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链脲佐菌素 STZ
CAS:No.18883-66-4
分子式:C8H15N3O7
分子量:265.22
储存条件:-20℃避光，有效期2年
纯度:Min.75% as α-anomer
英文名称:Streptozocin STZ
产品简介
| 别名 | N-(Methylnitrosocarbamoyl)-α-D-glucosamine； Streptozotocin；链脲菌素 |
| 英文名称 | Streptozocin STZ |
| CAS | No.18883-66-4 |
| 分子式 | C8H15N3O7 |
| 分子量 | 265.22 |
| 储存条件 | -20℃避光，有效期2年 |
| 外观(性状) |
白色至淡黄色粉末
|
| 纯度 | Min.75% as α-anomer |
| 溶解性 | 10mg/mL in 柠檬酸缓冲液（pH4.2-4.5），20mg/mL in Water |
| 危险代码 | R：40 S：36/37 |
| 规格 | 100mg 1g 5g |
| 单位 | 瓶 |
说明：DNA有效甲基化试剂；对实验动物能产生糖尿病，建立糖尿病模型。
特性：纯度：≥98%,≥75% α-anomer basis
熔点：121℃ (dec.)
保存：-20℃
使用说明：STZ 需要用柠檬酸和柠檬酸钠配制而成的pH4.2 -4.5（Cat：C1013）缓冲液配置。
用途：生化研究。本品为Stre.achromogenes Uar.128产生的亚硝脲类抗生素，它与脂溶性的亚硝脲不同，在氯乙基处是一个甲基，在分子的另一端是一个氨基糖。STZ可自行分解活泼的甲基正碳离子，与DNA呈链间交叉连结，从而使DNA烷化，但其烷化作用比其他亚硝脲类药物弱，而其代谢产物甲基亚硝脲的烷化作用较其STZ强3~4倍。STZ在体内可形成异氰酸盐。从而与核酸蛋白结合，抑制DNA多聚酶活力，使受损的DNA难于修复。在进行抗肿瘤研究过程中发现，STZ可使鼠类的血糖升高，在犬及猴可致糖尿病，且呈永久性。STZ的糖尿病作用具有种属差异性，在豚鼠不引起，在人亦不引起。其致糖尿病机制主要是由于胰岛细胞中菸酰胺腺嘌呤（DNA）含量减少，STZ分子中的葡萄糖基可使STZ进入胰岛β细胞，引起β细胞核内形态变化，使其染色体凝集、伸长和浓缩。
STZ造模注意事项（参考）：
1，本品易潮解失活，应避免其受潮，受潮后30分钟后失效，其水溶液不稳定, STZ要求干燥避光，推荐用干燥铝箔（或锡箔）。
2，配置:柠檬酸缓冲液以1-2％的浓度溶解STZ,冰浴,注射前现配。
3，要求快速注射, 容易形成高血糖，推注的速度慢，危险性较低，但不容易成模. 当然，STZ的剂量是决定血糖高低的主要因素。
4，柠檬酸缓冲液在pH为4.2-4.5时较稳定，偏大或偏小都易造成产品失活。
模型不达标者，三天后可补注STZ（以10mg-20mg/kg体重剂量腹腔注射），也很容易成模，或让血糖恢复正常后再常规剂量注射；但要达到理想的效果，往往是恢复到正常状态下重新造模。
注射剂量（参考）：
Ⅰ型糖尿病模型：大鼠剂量为65-70mg/kg； 或参考产品说明与文献。
Ⅱ型糖尿病模型：高糖高脂喂养1-2个月的大鼠，STZ剂量在25-40mg/kg或参考文献。
备注：产品信息可能会有优化升级。请以实际标签信息为准。
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these
methods.
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Lisha Chen, Hongji Wang, Juping Xing, Xiangchao Shi, Huan Huang, Jiabao Huang, Changshui Xu
IF：
6.2080
Publish_to：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：
36430617
Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin
点击查看 >>
Author：
Fu Qian, Song Yilin, Ling Zhaoke, Liu Jie, Kong Qingqing, Hao Xin, Xu Ting, Zhang Qiang, Liu Yi
IF：
6.2000
Publish_to：
DIABETES
PMID：
38869375
Oat β-glucan ameliorates diabetes in high fat diet and streptozotocin-induced mice by regulating metabolites
点击查看 >>
Author：
Huiqin Guo, Haili Wu, Xiangqun Kong, Nuonuo Zhang, Hanqing Li, Xiushan Dong, Zhuoyu Li
IF：
6.1170
Publish_to：
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
PMID：
36513312
The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway
点击查看 >>
Author：
Yang Xian, XingLi Wang, Yong Yu, XiaoLong Chen
IF：
6.1000
Publish_to：
LIFE SCIENCES
PMID：
38307238
Effects of the synbiotic composed of mangiferin and Lactobacillus reuteri 1–12 on type 2 diabetes mellitus rats
点击查看 >>
Author：
Fanying Meng, Fan Zhang, Meng Meng, Qiuding Chen, Yaqin Yang, Wenbo Wang, Haina Xie, Xue Li, Wen Gu, Jie Yu
IF：
6.0640
Publish_to：
Frontiers in Microbiology
PMID：
37152739
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion
点击查看 >>
Author：
Shan Jiang, Chun-mei Xu, Shuai Yao, Rui Zhang, Xian-zhi Li, Ru-zhen Zhang, Tian-yue Xie, Yi-qian Xing, Qian Zhang, Xiao-jun Zhou, Lin Liao, Jian-jun Dong
IF：
6.0550
Publish_to：
Frontiers in Endocrinology
PMID：
36034435
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy
点击查看 >>
Author：
Yujie Zhong, Ruilin Luo, Qi Liu, Jiachang Zhu, Min Lei, Xiaofei Liang, Xin Wang, Xiaoli Peng
IF：
6.0250
Publish_to：
FOOD AND CHEMICAL TOXICOLOGY
PMID：
34826549
Fiber-reinforced gelatin/β-cyclodextrin hydrogels loaded with platelet-rich plasma-derived exosomes for diabetic wound healing
点击查看 >>
Author：
Qiu-Hao Shu, Rong-Tai Zuo, Min Chu, Jing-Jing Shi, Qin-Fei Ke, Jun-Jie Guan, Ya-Ping Guo
IF：
6.0000
Publish_to：
Biomaterials Advances
PMID：
37804684
Natural and biocompatible dressing unit based on tea carbon dots modified core-shell electrospun fiber for diabetic wound disinfection and healing
点击查看 >>
Author：
Zhenyou Dong, Junhui Yin, Xueqing Zhou, Suyun Li, Zhenyu Fu, Pei Liu, Longxiang Shen, Wenyan Shi
IF：
5.9990
Publish_to：
COLLOIDS AND SURFACES B-BIOINTERFACES
PMID：
37148664
OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1
点击查看 >>
Author：
Yao Enhui, Luo Lili, Lin Chenxi, Wen Jing, Li Yanglongfei, Ren Tong, Chen Yujie, Huang Jinhua, Jin Xin
IF：
5.9880
Publish_to：
Frontiers in Pharmacology
PMID：
36452230
Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics
点击查看 >>
Author：
Yujie Zhong, Ruyi Jin, Ruilin Luo, Jiayu Liu, Luting Ren, Yinghan Zhang, Zhongguo Shan, Xiaoli Peng
IF：
5.9000
Publish_to：
Nutrients
PMID：
37630743
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation
点击查看 >>
Author：
Kai Song, He Sun, Bin Tu, Yang Zhou, Li-Chan Lin, Zhi-Yan Liu, Rui Li, Jing-Jing Yang, Ye Zhang, Jian-Yuan Zhao, Hui Tao
IF：
5.8000
Publish_to：
iScience
PMID：
37810250
Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice
点击查看 >>
Author：
Xianan Dong, Liangliang Kong, Lei Huang, Yong Su, Xuewang Li, Liu Yang, Pengmin Ji, Weiping Li, Weizu Li
IF：
5.7350
Publish_to：
Journal of Ginseng Research
PMID：
37252275
Bacillus toyonensis SAU-19 Ameliorates Hepatic Insulin Resistance in High-Fat Diet/Streptozocin-Induced Diabetic Mice
点击查看 >>
Author：
Samuel Kumi Okyere, Lei Xie, Juan Wen, Yinan Ran, Zhihua Ren, Junliang Deng, Yanchun Hu
IF：
5.7190
Publish_to：
Nutrients
PMID：
34960064
Therapeutic efficacy of dapagliflozin on diabetic kidney disease in rats
点击查看 >>
Author：
Huijuan Yang, Zhijie Mei, Weidong Chen, Yan Pan, Lei Liu, Ruiping Zhao, Wenjing Ni, Yanfei Wang, Chengqiu Fei
IF：
5.7140
Publish_to：
INTERNATIONAL IMMUNOPHARMACOLOGY
PMID：
36252493
Platycodin D Ameliorates Type 2 Diabetes-Induced Myocardial Injury by Activating the AMPK Signaling Pathway
点击查看 >>
Author：
Wenting Wang, Zi Wang, Zhaojie Meng, Shuang Jiang, Zhi Liu, Hong-yan Zhu, Xin-dian Li, Jing tian Zhang, Wei Li
IF：
5.7000
Publish_to：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
PMID：
38682702
Elucidation of endothelial progenitor cell dysfunction in diabetes by RNA sequencing and constructing lncRNA–miRNA–mRNA competing endogenous RNA network
点击查看 >>
Author：
Wan Gui, Xu Zhao, Xiang Xuejiao, Zhang Maojie, Jiang Tao, Chen Jing, Li Shengbo, Wang Cheng, Yan Chengqi, Yang Xiaofan, Chen Zhenbing
IF：
5.6060
Publish_to：
JOURNAL OF MOLECULAR MEDICINE-JMM
PMID：
36094536
Allicin ameliorates glucose and lipid metabolism via modulation of gut microbiota and bile acid profile in diabetic rats
点击查看 >>
Author：
Zhibin Wang, Lina Ding, Junjun Liu, Philippe Savarin, Xiaolei Wang, Ke Zhao, Wenyu Ding, Yanli Hou
IF：
5.6000
Publish_to：
Journal of Functional Foods
PMID：
Antidiabetic Effect of Millet Bran Polysaccharides Partially Mediated via Changes in Gut Microbiome
点击查看 >>
Author：
Jinhua Zhang, Wenjing Wang, Dingyi Guo, Baoqing Bai, Tao Bo, Sanhong Fan
IF：
5.5610
Publish_to：
Foods
PMID：
36360018
Renewable Electroconductive Hydrogels for Accelerated Diabetic Wound Healing and Motion Monitoring
点击查看 >>
Author：
Xiao Qian Hu, Jia Zhi Zhu, Zhaokun Hao, Letian Tang, Jian Sun, Wan Ru Sun, Jiaxiang Hu, Ping Yu Wang, Nicola Paccione Basmadji, José Luis Pedraz, Claudia Vairo, Eusebio Gainza Lafuente, Murugan Ramalingam, Shuyang Xie, Ranran Wang
IF：
5.5000
Publish_to：
BIOMACROMOLECULES
PMID：
38780026
Exploring the hypoglycemic mechanism of chlorogenic acids from Pyrrosia petiolosa (Christ) Ching on type 2 diabetes mellitus based on network pharmacology and transcriptomics strategy
点击查看 >>
Author：
Hanjiao He, Qing Wei, Jiao Chang, Xu Yi, Xiang Yu, Guoyong Luo, Xinfeng Li, Wude Yang, Yi Long
IF：
5.4000
Publish_to：
JOURNAL OF ETHNOPHARMACOLOGY
PMID：
38104881
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPKα/TGF-β/Smad signalling in type 2 diabetic rats
点击查看 >>
Author：
Jingjing Tian, Mingjun Zhang, Mengying Suo, Dian Liu, Xuyang Wang, Ming Liu, Jinyu Pan, Tao Jin, Fengshuang An
IF：
5.3100
Publish_to：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
PMID：
34169635
Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice
点击查看 >>
Author：
Liangliang Kong, Ran Sun, Huimsin Zhou, Qifeng Shi, Yan Liu, Min Han, Weiping Li, Sen Qun, Weizu Li
IF：
5.3000
Publish_to：
EXPERIMENTAL NEUROLOGY
PMID：
36791875
Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through Regulating the Gut Microbiota and Serum Metabolism
点击查看 >>
Author：
Xie Xuehua, Liao Jiabao, Ai Yuanliang, Gao Jinmei, Zhao Jie, Qu Fei, Xu Chao, Zhang Zhaiyi, Wen Weibo, Cui Huantian, Wang Hongwu
IF：
5.2930
Publish_to：
Frontiers in Cellular and Infection Microbiology
PMID：
34938667
Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats
点击查看 >>
Author：
Ziang Ma, Wenjuan Sun, Lixin Wang, Yuansong Wang, Baochao Pan, Xiuhai Su, Hanzhou Li, Hui Zhang, Shuquan Lv, Hongwu Wang
IF：
5.2000
Publish_to：
Frontiers in Endocrinology
PMID：
37732114
Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction
点击查看 >>
Author：
Hui Yang, Lin Tang, Zhan Qu, Shi-Hui Lei, Wei Li, Yu-Hong Wang
IF：
5.1350
Publish_to：
Neural Regeneration Research
PMID：
33907035
Combination treatment strategies with a focus on rosiglitazone and adriamycin for insulin resistant liver cancer
点击查看 >>
Author：
Yi-Fan Dang, Shao-Hui Yang, Xiao-Ning Jiang, Fu-Lian Gong, Xiao-Xia Yang, Yan-Na Cheng, Xiu-Li Guo
IF：
5.1210
Publish_to：
JOURNAL OF DRUG TARGETING
PMID：
33115283
Latilactobacillus sakei QC9 alleviates hyperglycaemia in a high-fat diet and streptozotocin-induced type 2 diabetes mellitus mice via the microbiota-gut-liver axis
点击查看 >>
Author：
Mengling Chen, Pengyuan Pan, Hongyan Zhang, Rao Li, Dayong Ren, Bin Jiang
IF：
5.1000
Publish_to：
Food & Function
PMID：
38984868
Self-Pumping Janus Hydrogel with Aligned Channels for Accelerating Diabetic Wound Healing
点击查看 >>
Author：
Wu-yi Xiao, Xi Liu, Wenbo Wang, Xiaobin Zhang, Yuzhe Wang, Jinze Lan, Baoshi Fan, Lianxin Shi, Xizi Wan, Shutao Wang
IF：
5.0060
Publish_to：
MACROMOLECULAR RAPID COMMUNICATIONS
PMID：
36459585
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor
点击查看 >>
Author：
Zhiyi Liu, Wei Hua, Sinan Jin, Yueying Wang, Yuxin Pang, Benshuai Wang, Nan Zhao, Yuejia Song, Jiping Qi
IF：
5.0000
Publish_to：
EUROPEAN JOURNAL OF PHARMACOLOGY
PMID：
38341077
Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats
点击查看 >>
Author：
Iheagwam Franklyn Nonso, Iheagwam Olawumi Toyin, Onuoha Michael Kemjika, Ogunlana Olubanke Olujoke, Chinedu Shalom Nwodo
IF：
4.9960
Publish_to：
Scientific Reports
PMID：
35739183
Pathogenic Role of Endoplasmic Reticulum Stress in Diabetic Corneal Endothelial Dysfunction
点击查看 >>
Author：
Chen Chen, Bin Zhang, Junfa Xue, Zongyi Li, Shengqian Dou, Huilin Chen, Qun Wang, Mingli Qu, Huifeng Wang, Yuan Zhang, Luqin Wan, Qingjun Zhou, Lixin Xie
IF：
4.9250
Publish_to：
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
PMID：
35238867
Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis
点击查看 >>
Author：
Li Tianrong, Yang Jingjing, Tan Anjun, Chen Hewen
IF：
4.8000
Publish_to：
Diabetology & Metabolic Syndrome
PMID：
37993958
Flavonoid-Rich Extracts from Chuju (Asteraceae Chrysanthemum L.) Alleviate the Disturbance of Glycolipid Metabolism on Type 2 Diabetic Mice via Modulating the Gut Microbiota
点击查看 >>
Author：
Yu Yin, Wen Nie, Zheng-Quan Tang, Shuang-Jie Zhu
IF：
4.7000
Publish_to：
Foods
PMID：
40077469
Self-Assembling Peptide SCIBIOIII Hydrogel for Three-Dimensional Cell Culture That Promotes Wound Healing in Diabetic Mice
点击查看 >>
Author：
Lu He, Shijian Lan, Qingfeng Cheng, Zhongli Luo, Xuemei Lin
IF：
4.6000
Publish_to：
Gels
PMID：
37102877
Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease
点击查看 >>
Author：
Qing Fang, Binjie Zheng, Na Liu, Jinfeng Liu, Wenhui Liu, Xinyi Huang, Xiangchang Zeng, Lulu Chen, Zhenyu Li, Dongsheng Ouyang
IF：
4.5660
Publish_to：
Frontiers in Physiology
PMID：
34220546
3-Hydroxy-3-methylglutaryl-CoA synthase 2 facilitates erectile dysfunction via inhibiting autophagy by enhancing the mammalian target of rapamycin pathway in type 1 diabetic mellitus rats
点击查看 >>
Author：
Zhiqiang Dai, Yang Zeng, Xiao Tan, Tao Zhou, Xiong Li, Qingfu Deng
IF：
4.5000
Publish_to：
Andrology
PMID：
38273709
Marrow mesenchymal stem cell mediates diabetic nephropathy progression via modulation of Smad2/3/WTAP/m6A/ENO1 axis
点击查看 >>
Author：
Yihua Bai, Lilan Huang, Yang Fan, Yaling Li
IF：
4.4000
Publish_to：
FASEB JOURNAL
PMID：
38847786
The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes
点击查看 >>
Author：
Yunyi Wang, Zhaolan Wei, Ke Xu, Xuan Wang, Xiao Gao, Qi Han, Shuwei Wang, Mingqing Chen
IF：
4.3000
Publish_to：
FOOD AND CHEMICAL TOXICOLOGY
PMID：
36736609
CMD-05, a novel promising clinical anti-diabetic drug candidate, in vivo and vitro studies
点击查看 >>
Author：
Jie Ma, Huan Li, Xiangnan Hu, Lu Yang, Qi Chen, Co
IF：
4.2590
Publish_to：
Scientific Reports 7, Article number: 46628 (2017)
PMID：
28406239
Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model
点击查看 >>
Author：
Qin Wencong, Liu Kaibin, Su Hongjie, Hou Jun, Yang Shenghui, Pan Kaixiang, Yang Sijie, Liu Jie, Zhou Peilin, Lin Zhanming, Zhen Puxiang, Mo Yongjun, Fan Binguang, Li Zhenghui, Kuang Xiaocong, Nie Xinyu, Hua Qikai
IF：
4.2000
Publish_to：
EUROPEAN JOURNAL OF MEDICAL RESEARCH
PMID：
38449025
c-Casitas b-Lineage Lymphoma Downregulation Improves the Ability of Long-term Cultured Mesenchymal Stem Cells for Promoting Angiogenesis and Diabetic Wound Healing
点击查看 >>
Author：
Chengcheng Shen, Yuangang Lu, Jianghe Zhang, Yujie Li, Yiming Zhang, Dongli Fan
IF：
4.0640
Publish_to：
CELL TRANSPLANTATION
PMID：
33588607
Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats
点击查看 >>
Author：
Abdulbaset Al-Romaima, Xiong Guan, Xihui Qin, Yinan Liao, Guiming Qin, Shixiong Tang, Jie Feng
IF：
4.0610
Publish_to：
Journal of Diabetes Research
PMID：
36484062
DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice
点击查看 >>
Author：
Tie-Feng Yao, Zhi-Yun Wang, Lu Sun, Sheng-Xue Yu, Hong Dan Yu, Zheng-Zhong Yang, Wan-Ze Li, Lin Niu, Die Sun, Ya-Hui Shi, Jun-Qi Li, Wen-Qiang Liu, Xue-Zheng Liu, Zhong-Fu Zuo
IF：
4.0000
Publish_to：
JOURNAL OF BIOLOGICAL CHEMISTRY
PMID：
39730060
Sorafenib decreases glycemia by impairing hepatic glucose metabolism
点击查看 >>
Author：
Ma Jingjing, Sui Fang, Liu Yan, Yuan Mengmeng, Dang Hui, Liu Rui, Shi Bingyin, Hou Peng
IF：
3.9250
Publish_to：
ENDOCRINE
PMID：
36205915
TFEB attenuates hyperglycemia-induced retinal capillary endothelial cells injury via autophagy regulation
点击查看 >>
Author：
Yanhua Cheng, Huimin Fan, Kangcheng Liu, Jingying Liu, Hua Zou, Zhipeng You
IF：
3.9000
Publish_to：
CELL BIOLOGY INTERNATIONAL
PMID：
36807611
The novel function of citronellal for antidiabetic cardiomyopathy
点击查看 >>
Author：
Qiu Yue, Meng Liuwei, Chao Chunyan, Wang Ling, Wang Yang, Liu Tianheng, Fu Yutian, Li Yue, Song Yuting, Guo Yaqi, Niu Qianqian, Zhang Jie, Yin Yaling, Li Peng
IF：
3.8480
Publish_to：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
PMID：
34596208
Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes-Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative Stress, Apoptosis, and Inflammation
点击查看 >>
Author：
Mojtaba Sargazi, Narges Karbalaei, Saied Karbalay-Doust, Sara Keshtgar, Zohre Aghaei
IF：
3.8000
Publish_to：
Stem Cells International
PMID：
39391856
Ursolic acid regulates gut microbiota and corrects the imbalance of Th17/Treg cells in T1DM rats
点击查看 >>
Author：
Weiwei Chen, Yingying Yu, Yang Liu, ChaoJie Song, HuanHuan Chen, Cong Tang, Yu Song, Xiaoli Zhang
IF：
3.7520
Publish_to：
PLoS One
PMID：
36327331
Improved oral delivery of insulin by PLGA nanoparticles coated with 5β-cholanic acid conjugated glycol chitosan
点击查看 >>
Author：
Weizhi Wang, Chenggong Yu, Fangfang Zhang, Yuxuan Li, Bo Zhang, Jie Huang, Zhijun Zhang, Liang Jin
IF：
3.7150
Publish_to：
Biomedical Materials
PMID：
34571498
Autophagy reduces aortic calcification in diabetic mice by reducing matrix vesicle body-mediated IL-1β release
点击查看 >>
Author：
Xiaolei Sun, Yang Zheng, Linzhuo Xie, Yuanqun Zhou, Runyu Liu, Yarong Ma, Ming Zhao, Yong Liu
IF：
3.7000
Publish_to：
EXPERIMENTAL CELL RESEARCH
PMID：
37774764
Hypoglycemic and hypolipidemic effects of polysaccharide isolated from Sphacelotheca sorghi in diet-streptozotocin-induced T2D mice
点击查看 >>
Author：
Xin Fu, Mengxue Song, Ming Lu, Mengxi Xie, Lin Shi
IF：
3.6930
Publish_to：
JOURNAL OF FOOD SCIENCE
PMID：
35275401
Aqueous extract of Polygonatum sibiricum ameliorates glucose and lipid metabolism via PI3K/AKT signaling pathway in high-fat diet and streptozotocin-induced diabetic mice
点击查看 >>
Author：
Guangjun Wang, Zhengxiang Liu, Di Liang, Jinchuan Yu, Ting Wang, Fuding Zhou, Wenjun Chen
IF：
3.6540
Publish_to：
JOURNAL OF FOOD BIOCHEMISTRY
PMID：
36226981
Total Water–Soluble Flavonoids From Lithocarpus litseifolius (Hance) Chun (Sweet Tea) Improve Glucose Homeostasis Through Multitarget Signalling in GDM Mice
点击查看 >>
Author：
Junfei Xu, Fenfang Zhang, Huanhuan Li, Pan Li, Junying Zeng, Xianjin Wu, Rong Zhou, Chunyan Yang, Juzuo Zhang
IF：
3.6000
Publish_to：
Journal of Diabetes Research
PMID：
39568571
Downregulation of circular RNA circDOCK7 identified from diabetic rats after sleeve gastrectomy contributes to hepatocyte apoptosis through regulating miR-139–3p and MCM3
点击查看 >>
Author：
Linchuan Li, Shuohui Dong, Songhan Li, Qian Xu, Shuo Wang, Yacheng Xiong, Yugang Cheng, Mingwei Zhong, Guangyong Zhang, Sanyuan Hu
IF：
3.5750
Publish_to：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
PMID：
33640606
Low-intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR-449a/DLL1 signaling in diabetic rats
点击查看 >>
Author：
Nie Han, Shaodan Cheng, Ye Jin, Guanheng Li, Huan Wang, Lin Jin
IF：
3.5000
Publish_to：
NEUROGASTROENTEROLOGY AND MOTILITY
PMID：
38873849
Hyperglycemia induces corneal endothelial dysfunction through attenuating mitophagy
点击查看 >>
Author：
Chen Chen, Qingjun Zhou, Zongyi Li, Haoyun Duan, Yameng Liu, Luqin Wan, Huifeng Wang, Lixin Xie
IF：
3.4670
Publish_to：
EXPERIMENTAL EYE RESEARCH
PMID：
34951999
Effect of PPARγ on oxidative stress in diabetes-related dry eye
点击查看 >>
Author：
Jing Wang, Shuangping Chen, Xiuxiu Zhao, Qian Guo, Ruibo Yang, Chen Zhang, Yue Huang, Lechong Ma, Shaozhen Zhao
IF：
3.4000
Publish_to：
EXPERIMENTAL EYE RESEARCH
PMID：
37169280
Mode of cell death in the penile cavernous tissue of type 1 diabetes mellitus rats
点击查看 >>
Author：
Li Jing, Jiang Qilan, Jiang Jun, Jiang Rui
IF：
3.3000
Publish_to：
Journal of Sexual Medicine
PMID：
38972660
Downregulation of Salusin-β protects renal tubular epithelial cells against high glucose-induced inflammation, oxidative stress, apoptosis and lipid accumulation via suppressing miR-155-5p
点击查看 >>
Author：
Hongmei Chen, Genjuan Jin
IF：
3.2690
Publish_to：
Bioengineered
PMID：
34482798
Artesunate protects pancreatic β-cells from streptozotocin-induced diabetes via inhibition of the NLRP3/caspase-1/GSDMD pathway
点击查看 >>
Author：
Jingya Yuan, Shipeng Li, Huifang Peng, Yujin Ma, Liping Li, Liujun Fu, Jie Liu, Hongwei Jiang
IF：
3.2550
Publish_to：
GENERAL AND COMPARATIVE ENDOCRINOLOGY
PMID：
35671834
Potential Molecular Mechanism of Yishen Capsule in the Treatment of Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking
点击查看 >>
Author：
Yaling Hu, Shuang Liu, Wenyuan Liu, Ziyuan Zhang, Yuxiang Liu, Sufen Li, Dalin Sun, Guang Zhang, Jingai Fang
IF：
3.2490
Publish_to：
Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
PMID：
35378831
miR-31 ameliorates type 2 diabetic vascular damage through up-regulation of hypoxia-inducible factor-1α/vascular endothelial growth factor-A
点击查看 >>
Author：
Yuan Fu, Ruochen Du, Yufei Wang, Yitong Yuan, Yujuan Zhang, Chunfang Wang, Xuanping Zhang
IF：
3.2000
Publish_to：
Journal of Diabetes Investigation
PMID：
37394926
Transcriptome and Pathway Analysis Reveals that Adipose-derived Stem Cells Target Inflammatory Factors and Delay the Progression of Diabetic Liver Disease
点击查看 >>
Author：
Yanli Hou, Guoliang Gao, Wenyu Ding, Peishan Wu, Changqing Liu, Dong Lin, Deshan Liu, Xiaolei Wang
IF：
3.1000
Publish_to：
Frontiers in Bioscience-Landmark
PMID：
38179756
Hyperglycemia-depleted glutamine contributes to the pathogenesis of diabetic corneal endothelial dysfunction
点击查看 >>
Author：
Mengmeng Yu, Huilin Chen, Chen Chen, Can Zhao, Qingjun Zhou, Lixin Xie, Ting Wang
IF：
3.0000
Publish_to：
EXPERIMENTAL EYE RESEARCH
PMID：
39396694
Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice
点击查看 >>
Author：
Tianyang Wang, Xuejiao Wen, Ziwen Zhang, Minjuan Xie, Jie Zhou
IF：
2.9030
Publish_to：
HUMAN & EXPERIMENTAL TOXICOLOGY
PMID：
34649470
Intra-gastrically administration of Stevia and particularly Nano-Stevia reversed the hyperglycemia, anxiety, and memory impairment in streptozotocin-induced diabetic rats
点击查看 >>
Author：
Fatemeh Khakpai, Maryam Naseroleslami, Marzieh Moheb-Alian, Elham Ghanimati, Faezeh Abdollah-pour, Neda Mousavi-Niri
IF：
2.9000
Publish_to：
PHYSIOLOGY & BEHAVIOR
PMID：
36716984
Metformin and Gegen Qinlian Decoction boost islet α-cell proliferation of the STZ induced diabetic rats
点击查看 >>
Author：
Xu Li, Jois Shreyas, Cui Hongliang
IF：
2.8380
Publish_to：
BMC Complementary Medicine and Therapies
PMID：
35858880
Nano-Stevia reduces the liver injury caused by streptozotocin (STZ)-induced diabetes in rats by targeting PEPCK/GCK genes, INSR pathway and apoptosis
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Author：
Mousavi-Niri Neda, Khakpai Fatemeh, Moheb-Alian Marzieh, Ghanimati Elham, Abdollah-Pour Faezeh, Naseroleslami Maryam
IF：
2.8000
Publish_to：
Journal of Diabetes and Metabolic Disorders
PMID：
37975120
Liraglutide ameliorates myocardial damage in experimental diabetic rats by inhibiting pyroptosis via Sirt1/AMPK signaling
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Author：
Zhe Zhang, Xing Wang, Linlin Yang, Linquan Yang, Huijuan Ma
IF：
2.6990
Publish_to：
Iranian Journal of Basic Medical Sciences
PMID：
35096293
FKN/NR Signaling Pathway Regulates Hippocampal Inflammatory Responses: the Survival of Hippocampal Neurons in Diabetic Rats with Chronic Unpredictable Mild Stress
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Author：
Zhuo Liu, Hongqing Zhao, Jian Liu, Yuanshan Han, Yuhong Wang
IF：
2.6500
Publish_to：
Evidence-based Complementary and Alternative Medicine
PMID：
36072409
Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy
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Author：
Yuxiang Liu, Wenyuan Liu, Ziyuan Zhang, Yaling Hu, Xiaodong Zhang, Yanyan Sun, Qingqing Lei, Dalin Sun, Ting Liu, Yanjun Fan, Hui Li, Wujie Ding, Jingai Fang
IF：
2.6060
Publish_to：
RENAL FAILURE
PMID：
33427556
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway
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Author：
Xu Lei, Zhang Chunfang, Bao Jiawu, Han Guozhu, Wang Changyuan, Cai Yuanqing, Xu Gang, Sun Huijun, Liu Mozhen
IF：
2.6000
Publish_to：
CELL BIOCHEMISTRY AND BIOPHYSICS
PMID：
38261247
Effects of continuous subcutaneous insulin infusion on the microstructures, mechanical properties and bone mineral compositions of lumbar spines in type 2 diabetic rats
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Author：
Hu Xiaorong, Gong He, Hou Aiqi, Wu Xiaodan, Shi Peipei, Zhang Yingying
IF：
2.5620
Publish_to：
BMC MUSCULOSKELETAL DISORDERS
PMID：
35637472
Atractylodes chinensis volatile oil up-regulated IGF-1 to improve diabetic gastroparesis in rats
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Author：
Hongzeng Li, Yitong Wang, Yuxin Tian, Feiyue Tian, Zhiyang Xing, Yunfei Wang, Meixing Yan, Yanling Gong
IF：
2.5320
Publish_to：
Iranian Journal of Basic Medical Sciences
PMID：
35656073
Study on the role and mechanism of Tan IIA in Alzheimer’s disease based on CREB-BDNF-TrkB pathway
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Author：
Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou
IF：
2.5000
Publish_to：
NEUROSCIENCE LETTERS
PMID：
38616003
Tetrathiomolybdate Partially Alleviates Erectile Dysfunction of Type 1 Diabetic Rats Through Affecting Ceruloplasmin/eNOS and Inhibiting Corporal Fibrosis and Systemic Inflammation
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Author：
Yinghao Yin, Jingxuan Peng, Jun Zhou, Hanfei Chen, Dongyi Peng, Dongjie Li, Yu Gan, Guangming Yin, Yuxin Tang
IF：
2.4910
Publish_to：
Sexual Medicine
PMID：
34818604
Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue
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Author：
Zhi Peng, Hui Wang, Jiaoyun Zheng, Hui Chen, Jie Wang, Horst Christian Weber, Lin Yuan, Xiaoqun Qin, Yang Xiang, Chi Liu, Ming Ji, Huijun Liu, Xiangping Qu
IF：
2.4000
Publish_to：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
PMID：
39155151
Cell division cycle 42 attenuates high glucose-treated renal tubular epithelial cell apoptosis, fibrosis, and inflammation, but activates the PAK1/AKT pathway
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Author：
Zheng Shanshan, Zhao Na, Feng Chuwen, Ma Jian
IF：
2.3000
Publish_to：
Clinical and Experimental Nephrology
PMID：
38416339
Anti-inflammation properties of resveratrol in the detrusor smooth muscle of the diabetic rat
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Author：
Xu Feihong, Du Huifang, Hou Jun, Liu Jingxuan, Li Ning
IF：
2.2660
Publish_to：
INTERNATIONAL UROLOGY AND NEPHROLOGY
PMID：
35943662
Aucubin protects against retinal ganglion cell injury in diabetic rats via inhibition of the p38MAPK pathway.
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Author：
Mei Feng, Xia Jiang, Qingsong Zhang, Qifeng Wang, Chunyan She, Zudan Li
IF：
2.2000
Publish_to：
American Journal of Translational Research
PMID：
36915767
Interference of periostin attenuates pathological changes, proinflammatory markers and renal fibrosis in diabetic kidney injury
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Author：
Duan Xiaoting, Chen Cheng, Liu Xiaoli, Wang Taoxia, Feng Shuning, Li Jianwei, Li Guiying
IF：
2.1000
Publish_to：
Genes & Genomics
PMID：
37248423
Scutellarin Alleviates Diabetic Retinopathy via the Suppression of Nucleotide-Binding Oligomerization Domain (NOD)-Like Receptor Pyrin Domain Containing Protein 3 Inflammasome Activation
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Author：
Lina Yang, Zheming Li, Jian Fang
IF：
2.0000
Publish_to：
CURRENT EYE RESEARCH
PMID：
38014534
Shenling Guchang prescription ameliorates intestinal barrier inflammation in gestational diabetes rats via TLR4/NF-κB pathway
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Author：
Manling Li, Lisha Li, Xingman Liu, Tao Yang, Jingyun Gao, Anqin Wu, Zhaozhao Hua, Ling Wang
IF：
1.9000
Publish_to：
Drug Discoveries and Therapeutics
PMID：
39662954
Glucometabolic-Related Genes as Diagnostic Biomarkers and Therapeutic Targets for Alzheimer’s Disease and Type 2 Diabetes Mellitus: A Bioinformatics Analysis
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Author：
Shuo Liu, He Chen, Xiao-Dong He, Xiao-Ou Yang
IF：
1.7000
Publish_to：
Neurology Research International
PMID：
38595695
Oral administration of nano-tyrosol reversed the diabetes-induced liver damage in streptozotocin-induced diabetic rats
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Author：
Jafari-Rastegar Nima, Hosseininia Haniyeh-Sadat, Jalilvand Elahe, Naseroleslami Maryam, Khakpai Fateme, Mousavi-Niri Neda
IF：
1.6000
Publish_to：
Journal of Diabetes and Metabolic Disorders
PMID：
37255797
Ameliorative effect of lixisenatide on diabetic cardiovascular damage and its enhancement via ticagrelor co-administration in rats: possible role of eNOS and NrF2 /HO-1 signaling
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Author：
Sleem M., Aboubakr E.M., Mohamed W.R., Messiha B.A.S., Taye A.
IF：
1.5000
Publish_to：
PHARMAZIE
PMID：
38877681
Correlation Between Gut Microbiota Composition and Serum Interleukin 17 (IL-17) in Mice With Type 2 Diabetes and Experimental Periodontitis
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Author：
Chaolun Mo, Mingkun Huang, Fuhua Yan, Minghui Song, Jiabing Fan, Junmei Zhang
IF：
1.0000
Publish_to：
Cureus Journal of Medical Science
PMID：
39211822
技术问答
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注意：
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我的链脲佐菌素买了两次都未成模型。什么原因。?2023-06-17 22:27:38
您好，试剂应注意干燥避光保存，现用现配，工作浓度及用量根据不同动物参考相关文献选择或自行摸索，模型不达标者，三天后可补注STZ（以10mg-20mg/kg体重剂量腹腔注射），也很容易成模，或让血糖恢复正常后再常规剂量注射；但要达到理想的效果，往往是恢复到正常状态下重新造模，其他情况具体问题具体分析。
你好，链脲佐菌素 STZ现配现用的话，怎么溶解呢？需要溶解到多少ml1%的柠檬酸盐?2022-10-29 23:33:06
您好，可以使用柠檬酸缓冲液进行配置，参考溶解性为10mg/ml，具体工作浓度需要根据实验目的要求查阅相关文献进行参考。