CAS |
No.760-78-1 |
中文名称 |
DL-正缬氨酸 |
英文名称 |
DL-Norvaline |
别名 |
H-DL-Nva-OH;2-Aminovaleric acid;α-Aminopentanoic acid |
分子式 |
C5H11NO2 |
分子量 |
117.15 |
溶解性 |
Soluble in Water |
纯度 |
≥98% |
外观(性状) |
White to off-white Solid |
储存条件 |
Powder:2-8℃,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year |
MDL |
MFCD00064420 |
SMILES |
CCCC(C(=O)O)N |
InChIKey |
SNDPXSYFESPGGJ-UHFFFAOYSA-N |
InChI |
InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8) |
PubChem CID |
824 |
背景说明 |
是一种氨基酸。 |
生物活性 |
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase. |
IC50 |
Human Endogenous Metabolite |
In Vitro |
DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2]. |
细胞实验 |
A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A.actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A.actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1]. |
数据来源文献 |
[1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50. [2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200. |
规格 |
100mg 250mg 500mg 1g |
单位 |
瓶 |