| CAS |
No.51-15-0 |
| 中文名称 |
氯解磷定 |
| 英文名称 |
Pralidoxime Chloride |
| 别名 |
2-PAM (chloride);吡啶醛肟甲氯;2-Pyridinealdoxime methochloride |
| 分子式 |
C7H9ClN2O |
| 分子量 |
172.61 |
| 溶解性 |
Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 |
≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 200-080-9 |
| MDL |
MFCD00011981 |
| SMILES |
C[N+]1=CC=CC=C1C=NO.[Cl-] |
| InChIKey |
HIGSLXSBYYMVKI-UHFFFAOYSA-N |
| InChI |
InChI=1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H，1H3;1H |
| PubChem CID |
135445761 |
| 靶点 |
AChE |
| 通路 |
Neuronal Signaling |
| 背景说明 |
是一种有效的乙酰胆碱酯酶 (AChE) 的再激活剂；通过肟部分对结合神经毒剂磷中心的亲核攻击，重新激活受神经毒剂抑制的 AChE。 |
| 生物活性 |
Pralidoxime Chloride 是一种强效的乙酰胆碱酯酶（AChE）再活化剂，也是有机磷中毒的解毒剂。[1-2] |
| In Vivo |
After pralidoxime were administered intramuscularly，diethylparaoxon induced clinical symptoms and a decrease in respiratory frequency. By administering an equipotent dose of diethylparaoxon to rats，a 150 mg kg-1 dose of pralidoxime administered alone completely reversed diethylparaoxon-induced respiratory toxicity in mice.[2] |
| 动物实验 |
A dose of diethylparaoxon corresponding to 50% of the median lethal dose was administered subcutaneously to male F1B6D2 mice. Ascending single pralidoxime doses of 10，50-100 and 150 mg kg-1 were administered intramuscularly 30 min after diethylparaoxon administration. Ventilation at rest was assessed using whole-body plethysmography and mice temperature was assessed using infrared telemetry.[2] |
| 数据来源文献 |
[1]. Cadieux CL，et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016 Nov 25;259(Pt B):133-141.
[2]. Houzé P，et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018 Apr;46(2):131-138. doi: 10.5152/TJAR.2018.29660. Epub 2018 Apr 1. |
| 规格 |
100mg |
| 单位 |
瓶 |
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