产品类型 |
多肽 |
CAS |
No.166188-11-0 |
单字母序列 |
AFLPWHRLF |
三字母序列 |
Ala-Phe-Leu-Pro-Trp-His-Arg-Leu-Phe |
分子式 |
C61H83N15O10 |
分子量 |
1186.43 |
纯度 |
≥98% |
外观(性状) |
冻干粉;Lyophilized powder |
溶解性 |
DMSO:125 mg/mL; *超声助溶; |
盐体系 |
TFA盐;Trifluoroacetate salt |
来源 |
合成;Synthetic |
储存条件 |
Store at -20℃,2 years.(Avoid freeze/thaw cycles) |
背景说明 |
This peptide is a tyrosinase epitope recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL). Therefore it represents a reagent that may be used to generate melanoma-specific T cells for adoptive immunotherapy, as well as in peptide vaccines for HLA-A24+ melanoma patients. |
In Vivo |
Tyrosinase (206-214) is administered intranasally (i.n.; 45 μL; weekly for three weeks) into HLA-A24 transgenic (A24Tg) mice. Tyrosinase (206-214) shows an accumulation of murine CD3+ and CD8+ cells around the bronchioles. All A24Tg immunized with Tyrosinase (206-214) died after lethal A/HK483 infection. |
In Vitro |
Tyrosinase (206-214), human (AFLPWHRLF) can be used to generate melanoma-specific T cells for adoptive immunotherapy, as well as in peptide vaccines for HLA-A24+ melanoma. |
参考文献 |
[1] MelanomaM.P.Bettinotti et al., J. Immunother., 23, 282(2000). |
研究领域 |
肿瘤&癌症 |
规格 |
1mg 5mg 10mg |
单位 |
瓶 |
分类属性 |
目录肽 |