| CAS |
No.590-63-6 |
| 中文名称 |
氯贝胆碱 |
| 英文名称 |
Bethanechol Chloride |
| 别名 |
Carbamyl-β-methylcholine chloride;Myocholine;(±)-Bethanechol;Urecholine |
| 分子式 |
C7H17ClN2O2 |
| 分子量 |
196.68 |
| 溶解性 |
Soluble in Water/DMSO(Need ultrasonic) |
| 纯度 |
≥98% |
| 外观(性状) |
White to off-white Solid |
| 储存条件 |
Powder:2-8℃，2 years;Insolvent(母液):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 209-686-8 |
| MDL |
MFCD00055224 |
| SMILES |
CC(C[N+](C)(C)C)OC(=O)N.[Cl-] |
| InChIKey |
XXRMYXBSBOVVBH-UHFFFAOYSA-N |
| InChI |
InChI=1S/C7H16N2O2.ClH/c1-6(11-7(8)10)5-9(2，3)4;/h6H，5H2，1-4H3，(H-，8，10);1H |
| PubChem CID |
11548 |
| 靶点 |
mAChR |
| 通路 |
Neuronal Signaling;GPCR & G Protein |
| 背景说明 |
是一种选择性毒蕈碱受体激动剂。 |
| 生物活性 |
Bethanechol Chloride 是一种选择性毒蕈碱受体 (mAChR) 激动剂，对烟碱受体没有效果。[1-2] |
| In Vitro |
On the microelectrode array(MEA)，ACh(0.3-300 μM)and bethanechol(0.3-300 μM)significantly reduced ileal pacemaker potentials. In the organ bath，ACh(300 nM)and bethanechol(30 μM)induced ileal tonic contractions，while inhibiting basal spontaneous contractions at 300 μM.[2] |
| In Vivo |
The use of 50 mg oral bethanechol significantly increased(P<0.05)the esophageal contraction pressures at 5 and 10 cm above the lower esophageal sphincter(LES).[1] Acute administration of the parasympathomimetic agent，bethanechol，at 2，4，8 and 12 mg/kg body wt，IP，induced drinking and increased urine output of rats in a dose-dependent fashion. The first significant increases in both water intake and urine output above that of controls occurred when 4 mg/kg was administered. Administration of bethanechol(8 mg/kg)to conscious rats was also accompanied by a significant reduction in both mean blood pressure and heart rate that reached minimal levels within 10 min after treatment. Both responses had returned to control level by one hr after treatment.[3] |
| 数据来源文献 |
[1]. Agrawal A，et al. Bethanechol improves smooth muscle function in patients with severe ineffective esophageal motility. J Clin Gastroenterol. 2007 Apr;41(4):366-70.
[2]. Liu JYH，et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G97-G107.
[3]. Fregly MJ，et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17(4):727-32. |
| 规格 |
200mg |
| 单位 |
瓶 |
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