| 基因名 |
TNFSF11 |
| 别名 |
CD254;hRANKL2;ODF;OPGL;OPTB2;Osteoclast differentiation factor;Osteoprotegerin ligand;RANKL;Receptor activator of nuclear factor kappa B ligand;Receptor activator of nuclear factor kappa-B ligand;sOdf;TNF related activation induced cytokine;TNF-related activation-induced cytokine;TNF11_HUMAN;TNFSF 11;Tnfsf11;TRANCE;Tumor necrosis factor (ligand) superfamily member 11;Tumor necrosis factor ligand superfamily member 11;Tumor necrosis factor ligand superfamily member 11，soluble form |
| 英文名称 |
Recombinant human TNFSF11 protein |
| 全名 |
tumor necrosis factor (ligand) superfamily，member 11 |
| 中文名称 |
肿瘤坏死因子-α(配体)超家族成员11 |
| 外观(性状) |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
| 纯度 |
≥85% by SDS-PAGE. |
| 储存条件 |
Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
| 运输条件 |
冷藏运输 |
| 浓度 |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
O14788 |
| Gene ID |
8600 |
| 交叉反应 |
Human Mouse Rat |
| 分子量 |
28kDa |
| 区间范围 |
75-317aa |
| 背景说明 |
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
| 应用 |
Immunology research |
| 来源 |
E.coli |
| 纯化方法 |
NI-NTA affinity purification |
| 溶剂 |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 内毒素 |
Not measured |
| 生物活性 |
NO |
| 标签信息 |
With a 6×His tag at the N/C-terminus. |
| 规格 |
10ug 50ug 100ug 1mg |
| 研究领域 |
炎症与自身免疫疾病 |
| 单位 |
支 |
| 属性分类 |
重组抗原 |
| Y-研究领域 |
炎症与自身免疫疾病 |
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