CAS |
No.5273-86-9 |
中文名称 |
β-细辛脑 |
英文名称 |
Beta-asarone |
别名 |
(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑;Cis-Isoasarone;Cis-Asarone;Cis-Isoelemicin |
分子式 |
C12H16O3 |
分子量 |
208.25 |
溶解性 |
Soluble in DMSO |
纯度 |
≥98% |
外观(性状) |
Liquid |
储存条件 |
Store at 2-8℃,2 years |
密度 |
1.073g/mL |
EC |
EINECS 226-096-6 |
MDL |
MFCD00009281 |
SMILES |
CC=CC1=CC(=C(C=C1OC)OC)OC |
InChIKey |
RKFAZBXYICVSKP-WAYWQWQTSA-N |
InChI |
InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3/b6-5- |
PubChem CID |
5281758 |
靶点 |
Others |
通路 |
Others |
背景说明 |
是石菖蒲中的主要成分,可透过血脑屏障,具有免疫抑制、中枢神经系统抑制等活性,可用于帕金森的相关研究。 |
生物活性 |
Beta-asarone 是石菖蒲中的主要成分,可透过血脑屏障,具有神经保护作用,可预防帕金森病。[1] |
In Vitro |
β-asarone elevated the viability of cells exposed to MPP+. Either overexpressed MALAT1 or α-synuclein could canceled the protective effect of β-asarone on cell viability.[1] |
In Vivo |
β-Asarone significantly increased the TH+ cells number and decreased the expression levels of MALAT1 and α-synuclein in midbrain tissue of PD mice.[1] |
数据来源文献 |
[1]. Zhang QS,et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression. Biomed Pharmacother. 2016 Oct;83:153-159. |
规格 |
1mg 5mg 10mg 25mg 50mg |
单位 |
瓶 |