| CAS |
No.79103-90-5 |
| 中文名称 |
瓜子金皂苷XXXI |
| 英文名称 |
Polygalasaponin XXXI |
| 别名 |
远志皂苷 F |
| 分子式 |
C75H112O36 |
| 分子量 |
1589.67 |
| 溶解性 |
Soluble in DMSO |
| 纯度 |
HPLC≥95% |
| 外观(性状) |
Solid |
| 储存条件 |
Powder: -20℃，2 years |
| MDL |
MFCD29904545 |
| SMILES |
CC1C(C(C(C(O1)OC(=O)C23CCC(CC2C4=CCC5C(C4(CC3)CO)(CCC6C5(CC(C(C6(C)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)C)C)(C)C)OC8C(C(C(C(O8)C)OC9C(C(C(CO9)O)OC1C(C(C(CO1)O)O)O)O)OC1C(C(CO1)(CO)O)O)O)O)OC(=O)C=CC1=CC(=C(C(=C1)OC)OC)OC |
| InChIKey |
HDLNHPZHTNFCNP-JJEFWQELSA-N |
| InChI |
InChI=1S/C75H112O36/c1-31-53(105-44(82)14-11-33-21-39(96-8)56(98-10)40(22-33)97-9)50(88)58(109-64-52(90)57(108-66-59(91)75(95，29-78)30-101-66)54(32(2)102-64)106-62-51(89)55(38(81)27-100-62)107-61-48(86)45(83)37(80)26-99-61)65(103-31)111-68(94)73-18-17-69(3，4)23-35(73)34-12-13-42-70(5)24-36(79)60(110-63-49(87)47(85)46(84)41(25-76)104-63)72(7，67(92)93)43(70)15-16-71(42，6)74(34，28-77)20-19-73/h11-12，14，21-22，31-32，35-38，41-43，45-55，57-66，76-81，83-91，95H，13，15-20，23-30H2，1-10H3，(H，92，93)/b14-11+/t31-，32+，35+，36+，37+，38-，41-，42-，43-，45+，46-，47+，48-，49-，50+，51-，52-，53+，54+，55+，57+，58-，59+，60+，61+，62+，63+，64+，65+，66+，70-，71-，72+，73+，74+，75-/m1/s1 |
| PubChem CID |
10701737 |
| 靶点 |
Others |
| 通路 |
Others |
| 背景说明 |
是鼻内注射流感 HA 疫苗中佐剂的有效成分。 |
| 生物活性 |
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1]. |
| In Vitro |
Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash， whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus[1].Polygalasaponin XXXI (Onjisaponin F) (1 or 10 μg/mL) also induces ChAT mRNA level in rat basal forebrain cells[2]. |
| In Vivo |
Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1]. |
| 数据来源文献 |
[1]. T Nagai， et al. Onjisaponins， From the Root of Polygala Tenuifolia Willdenow， as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34.
[2]. T Yabe， et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia， Constituents of Kampo (Japanese Herbal) Medicine， Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14. |
| 规格 |
5mg |
| 单位 |
瓶 |
中文
英语
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