CAS |
No.1013750-77-0 |
英文名称 |
ML-030 |
别名 |
CID-11757146 |
分子式 |
C20H20N4O4S |
分子量 |
412.46 |
溶解性 |
Soluble in DMSO |
纯度 |
≥98% |
外观(性状) |
Solid |
储存条件 |
Powder:2-8℃,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year |
SMILES |
COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC |
InChIKey |
DZAUSKKPHXFGNN-UHFFFAOYSA-N |
InChI |
InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3 |
PubChem CID |
17757146 |
靶点 |
PDE4 |
通路 |
Metabolic Enzyme&Protease |
背景说明 |
ML-030 是一种有效的 PDE4 抑制剂。 |
生物活性 |
ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.[1] |
IC50 |
IC50: 6.7nM(PDE4A);12.9nM(PDE4A1);48.2nM(PDE4B1);37.2(PDE4B2)nM;452(PDE4C1)nM;49.2(PDE4D2)nM[1] |
In Vitro |
ML-030 is potent in cell-based assay with an EC50 value of 18.7 nM[1]. |
数据来源文献 |
[1]. Skoumbourdis AP, et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92. |
规格 |
5mg 10mg 25mg 50mg |
单位 |
瓶 |