| CAS |
No.34161-24-5 |
| 中文名称 |
非哌西特 |
| 英文名称 |
Fipexide |
| 分子式 |
C20H21ClN2O4 |
| 分子量 |
388.84 |
| 溶解性 |
Soluble in DMSO(Need ultrasonic) |
| 纯度 |
≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 251-857-4 |
| MDL |
MFCD00865385 |
| SMILES |
C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C(=O)COC4=CC=C(C=C4)Cl |
| InChIKey |
BFUJHVVEMMWLHC-UHFFFAOYSA-N |
| InChI |
InChI=1S/C20H21ClN2O4/c21-16-2-4-17(5-3-16)25-13-20(24)23-9-7-22(8-10-23)12-15-1-6-18-19(11-15)27-14-26-18/h1-6，11H，7-10，12-14H2 |
| PubChem CID |
3351 |
| 靶点 |
Dopamine Transporter;adenylate cyclase |
| 通路 |
Neuronal Signaling;GPCR & G Protein |
| 背景说明 |
Fipexide是一种哌嗪类的抗精神化合物,，通过多巴胺能神经传递对认知表现出积极的作用，可用于老年痴呆的相关研究。此外，Fipexide 可以抑制纹状体腺苷酸环化酶 (adenylate cyclase) 活性。 |
| 生物活性 |
Fipexide， a parachloro-phenossiacetic acid derivative， is an orally active nootropic agent. Fipexide reduces striatal adenylate cyclase activity. Fipexide has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide is used for senile dementia research. Fipexide acts as a chemical inducer in callus formation， shoot regeneration and Agrobacterium infection[1][2]. |
| In Vitro |
FPX was shown to act as a chemical inducer in callus formation， shoot regeneration and Agrobacterium infection. With regards to morphology， the cellular organization of FPX - induced calli differed from those produced under auxin/cytokinin conditions.Microarray analysis revealed that the expression of approximately 971 genes was up - regulated 2 - fold after a 2 d FPX treatment compared with non - treated plants. Among these 971 genes， 598 genes were also induced by auxin/cytokinin， whereas 373 genes were specifically expressed upon FPX treatment only.FPX can promote callus formations in rice， poplar， soybean， tomato and cucumber， and thus can be considered a useful tool for revealing the mechanisms of plant development and for use in plant transformation technologies.[2] |
| In Vivo |
Deficit in active and inhibitory avoidance behaviour has been observed in pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy.In the present study we examined the effect of the nootropic drugs piracetam and fipexide on memory deficit induced by PTZ - kindling in shuttle - box - and step - down - trained rats. The retention in piracetam - and fipexide - treated animals was significantly improved compared to the kindled controls.The favourable effect of nootropic drugs in cases of amnesia provoked by PTZ - kindling might be of interest in clinical practice.[3].Animal Model: Kindled rats[3];Dosage:10 mg/kg；Administration:Orally; 5-10 days；Result:Completely abolishes the memory deficit produced by kindling.Antagonized the amnestic effect of Pentylenetetrazole (PTZ) -kindling. |
| 数据来源文献 |
[1]. A Marino， et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87.
[2]. Takeshi Nakano， et al.FPX is a Novel Chemical Inducer that Promotes Callus Formation and Shoot Regeneration in Plants. Plant Cell Physiol. 2018 Aug 1;59(8):1555-1567.
[3]. M G Genkova-Papazova， et al. Piracetam and fipexide prevent PTZ-kindling-provoked amnesia in rats. Eur Neuropsychopharmacol. 1996 Nov;6(4):285-90. |
| 规格 |
100mg 500mg 1g |
| 单位 |
瓶 |
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