dysfunction[1]. |
| In Vivo |
Palmitoleic acid promotes a faster uptake of glucose in the body， associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK， up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream， palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα[2]. Palmitoleic acid reduces body weight increase， ameliorates the development of hyperglycemia and hypertriglyceridemia， and improves insulin sensitivity. Furthermore， palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1， FAS， and SCD-1) in liver[3]. |
| 动物实验 |
Mice: Male C57BL/6J wild type and PPARα-KO mice are fed a high-fat diet or a standard diet for 12 weeks. In the last two weeks， the HF-fed mice are treated daily with oleic acid (300 mg/kg of body weight) or palmitoleic acid (00 mg/kg of body weight) by oral gavage. After 12 weeks， the mice are fasted for 6 h， injected with insulin or PBS vehicle. Blood and liver samples are collected and stored for the further analysis of RNA and protein expression[2]. |
| 数据来源文献 |
[1]. Frigolet ME， et al. The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease.
[2]. de Souza CO， et al. Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation. J Cell Physiol. 2016 Dec 7. doi: 10.1002/jcp.25715.
[3]. Yang ZH， et al. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids Health Dis. 2011 Jul 21;10:120. |
| 规格 |
10mg |
| 单位 |
瓶 |
中文
英语
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