基因名 |
TICAM2 |
别名 |
Putative NF-kappa-B-activating protein 502;TCAM2_HUMAN;TICAM-2;TICAM2;TIR containing adapter molecule 2;TIR domain containing adaptor protein;TIR domain-containing adapter molecule 2;TIRAP 3;TIRAP3;TIRAP3a short form;TIRP;Toll-like receptor adaptor protein 3;Toll/interleukin-1 receptor domain-containing protein;TRAM;TRIF-related adapter molecule |
英文名称 |
Recombinant human TICAM2 protein |
全名 |
toll-like receptor adaptor molecule 2 |
中文名称 |
Toll样蛋白受体衔接分子2 |
外观(性状) |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.) |
纯度 |
≥85% by SDS-PAGE. |
储存条件 |
Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year. |
运输条件 |
冷藏运输 |
浓度 |
1mg/ml by SDS-PAGE. |
Swiss Prot |
Q86XR7 |
Gene ID |
353376/100302736 |
交叉反应 |
Human Mouse (Bovine) |
分子量 |
27kDa |
区间范围 |
1-235aa |
背景说明 |
Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441).In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819).Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567).Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606). |
应用 |
Immunology research |
来源 |
E.coli |
纯化方法 |
NI-NTA affinity purification |
溶剂 |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
内毒素 |
Not measured |
生物活性 |
NO |
标签信息 |
With a 6×His tag at the N/C-terminus. |
规格 |
10ug 50ug 100ug 1mg |
研究领域 |
炎症与自身免疫疾病 |
单位 |
支 |
属性分类 |
重组抗原 |
Y-研究领域 |
炎症与自身免疫疾病 |