Recombinant human TNFAIP3 protein_索莱宝|主营生物科研试剂&抗体|蛋白|多肽|试剂盒|专业定制化服务平台-Solarbio【网上商城】

基因名	TNFAIP3
别名	A20;AISBL;OTUD7C;TNFA1P2；AISBL;MGC104522;MGC138687;MGC138688;OTU domain containing protein 7C;OTU domain-containing protein 7C;OTUD7C;Putative DNA binding protein A20;Putative DNA-binding protein A20;TNAP3_HUMAN;TNF alpha-induced protein 3;TNFA1P2;TNFAIP 3;TNFAIP3 (A20);TNFAIP3;Tumor necrosis factor alpha induced protein 3;Tumor necrosis factor alpha-induced protein 3;Tumor necrosis factor induced protein 3;Tumor necrosis factor inducible protein A20;tumor necrosis factor，alpha-induced protein 3;Zinc finger protein A20;Tumor necrosis factor alpha-induced protein 3
英文名称	Recombinant human TNFAIP3 protein
全名	tumor necrosis factor，alpha-induced protein 3
中文名称	肿瘤坏死因子-α诱导蛋白3
外观(性状)	Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度	≥85% by SDS-PAGE.
储存条件	Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件	The product is shipped at 2-8°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度	1mg/ml by SDS-PAGE.
Swiss Prot	P21580
Gene ID	7128
交叉反应	Human Mouse (Monkey)
分子量	29kDa
区间范围	1-249aa
背景说明	Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
应用	Immunology research
来源	E.coli
纯化方法	NI-NTA affinity purification
溶剂	Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素	Not measured
生物活性	NO
标签信息	With a 6×His tag at the N/C-terminus.
规格	10ug 50ug 100ug 1mg
研究领域	炎症与自身免疫疾病
单位	支
属性分类	重组抗原
Y-研究领域	炎症与自身免疫疾病