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泊洛沙姆407

CAS:No.9003-11-6

英文名称:Poloxamer 407

分子式:No data available

储存条件:Powder:2-8℃,2 years

泊洛沙姆407
小分子同系列4赠1
货号:
IP9010
品牌:
Solarbio
SKU 北京总部 北京海淀 武汉 广州
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是非离子型表面活性剂,有特殊的反向热胶凝作用,刺激性小,生物相容性好,是一个理想的药物控释材料


使用本产品的案例(仅供参考

In Vivo

Rabbit ( mature female New Zealand white rabbits (weight 2.5 ±0.5 kg);  injected into rabbits with 10 Fr catheter continuously for five days)

The mature female New Zealand white rabbits (weight 2.5 ±0.5 kg) were maintained under standardized laboratory (temperature 20 ± 2℃, relative humidity 45 ± 10%).    Forage and water were qualified.Normal saline, P407 gel, LDH-P407 gel and nonoxinol gel were injected into rabbits with 10 Fr catheter continuously for five days. The rabbits were sacrificed on the sixth day and the vaginal tissues were dissected.

来源文献:Tian W, Han S, Huang X, Han M, Cao J, Liang Y, Sun Y. LDH hybrid thermosensitive hydrogel for intravaginal delivery of anti-HIV drugs. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1234-1240. doi: 10.1080/21691401.2019.1596935. Retraction in: Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):555. PMID: 30966834.    


MiceSPF-grade male SD rats, aged 68 weeks and weighing 160-180 g intraperitoneally injected,10% Poloxam 407 ,at a dose of 0.25 g/kg at an interval of 48 h until Day 14.

In the C group, 10% Poloxam 407 (P-407) (Solarbio, Beijing, China) was intraperitoneally injected at a dose of 0.25 g/kg at an interval of 48 h until Day 14.

来源文献:Wang L, Ren Y, Xu T, Geng J, Yang N, Wang R. Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis. Dig Dis Sci. 2024 Jun;69(6):2123-2131. doi: 10.1007/s10620-024-08412-x. Epub 2024 Apr 12. PMID: 38609542.


备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.

实验图
Wang L,et al.doi: 10.1007/s10620-024-08412-x.
Wang L,et al.doi: 10.1007/s10620-024-08412-x.
注意:
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。
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