Xenin_索莱宝|主营生物科研试剂&抗体|蛋白|多肽|试剂盒|专业定制化服务平台-Solarbio【网上商城】

产品类型	多肽
CAS	No.144092-28-4
单字母序列	MLTKFETKSARVKGLSFHPKRPWIL
三字母序列	Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu
分子式	C139H224N38O32S1
分子量	2971.57
纯度	≥95%
外观(性状)	冻干粉;Lyophilized powder
盐体系	TFA盐;Trifluoroacetate salt
来源	合成;Synthetic
储存条件	Store at -20℃，2 years.(Avoid freeze/thaw cycles)
背景说明	Xenin是最初从人胃粘膜分离出来的由25个氨基酸组成的多肽。 Xenin是可以减少食欲的肠激素。
In Vivo	Both intracerebroventricular and intraperitoneal administration of xenin inhibit fasting-induced hyperphagia in wild-type mice in a dose-dependent manner. The intraperitoneal injection of xenin also reduces nocturnal intake in ad libitum–fed wild-type mice. The intraperitoneal injection of xenin increases Fos immunoreactivity in hypothalamic nuclei， including the paraventricular nucleus and the arcuate nucleus. Xenin reduces food intake in agouti and ob/ob mice. Gastric emptying rate is reduced by about 93% in xenin-treated mice compared to saline-treated control mice. The i.p. xenin injection significantly increases Fos-immunoreactive cells in the nucleus of the solitary tract of the brainstem， but not area postrema and dorsal motor nucleus of the vagus.
In Vitro	Xenin is abundantly expressed in gastric， duodenal， and jejunal mucosa， and is found at lower levels in the pancreas. Xenin is released into the circulation postprandially and has been reported to stimulatepancreatic endocrine and exocrine secretion， inhibit gastrin secretion， and influence gastrointestinal motility. Xenin is highly homologous to neurotensin. Xenin and neurotensin are reported to have similar biological effects.
参考文献	[1]. Cooke JH， et al. Peripheral and central administration of xenin and neurotensin suppress food intake in rodents. Obesity (Silver Spring). 2009 Jun;17(6):1135-43. [2]. Leckstrom A， et al. Xenin， a gastrointestinal peptide， regulates feeding independent of the melanocortinsignaling pathway. Diabetes. 2009 Jan;58(1):87-94. [3]. Kim ER， et al. Xenin delays gastric emptying rate and activates the brainstem in mice. Neurosci Lett. 2010 Aug 30;481(1):59-63.
研究领域	新陈代谢
规格	1mg 5mg 10mg
单位	瓶
分类属性	目录肽