| 基因名 |
TRPC4AP |
| 别名 |
C20orf188，TRRP4AP |
| 英文名称 |
Recombinant human TRPC4AP protein |
| 全名 |
transient receptor potential cation channel，subfamily C，member 4 associated protein |
| 外观(性状) |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
| 纯度 |
≥85% by SDS-PAGE. |
| 储存条件 |
Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
| 运输条件 |
The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below. |
| 浓度 |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q8TEL6 |
| Gene ID |
26133 |
| 分子量 |
38.8kDa |
| 区间范围 |
1-350aa |
| 背景说明 |
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948). The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948). The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca2+ storage reduction in response to CHRM1 (By similarity). |
| 应用 |
Immunology research |
| 来源 |
E.coli |
| 纯化方法 |
NI-NTA affinity purification |
| 溶剂 |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 内毒素 |
Not measured |
| 生物活性 |
NO |
| 标签信息 |
With a 6×His tag at the N/C-terminus. |
| 规格 |
10ug 50ug 100ug 1mg |
| 单位 |
支 |
| 属性分类 |
重组抗原 |
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