| 产品类型 |
多肽 |
| CAS |
No.1208243-50-8 |
| 单字母序列 |
pGlu-EQLERALNSS |
| 三字母序列 |
Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| 别名 |
ARA290 |
| 分子式 |
C51H84N16O21 |
| 分子量 |
1257.31 |
| 纯度 |
≥95% |
| 外观(性状) |
冻干粉;Lyophilized powder |
| 溶解性 |
H2O：66.67 mg/mL (adjust pH to 8 with NH3·H2O);
0.1 M NaOH：≥ 50 mg/mL;
*超声助溶; |
| 盐体系 |
TFA盐;Trifluoroacetate salt |
| 来源 |
合成;Synthetic |
| 储存条件 |
Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| 运输条件 |
冷冻运输 |
| 背景说明 |
Cibinetide (ARA290) 是一种 EPO 衍生物，为特异性的 erythropoietin/CD131 heteroreceptor 的激动剂，常用于神经系统疾病研究。 |
| In Vivo |
After ECFC transplantation to mice with CLI， a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4 h after transplantation.
Cibinetide (ARA290; 30 μg/kg， s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats.
Low-dosage Cibinetide (35 μg/kg， i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg， i.p.) significantly delays the onset， decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way. |
| In Vitro |
Cibinetide (ARA290) enhances the proliferation， migration， and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs).
Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects. |
| 参考文献 |
[1]. Hache G， et al. ARA290， a Specific Agonist of Erythropoietin/CD131 Heteroreceptor， Improves Circulating Endothelial Progenitors’ Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46(4):390-7
[2]. Carole Muller， et al. ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats. Mol Med. 2015; 21(1): 969–978
[3]. Chen H， et al. Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat. J Neuroimmunol. 2014 Mar 15;268(1-2):64-70 |
| 研究领域 |
神经科学研究 |
| 规格 |
1mg 5mg 10mg |
| 单位 |
瓶 |
| 分类属性 |
目录肽 |
中文
英语
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